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公开(公告)号：US20240277794A1
公开(公告)日：2024-08-22
申请号：US18639303
申请日：2024-04-18
IPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/47 , C12N15/86
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/4702 , C12N15/86
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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2.发明授权公开(公告)号：US08357363B2
公开(公告)日：2013-01-22
申请号：US10481112
申请日：2002-06-12
申请人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
发明人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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公开(公告)号：US20230338445A1
公开(公告)日：2023-10-26
申请号：US18322961
申请日：2023-05-24
IPC分类号： A61K35/768 , C07K14/47 , C07K14/065 , C12N15/86 , A61K45/06 , A61P35/00
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/4702 , C12N15/86
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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4.发明申请RECOMBINANT PROTEINS OF PARAPOXVIRUS OVIS AND PHARMACEUTICAL COMPOSITIONS THEREFROM 有权PAR US ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM公开(公告)号：US20140377297A1
公开(公告)日：2014-12-25
申请号：US14480463
申请日：2014-09-08
发明人： Olaf WEBER , Sonja Maria TENNAGELS , Angela SIEGLING , Tobias SCHLAPP , Andrew Allan MERCER , Stephen Bruce FLEMING , Hans-Dieter VOLK
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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公开(公告)号：US11963990B2
公开(公告)日：2024-04-23
申请号：US18322961
申请日：2023-05-24
IPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/47 , C12N15/86
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/4702 , C12N15/86
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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公开(公告)号：US20230263846A1
公开(公告)日：2023-08-24
申请号：US18080253
申请日：2022-12-13
IPC分类号： A61K35/768 , C12N15/86 , C07K14/47 , C07K14/065 , A61K45/06 , A61P35/00
CPC分类号： A61K35/768 , C12N15/86 , C07K14/4702 , C07K14/065 , A61K45/06 , A61P35/00
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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公开(公告)号：US09714272B2
公开(公告)日：2017-07-25
申请号：US14480463
申请日：2014-09-08
发明人： Olaf Weber , Sonja Maria Tennagels , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： C07K14/065 , C12N15/86 , C07K14/005 , C12N7/00 , A61K38/00 , A61K48/00 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
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公开(公告)号：US20240277793A1
公开(公告)日：2024-08-22
申请号：US18606128
申请日：2024-03-15
IPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/47 , C12N15/86
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/4702 , C12N15/86
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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公开(公告)号：US12016893B2
公开(公告)日：2024-06-25
申请号：US18080253
申请日：2022-12-13
IPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/47 , C12N15/86
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C07K14/065 , C07K14/4702 , C12N15/86
摘要： The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.
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10.发明授权Recombinant proteins of Parapoxvirus ovis and pharmaceutical compositions therefrom 有权Parapoxvirus ovis的重组蛋白及其药物组合物公开(公告)号：US08852577B2
公开(公告)日：2014-10-07
申请号：US13717640
申请日：2012-12-17
发明人： Olaf Weber , Sonja Maria Tennagels , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , C07K14/065 , C12N15/86 , C07K14/005 , A61K39/00 , A61K48/00 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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