公开(公告)号：US20170253898A1

公开(公告)日：2017-09-07

申请号：US15517761

申请日：2015-11-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Christina D. SMOLKE ,  Yanran LI

IPC分类号： C12P17/18 ,  C12N1/14 ,  C12P13/16 ,  C07D515/22 ,  C07D273/01 ,  C07D515/14 ,  C07D515/02 ,  C12N9/10 ,  C12N1/02

CPC分类号： C12P17/188 ,  C07D273/01 ,  C07D515/02 ,  C07D515/14 ,  C07D515/22 ,  C12N1/02 ,  C12N1/14 ,  C12N9/1003 ,  C12N2330/50 ,  C12P13/16

摘要： Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided.