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    Heparin prodrugs and drug delivery stents formed therefrom
    1.
    发明授权
    Heparin prodrugs and drug delivery stents formed therefrom 失效
    肝素前药和由其形成的药物递送支架

    公开(公告)号：US07563780B1

    公开(公告)日：2009-07-21

    申请号：US10871658

    申请日：2004-06-18

    申请人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    发明人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    IPC分类号： C08B37/10 ,  A61K31/727 ,  A61P7/02

    CPC分类号： A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

    摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Heparin prodrugs and drug delivery stents formed therefrom
    2.
    发明授权
    Heparin prodrugs and drug delivery stents formed therefrom 有权
    肝素前药和由其形成的药物递送支架

    公开(公告)号：US07396541B2

    公开(公告)日：2008-07-08

    申请号：US11228420

    申请日：2005-09-15

    申请人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    发明人： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    IPC分类号： A61F2/00

    CPC分类号： A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

    摘要： A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Non-thrombogenic coating composition and methods for using same
    3.
    发明申请
    Non-thrombogenic coating composition and methods for using same 有权
    非血栓形成的涂层组合物及其使用方法

    公开(公告)号：US20020115836A1

    公开(公告)日：2002-08-22

    申请号：US10047118

    申请日：2002-01-14

    发明人： Ray Tsang ,  Shigemasa Osaki

    IPC分类号： A61K031/727 ,  C08B037/10

    CPC分类号： A61L33/0029 ,  A61L27/28 ,  A61L31/08 ,  A61L33/0011 ,  A61L33/08 ,  C08B37/0063 ,  C08B37/0075 ,  C08G77/60 ,  C09D105/08 ,  C09D105/10 ,  C08L83/00

    摘要： The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: 1 wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.

    摘要翻译： 本发明提供了用于接触血液的表面的抗血栓形成和细胞粘附涂层组合物。 该涂层包含1至30个式I的疏水性甲硅烷基部分的共价络合物：其中R1是C1-18烷基或C6-32芳基，每个R2独立地选自C1-18烷基和C6- 32芳基，R3是N或O，n是1至10的数，通过共价键直接与肝素分子结合，其中粘合分子与肝素分子直接结合。 在一个实施方案中，涂层包含苄基 - （1,2二甲基）二甲硅烷基肝素，其中粘合剂分子例如纤连蛋白与肝素结合。