公开(公告)号：US20170253898A1

公开(公告)日：2017-09-07

申请号：US15517761

申请日：2015-11-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Christina D. SMOLKE ,  Yanran LI

IPC分类号： C12P17/18 ,  C12N1/14 ,  C12P13/16 ,  C07D515/22 ,  C07D273/01 ,  C07D515/14 ,  C07D515/02 ,  C12N9/10 ,  C12N1/02

CPC分类号： C12P17/188 ,  C07D273/01 ,  C07D515/02 ,  C07D515/14 ,  C07D515/22 ,  C12N1/02 ,  C12N1/14 ,  C12N9/1003 ,  C12N2330/50 ,  C12P13/16

摘要： Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided.

公开(公告)号：US20180127791A1

公开(公告)日：2018-05-10

申请号：US15565451

申请日：2016-04-04

申请人： Steffen SCHAFFER ,  Katrin GRAMMANN ,  Liv REINECKE

发明人： Steffen SCHAFFER ,  Katrin GRAMMANN ,  Liv REINECKE

IPC分类号： C12P13/16 ,  C12P13/14 ,  C12N9/10 ,  C12N9/00 ,  C12N9/16

CPC分类号： C12P13/16 ,  C12N9/1029 ,  C12N9/16 ,  C12N9/93 ,  C12P13/04 ,  C12P13/14 ,  C12Y203/01013 ,  C12Y301/02 ,  C12Y602/01003

摘要： The present invention relates to a microbial cell for producing at least one acyl amino acid, wherein the cell is genetically modified to comprise; a first genetic mutation that enables the cell to produce at least one acyl amino acid and; a second genetic mutation that enables the cell to decrease glutamate breakdown relative to the wild type cell.

公开(公告)号：US3164531A

公开(公告)日：1965-01-05

申请号：US23027562

申请日：1962-10-12

申请人： AJINOMOTO KK ,  SANRAKU OCEAN CO INC

发明人： HIROSHI OKADA ,  KOICHI TAKINAMI ,  HARUO TSURI ,  ISAMU SHIIO ,  TOSHINAO TSUNODA

IPC分类号： C12P13/14 ,  C12P13/16

CPC分类号： C12P13/14 ,  C12P13/16 ,  Y10S435/84