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1.发明授权公开(公告)号：US08357363B2
公开(公告)日：2013-01-22
申请号：US10481112
申请日：2002-06-12
申请人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
发明人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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公开(公告)号：US20110287051A1
公开(公告)日：2011-11-24
申请号：US13111020
申请日：2011-05-19
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5256 , A61K2039/541 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/24243 , C12N2760/20122 , C12N2760/20134
摘要： The present invention relates to recombinant parapoxviruses which carry in their genomes comprising heterologous DNA derived from a rabies virus, to the preparation of such constructs, and to their use in immunogenic compositions and vaccines. It further relates to the use of recombinant parapoxviruses for diagnostics.
摘要翻译： 本发明涉及携带其包含来自狂犬病病毒的异源DNA的基因组的重组副代谢病毒，以及其在免疫原性组合物和疫苗中的用途。 它还涉及使用重组副抗病毒用于诊断。
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公开(公告)号：US09714272B2
公开(公告)日：2017-07-25
申请号：US14480463
申请日：2014-09-08
发明人： Olaf Weber , Sonja Maria Tennagels , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： C07K14/065 , C12N15/86 , C07K14/005 , C12N7/00 , A61K38/00 , A61K48/00 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
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4.发明授权Parapoxviruses containing foreign DNA, their production and their use in vaccines 有权含有外源DNA的旁寄生虫病毒，其生产及其在疫苗中的应用公开(公告)号：US06365393B1
公开(公告)日：2002-04-02
申请号：US09125642
申请日：1998-08-20
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/24222 , C12N2710/24243
摘要： The present invention relates to recombinantly prepared parapoxviruses which carry, in their genomes, deletions or insertions in the form of foreign hereditary information and contain hereditary information, to the preparation of such constructs and to their use in vaccines.
摘要翻译： 本发明涉及重组制备的副代谢病毒，其在其基因组中携带外来遗传信息形式的缺失或插入并含有遗传信息，以及其在疫苗中的应用。
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公开(公告)号：US20180148739A1
公开(公告)日：2018-05-31
申请号：US15875389
申请日：2018-01-19
发明人： Hans-Joachim Rziha , Ralf Amann
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/5154 , C12N2015/8572 , C12N2015/8581 , C12N2710/24031 , C12N2710/24041 , C12N2710/24222 , C12N2710/24243 , C12N2840/10
摘要： A nucleic acid molecule can code for an Orf virus vector promoter. A recombinant Orf virus vector can be included in a cell. The nucleic acid molecule, the vector and/or the cell can be included in a composition. The recombinant Orf virus vector can be used for the production of a foreign gene.
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6.发明申请RECOMBINANT PROTEINS OF PARAPOXVIRUS OVIS AND PHARMACEUTICAL COMPOSITIONS THEREFROM 有权PAR US ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM公开(公告)号：US20140377297A1
公开(公告)日：2014-12-25
申请号：US14480463
申请日：2014-09-08
发明人： Olaf WEBER , Sonja Maria TENNAGELS , Angela SIEGLING , Tobias SCHLAPP , Andrew Allan MERCER , Stephen Bruce FLEMING , Hans-Dieter VOLK
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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公开(公告)号：US20120020995A1
公开(公告)日：2012-01-26
申请号：US13185561
申请日：2011-07-19
IPC分类号： A61K39/275 , A61P31/14 , A61P37/04 , C12N7/01 , C12Q1/70
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2710/24243 , C12N2760/18434
摘要： The present invention relates to recombinant parapoxviruses comprising heterologous DNA derived from a canine distemper virus, to the preparation of such constructs, and to their use in immunogenic compositions and vaccines. It further relates to the use of recombinant parapoxviruses for diagnostics.
摘要翻译： 本发明涉及包含衍生自犬瘟热病毒的异源DNA，这种构建体的制备以及它们在免疫原性组合物和疫苗中的用途的重组副抗原病毒。 它还涉及使用重组副抗病毒用于诊断。
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公开(公告)号：US20240043870A1
公开(公告)日：2024-02-08
申请号：US18258508
申请日：2021-12-14
发明人： Ralf AMANN , Ferdinand SALOMON
IPC分类号： C12N15/86 , A61K39/275 , A61P31/20 , A61K39/215
CPC分类号： C12N15/86 , A61K39/275 , A61P31/20 , A61K39/215 , C12N2710/24243 , C12N2710/24271 , C12N2760/16122 , C12N2760/20122 , C12N2770/20022 , A61K2039/5256
摘要： The present invention relates to a modified Parapoxvirus, preferably a Parapoxvirus vector, having an increased munogenicity, a biological cell containing said modified Parapoxvirus, a pharmaceutical composition, preferably a vaccine, containing said modified Parapoxvirus vector and/or said cell, and a new use of said modified Parapoxvirus.
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9.发明申请PARAPOXVIRUS EXPRESSING THE VP60 MAJOR CAPSID PROTEIN OF THE RABBIT HAEMORRHAGIC DISEASE VIRUS 审中-公开表达VP60主要CAPSID蛋白的RAPBIO易感性病毒病毒公开(公告)号：US20130177582A1
公开(公告)日：2013-07-11
申请号：US13643547
申请日：2011-04-29
申请人： Hanns-Joachim Rziha
发明人： Hanns-Joachim Rziha
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C07K14/08 , C12N7/00 , C12N15/86 , C12N2710/24243 , C12N2770/16022 , C12N2770/16034
摘要： The invention describes a therapeutic agent capable of treating and/or preventing rabbit haemorrhagic disease virus infection in rabbits, namely a recombinant parapoxvirus, characterized in that the VP60 major capsid protein from the rabbit haemorrhagic disease virus (RHDV) is expressed from a foreign nucleic acid.
摘要翻译： 本发明描述了能够治疗和/或预防兔出血性病毒感染的治疗剂，即重组副抗病毒，其特征在于来自兔出血性疾病病毒（RHDV）的VP60主要衣壳蛋白来自外源核酸 。
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10.发明申请Organ, tissue and cell-specific immuno-therapeutic for chronic viral infections and inflammatory, degenerative and proliferative diseases, in particular of the liver, and for cancer, based on a recombinant parapox virus 审中-公开用于慢性病毒感染和炎性，退行性和增殖性疾病，特别是肝脏和癌症的器官，组织和细胞特异性免疫治疗，基于重组旁分泌病毒公开(公告)号：US20060008471A1
公开(公告)日：2006-01-12
申请号：US11225508
申请日：2005-09-13
申请人： Olaf Weber , Angela Siegling , Tobias Schlapp
发明人： Olaf Weber , Angela Siegling , Tobias Schlapp
IPC分类号： A61K39/12
CPC分类号： C12N15/86 , C12N15/87 , C12N2710/24243
摘要： The present invention relates to the preparation and use of organ-specific, tissue-specific and/or cell-specific recombinant parapoxvirus ovis as a pathogen-specific and organ-specific, targeted immunotherapeutic agent for chronic viral infections and inflammatory, degenerative and proliferative diseases, in particular of the liver, and cancer.
摘要翻译： 本发明涉及器官特异性，组织特异性和/或细胞特异性重组副痘病毒ovis作为慢性病毒感染和炎性，退行性和增殖性疾病的病原体特异性和器官特异性靶向免疫治疗剂的制备和用途 ，特别是肝脏和癌症。
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