公开(公告)号：US06303106B1

公开(公告)日：2001-10-16

申请号：US09077912

申请日：1998-09-25

申请人： Nigel E. Banister ,  Peter S. J. Cheetham

发明人： Nigel E. Banister ,  Peter S. J. Cheetham

IPC分类号： A61K7135

CPC分类号： A61K8/66 ,  A61K8/72 ,  A61Q5/10 ,  A61Q19/04 ,  C09B69/104 ,  C12P17/00 ,  Y10S514/944

摘要： A method of producing a melanin comprises oxidizing a phenolic compound at one or more hydroxyl groups thereof, wherein the phenolic compound is selected from 5-hydroxyindole and derivatives thereof and compounds of formula (1) and the oxidation is provided by biotransformation in the presence of an oxidoreductase enzyme, the compound of formula (1), wherein R1 is H or OH; R2 is H, OH orOCH3; R3 is H or OH at least one of R1 and R3 being OH; R4 is selected from H , R, —COOX and R7—COOX, wherein R is an optionally substituted saturated or unsaturated alkyl group having from 1 to 12 carbon atoms, R7 is an optionally substituted saturated or unsaturated alkylene group having from 1 to 12 carbon atoms and X is selected from H and aliphatic and aromatic ester forming groups; and R5 and R6 is each independently selected from H, OH, NH2, OCH3, CH3, SH, NHCO2, NHCH3, COOH and saturated or unsaturated alkyl groups having up to 8 carbon atoms.

摘要翻译： 一种生产黑色素的方法包括在其一个或多个羟基处氧化酚类化合物，其中酚类化合物选自5-羟基吲哚及其衍生物和式（1）化合物，氧化通过生物转化在存在 氧化还原酶，式（1）化合物，其中R 1是H或OH; R2是H，OH或OCH3; R 3为H或OH，R 1和R 3中的至少一个为OH; R4选自H，R，-COOX和R7-COOX，其中R是具有1至12个碳原子的任选取代的饱和或不饱和烷基，R7是具有1至12个碳原子的任选取代的饱和或不饱和亚烷基 原子，X选自H和脂族和芳族酯形成基团; 并且R 5和R 6各自独立地选自H，OH，NH 2，OCH 3，CH 3，SH，NHCO 2，NHCH 3，COOH和具有至多8个碳原子的饱和或不饱和烷基。

公开(公告)号：US20100028474A1

公开(公告)日：2010-02-04

申请号：US12510395

申请日：2009-07-28

申请人： Thomas Eidenberger

发明人： Thomas Eidenberger

IPC分类号： A61K36/185 ,  C09K15/26 ,  C09K15/34 ,  C07D307/02 ,  C07K14/47

CPC分类号： A61K36/185 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  C09B61/00 ,  C09B69/104 ,  A23V2200/326 ,  A23V2250/21 ,  A23V2250/708

摘要： The invention describes reduced sesame seed derived pigments and methods to prepare such pigments.

摘要翻译： 本发明描述了减少的芝麻籽衍生的颜料和制备这种颜料的方法。

公开(公告)号：US5643554A

公开(公告)日：1997-07-01

申请号：US54271

申请日：1993-04-30

申请人： I. Avavindakshan Menon ,  Herbert F. Haberman

发明人： I. Avavindakshan Menon ,  Herbert F. Haberman

IPC分类号： A61K8/35 ,  A61K8/44 ,  A61K8/72 ,  A61Q17/04 ,  C09B69/10 ,  A61K7/42 ,  A61K31/20

CPC分类号： A61K8/35 ,  A61K8/445 ,  A61K8/72 ,  A61Q17/04 ,  C09B69/104 ,  A61K2800/57

摘要： A novel lipomelanin sunscreen complex includes melanin linked to a lipid to form a lipomelanin. One or more ultra-violet-light absorbing compounds can be added to form a lipomelanin sunscreen complex. A method for making the complex includes the oxidization of DOPA in the presence of a lipid and one or more ultra-violet absorbing compounds to form a mixture and precipitating the complex from the mixture by the addition of acid. The lipomelanin sunscreen complex provides protection against harmful ultra-violet radiation. The level of UV protection may be varied according to the presence and properties of the ultra-violet absorbing compounds in the complex.

摘要翻译： 一种新型脂质珠蛋白防晒复合物包括与脂质连接以形成脂质珠蛋白的黑色素。 可以加入一种或多种紫外光吸收化合物以形成脂质乳胶素防晒复合物。 制备复合物的方法包括在脂质和一种或多种紫外吸收化合物存在下DOPA的氧化以形成混合物并通过加入酸从混合物中沉淀出复合物。 脂质乳胶防晒复合物提供防止有害紫外线辐射的保护。 紫外线防护的水平可以根据复合物中紫外吸收化合物的存在和性质而变化。

公开(公告)号：US5244497A

公开(公告)日：1993-09-14

申请号：US649865

申请日：1991-02-05

申请人： Alex Junino ,  Herve Andrean ,  Remi Tuloup ,  Irwing J. Higgins

发明人： Alex Junino ,  Herve Andrean ,  Remi Tuloup ,  Irwing J. Higgins

IPC分类号： C12P17/12 ,  A61K8/49 ,  A61K8/72 ,  A61Q5/10 ,  C09B69/10 ,  C12P17/00 ,  C12P17/10

CPC分类号： A61K8/72 ,  A61K8/492 ,  A61Q5/10 ,  C09B69/104 ,  C12P17/00

摘要： The invention relates to a process for the preparation of a melanic pigment, comprising the polymerisation of a compound corresponding to the formula: ##STR1## in which: R denotes a hydrogen atom, an alkyl, alkoxy, hydroxyalkyl, SiR.sub.4 R.sub.5 R.sub.6 or aminoalkyl radical, or an aryl radical which is unsubstituted or substituted by OH, NH.sub.2, alkyl, alkoxy or NO.sub.2 ;R.sub.1 and R.sub.2 denote alkyl groups or together form a methylene or ethylene group which is optionally substituted by one or more alkyl groups, and R.sub.2 denotes hydrogen or COOH, in the presence of an oxidizing medium and of an enzyme with (per)oxidizing activity or of a compound which has a similar activity, and to powders which make use of them and to their cosmetic use.

摘要翻译： 本发明涉及一种制备黑色素的方法，包括对应于下式的化合物的聚合：其中：R表示氢原子，烷基，烷氧基，羟基烷基，SiR 4 R 5 R 6或氨基烷基 或未取代或被OH，NH 2，烷基，烷氧基或NO 2取代的芳基; R1和R2表示烷基或一起形成任选被一个或多个烷基取代的亚甲基或亚乙基，R 2表示氢或COOH，在氧化介质和具有（以下）氧化活性的酶或 具有相似活性的化合物和使用它们的粉末及其化妆品用途的粉末。

公开(公告)号：US08816040B2

公开(公告)日：2014-08-26

申请号：US13461933

申请日：2012-05-02

申请人： Takaki Kanbara ,  Junpei Kuwabara ,  Hikaru Yamada ,  Nobutaka Fujimoto

发明人： Takaki Kanbara ,  Junpei Kuwabara ,  Hikaru Yamada ,  Nobutaka Fujimoto

IPC分类号： C08G73/06

CPC分类号： C08G73/02 ,  C09B69/101 ,  C09B69/104 ,  C09B69/109

摘要： A polymer dye has repeating units of formula (I): Each of R1, R2, and R3 is independently a monocyclic carbocyclic group, a condensed polycyclic carbocyclic group, a monocyclic heterocyclic group, or a condensed polycyclic heterocyclic group. In any case, each of R1, R2, and R3 independently may have a substituent. R1 is a divalent group, and R2 and R3 are monovalent groups. D is an organic dye group and n is an integer of from 0 to 10. The polymer dye has a number-average molecular weight of from 500 to 500,000. The dye can be a component in a film. The dye can also be included in various industrial materials in automobiles; communication instruments, such as mobile phones, PDA, remote controllers, mobile information terminals, electronic dictionaries, and electronic organizers; home electric appliances; construction parts; and the like.

摘要翻译： 聚合物染料具有式（I）的重复单元：R 1，R 2和R 3各自独立地为单环碳环基，稠合多环碳环基，单环杂环基或缩合多环杂环基。 在任何情况下，R 1，R 2和R 3各自独立地可以具有取代基。 R1是二价基团，R2和R3是一价基团。 D为有机染料基团，n为0〜10的整数。聚合物染料的数均分子量为500〜500,000。 染料可以是膜中的一种成分。 染料也可以包含在汽车的各种工业材料中; 通讯仪器，如手机，PDA，遥控器，移动信息终端，电子词典和电子组织者; 家用电器; 施工部件; 等等。

公开(公告)号：US20120329978A1

公开(公告)日：2012-12-27

申请号：US13461933

申请日：2012-05-02

申请人： Takaki Kanbara ,  Junpei Kuwabara ,  Hikaru Yamada ,  Nobutaka Fujimoto

发明人： Takaki Kanbara ,  Junpei Kuwabara ,  Hikaru Yamada ,  Nobutaka Fujimoto

IPC分类号： C08G73/06

CPC分类号： C08G73/02 ,  C09B69/101 ,  C09B69/104 ,  C09B69/109

摘要： A polymer dye has repeating units of formula (I): Each of R1, R2, and R3 is independently a monocyclic carbocyclic group, a condensed polycyclic carbocyclic group, a monocyclic heterocyclic group, or a condensed polycyclic heterocyclic group. In any case, each of R1, R2, and R3 independently may have a substituent. R1 is a divalent group, and R2 and R3 are monovalent groups. D is an organic dye group and n is an integer of from 0 to 10. The polymer dye has a number-average molecular weight of from 500 to 500,000. The dye can be a component in a film. The dye can also be included in various industrial materials in automobiles; communication instruments, such as mobile phones, PDA, remote controllers, mobile information terminals, electronic dictionaries, and electronic organizers; home electric appliances; construction parts; and the like.

摘要翻译： 聚合物染料具有式（I）的重复单元：R 1，R 2和R 3各自独立地为单环碳环基，稠合多环碳环基，单环杂环基或稠合多环杂环基。 在任何情况下，R 1，R 2和R 3各自独立地可以具有取代基。 R1是二价基团，R2和R3是一价基团。 D为有机染料基团，n为0〜10的整数。聚合物染料的数均分子量为500〜500,000。 染料可以是膜中的一种成分。 染料也可以包含在汽车的各种工业材料中; 通讯仪器，如手机，PDA，遥控器，移动信息终端，电子词典和电子组织者; 家用电器; 施工部件; 等等。

公开(公告)号：US20090317616A1

公开(公告)日：2009-12-24

申请号：US11995621

申请日：2006-07-14

申请人： Ryozo Kawai ,  Yoshiyuki Aoki ,  Eiko Aoki ,  Kyohei Takakuwa ,  Masahiko Namiki

发明人： Ryozo Kawai ,  Yoshiyuki Aoki ,  Eiko Aoki ,  Kyohei Takakuwa ,  Masahiko Namiki

IPC分类号： C08L29/04 ,  C04B14/00

CPC分类号： C09B59/00 ,  C09B67/0097 ,  C09B69/104 ,  G02B5/208 ,  G02B5/3033

摘要： The present invention provides a melanin that is excellent in coloring a functional film, and in reproducibility and stability during storage, and a method for its production. Also, the invention provides a functional film containing a melanin and its method for production. Specifically, it provides a functional film containing a melanin of which the alteration is improved and which is excellent in the property for protecting eyes from ultraviolet rays, and in its method for production.The method for producing a melanin of the present invention, comprises, at least, under controlled conditions, a step for an oxidative reaction wherein a melanin precursor is continuously oxidized while the mole ratio of the melanin precursor relative to the oxidative agent is maintained at a constant ratio, and a step for precipitation wherein a melanin is precipitated by acidifying a reaction solution after the step for an oxidative reaction.

摘要翻译： 本发明提供了对功能性膜着色，保存时的再现性和稳定性优异的黑色素及其制造方法。 另外，本发明提供含有黑色素的功能性膜及其制造方法。 具体地说，提供了含有黑色素的功能性膜，其变化得到改善，并且在保护眼睛免受紫外线的性质方面优异，并且在其生产方法中。 本发明的黑色素的制备方法至少在受控条件下，包括氧化反应的步骤，其中黑色素前体被连续氧化，而黑色素前体相对于氧化剂的摩尔比保持在 恒定比例和沉淀步骤，其中通过在氧化反应步骤之后使反应溶液酸化而使黑色素沉淀。

公开(公告)号：US5583234A

公开(公告)日：1996-12-10

申请号：US119072

申请日：1993-12-29

申请人： Alain Lagrange ,  Herv e Andrean ,  Alex Junino

发明人： Alain Lagrange ,  Herv e Andrean ,  Alex Junino

IPC分类号： A61K8/00 ,  A61K8/04 ,  A61K8/49 ,  A61K8/89 ,  A61K8/891 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q3/00 ,  A61Q3/02 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q17/04 ,  C07D209/04 ,  C07D209/08 ,  C07D209/10 ,  C08G61/12 ,  C08G73/06 ,  C08K5/3417 ,  C08L101/00 ,  C09B69/10 ,  A61K7/13

CPC分类号： A61Q17/04 ,  A61K8/492 ,  A61Q1/02 ,  A61Q5/10 ,  C08G61/124 ,  C09B69/104

摘要： An indoline product obtained by oxidizing at least one compound of formula (I), ##STR1## wherein R.sub.1 and R.sub.3 independently represent a hydrogen atom or a C.sub.1-4 alkyl grouping; R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkyl grouping, a carboxyl grouping or C.sub.1-4 alkoxycarbonyl; R.sub.4 is a hydrogen atom, a C.sub.1-4 alkyl grouping, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-10 amino or alkylamino, or halogen; R.sub.5 is a hydrogen atom, a hydroxyl grouping, C.sub.1-4 alkoxy or amino; with the proviso that at least one of the radicals R.sub.4 or R.sub.5 is a hydroxyl, alkoxy or amino grouping, and that when R.sub.5 is an amino grouping, R.sub.4 is not an alkylamino radical; R.sub.4 and R.sub.5 may also form a C.sub.1-2 alkylenedioxy ring and are in positions 5 and 6; and corresponding salts thereof. Said product may be used in cosmetics as make-up for the hair, eyebrows, eyelashes, nails, etc., and/or skin.

摘要翻译： PCT No.PCT / FR93 / 00030 Sec。 371日期1993年12月29日第 102（e）日期1993年12月29日PCT 1993年1月13日PCT PCT。 第WO93 / 13744号公报 日期：1993年7月22日通过氧化至少一种式（I）化合物，其中R 1和R 3独立地表示氢原子或C 1-4烷基; R2表示氢原子，C1-4烷基，羧基或C1-4烷氧基羰基; R4是氢原子，C1-4烷基，羟基，C1-4烷氧基，C1-10氨基或烷基氨基或卤素; R5是氢原子，羟基，C1-4烷氧基或氨基; 条件是基团R 4或R 5中的至少一个是羟基，烷氧基或氨基，并且当R 5是氨基时，R 4不是烷基氨基; R4和R5也可以形成C1-2亚烷基二氧基环，位于5和6位; 及其相应的盐。 所述产品可用于化妆品中作为头发，眉毛，睫毛，指甲等的化妆和/或皮肤。

公开(公告)号：US5571700A

公开(公告)日：1996-11-05

申请号：US256576

申请日：1994-07-18

申请人： Alex Junino ,  Pascal Hilaire ,  Richard Martin

发明人： Alex Junino ,  Pascal Hilaire ,  Richard Martin

IPC分类号： C12P17/18 ,  A61K8/00 ,  A61K8/18 ,  A61K8/49 ,  A61K8/72 ,  A61K8/96 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q5/06 ,  A61Q5/10 ,  A61Q17/04 ,  C09B59/00 ,  C09B69/10 ,  C12P1/00 ,  C12P17/00 ,  C12P17/10 ,  C12P21/00 ,  A61K7/00

CPC分类号： C12P17/00 ,  A61K8/492 ,  A61K8/72 ,  A61Q1/10 ,  A61Q5/10 ,  C09B69/104 ,  A61K2800/43

摘要： The present invention relates to a method for the preparation of a melanic pigment by enzymatic bioconversion, implementing a melanin precursor substrate and plant cells, characterized in that: (a) poppy (Papaver somniferum) plant cells previously cultivated are separated from their culture medium and subcultured in a culture medium with a concentration from 10 to 100 g/l; (b) the cells are ground at least partially, before or at the end of the latency time, (c) the at least partially ground cells are placed in a bioconversion medium in the presence with a melanin precursor substrate selected amoung indol, indolin, dihydroxyphenylalanin, tyramin and tyrosin; (d) the precipitated melanic pigment is collected. The invention also relates to the utilization of such resulting pigments for the preparation of cosmetic compositions.

摘要翻译： PCT No.PCT / FR93 / 01138 Sec。 371日期：1994年7月18日 102（e）1994年7月18日PCT 1993年11月19日PCT公布。 公开号WO94 / 12653 日期：1994年6月9日本发明涉及一种通过酶促生物转化制备黑色素的方法，其实施黑色素前体底物和植物细胞，其特征在于：（a）先前培养的罂粟（Papaver somniferum）植物细胞被分离 从其培养基中传代培养在浓度为10至100g / l的培养基中; （b）在等待时间之前或结束时，至少部分地研磨细胞，（c）在选择中性吲哚，二氢吲哚，二氢吲哚等的黑色素前体底物存在下将至少部分研磨的细胞置于生物转化培养基中， 二羟基苯丙氨酸，替米沙明和酪氨酸; （d）收集沉淀的黑色素。 本发明还涉及这种所得颜料用于制备化妆品组合物的用途。

公开(公告)号：US20190233651A1

公开(公告)日：2019-08-01

申请号：US16311568

申请日：2017-06-22

申请人： FUJIFILM Wako Pure Chemical Corporation

发明人： Katsufumi SUZUKI ,  Tetsuji MURASE ,  Shigeaki IMAZEKI

IPC分类号： C09B69/10 ,  C08F230/08 ,  G02B5/22 ,  G02F1/1335

CPC分类号： C09B69/104 ,  C07F7/10 ,  C08F30/08 ,  C08F230/08 ,  C09B11/28 ,  C09B69/101 ,  C09K3/00 ,  G02B5/20 ,  G02B5/223 ,  G02F1/133514 ,  G02F2202/022

摘要： Quenchers of the related art do not have a quenching ability high enough to sufficiently inhibit the emission of fluorescence from fluorescence compounds. Therefore, the present invention aims to provide a quencher which can sufficiently quench the fluorescence from fluorescent compounds including xanthene-based dyes. The present invention relates to a quencher formed of a compound represented by the following general formula (1), and the like. (In the formula, n1 pieces of R5 each independently represent a group having a polymerizable unsaturated group, an amino group having a substituent, or the like, R6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like, An− represents an anion, Ar1 represents a specific ring structure, * and ** each represent a position of bonding to the specific ring structure, Ar2 represents a benzene ring or the like, in a case where Ar2 is the benzene ring, n1 represents an integer of 0 to 4, and R32 and R33 each independently represent an alkyl group or an aryl group.)