公开(公告)号：US20070054398A1

公开(公告)日：2007-03-08

申请号：US10546286

申请日：2004-02-20

申请人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

发明人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

IPC分类号： C12N5/08

CPC分类号： C12N5/0672 ,  A61K35/12 ,  C12N5/0633 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/235 ,  C12N2501/335 ,  C12N2506/098

摘要： A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

摘要翻译： 公开了一种可以分化成包括人肝脏在内的多个人体器官的细胞的新型人类干细胞。 本发明人干细胞源自人唾液腺，其为CD49f阳性，可分化为（1）巢蛋白阳性和白蛋白阳性细胞，（2）胰岛素阳性细胞和 （3）体外培养胰高血糖素阳性细胞。

公开(公告)号：US07659121B2

公开(公告)日：2010-02-09

申请号：US11902018

申请日：2007-09-18

申请人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

发明人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

IPC分类号： C12N5/00 ,  C12N15/00

CPC分类号： C12N5/0672 ,  A61K35/12 ,  C12N5/0633 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/235 ,  C12N2501/335 ,  C12N2506/098

摘要： A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

摘要翻译： 公开了一种可以分化成包括人肝脏在内的多个人体器官的细胞的新型人类干细胞。 本发明人干细胞源自人唾液腺，其为CD49f阳性，可分化为（1）巢蛋白阳性和白蛋白阳性细胞，（2）胰岛素阳性细胞和 （3）体外培养胰高血糖素阳性细胞。

公开(公告)号：US20090068734A1

公开(公告)日：2009-03-12

申请号：US11902018

申请日：2007-09-18

申请人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

发明人： Fumio Endo ,  Kenji Okumura ,  Kimitoshi Nakamura

IPC分类号： C12N5/08

CPC分类号： C12N5/0672 ,  A61K35/12 ,  C12N5/0633 ,  C12N5/0676 ,  C12N5/0678 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/235 ,  C12N2501/335 ,  C12N2506/098

摘要： A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

摘要翻译： 公开了一种可以分化成包括人肝脏在内的多个人体器官的细胞的新型人类干细胞。 本发明人干细胞源自人唾液腺，其为CD49f阳性，可分化为（1）巢蛋白阳性和白蛋白阳性细胞，（2）胰岛素阳性细胞和 （3）体外培养胰高血糖素阳性细胞。