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8 条记录 (耗时 0.011 秒)

    RECOMBINANT VIRUS-LIKE PARTICLES ENCODED BY MULTI-GENE VECTOR
    5.
    发明申请
    RECOMBINANT VIRUS-LIKE PARTICLES ENCODED BY MULTI-GENE VECTOR 有权
    由多载体编码的重组病毒样颗粒

    公开(公告)号：US20150004690A1

    公开(公告)日：2015-01-01

    申请号：US14472911

    申请日：2014-08-29

    申请人： REDBIOTEC AG

    发明人： Corinne JOHN ,  Christian SCHAUB ,  Sabine WELLNITZ

    IPC分类号： C12N15/86 ,  C12N7/00

    CPC分类号： C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2710/16123 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2760/16023 ,  C12N2760/16123 ,  C12N2760/16134

    摘要： The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.

    摘要翻译： 本发明描述了用作疫苗，诊断工具和基于重组DNA和用于生产的细胞培养技术的研发工具的新型病毒样颗粒。 本发明的重组病毒样颗粒通过多肽链组装，其包含数个，特别是两个或多个不同的表位，其选自（a）来自相同病毒的不同病毒株和/或（b）不同血清型 相同病毒和/或（c）来自不同宿主特异性的不同病毒株。 然后将这些表位显示在颗粒表面上。

    Recombinant virus-like particles encoded by multi-gene vector
    6.
    发明授权
    Recombinant virus-like particles encoded by multi-gene vector 有权
    由多基因载体编码的重组病毒样颗粒

    公开(公告)号：US09309536B2

    公开(公告)日：2016-04-12

    申请号：US14472911

    申请日：2014-08-29

    申请人： Pfizer Inc.

    发明人： Corinne John ,  Christian Schaub ,  Sabine Wellnitz

    IPC分类号： C12N15/86 ,  C12N7/00 ,  A61K39/00

    CPC分类号： C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2710/16123 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2760/16023 ,  C12N2760/16123 ,  C12N2760/16134

    摘要： The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.

    摘要翻译： 本发明描述了用作疫苗，诊断工具和基于重组DNA和用于生产的细胞培养技术的研发工具的新型病毒样颗粒。 本发明的重组病毒样颗粒通过多肽链组装，其包含数个，特别是两个或多个不同的表位，其选自（a）来自相同病毒的不同病毒株和/或（b）不同血清型 相同病毒和/或（c）来自不同宿主特异性的不同病毒株。 然后将这些表位显示在颗粒表面上。

    RECOMBINANT PARTICLE BASED VACCINES AGAINST HUMAN CYTOMEGALOVIRUS INFECTION
    7.
    发明申请
    RECOMBINANT PARTICLE BASED VACCINES AGAINST HUMAN CYTOMEGALOVIRUS INFECTION 审中-公开
    基于重组颗粒的人类感染细胞因子疫苗

    公开(公告)号：US20150359879A1

    公开(公告)日：2015-12-17

    申请号：US14436943

    申请日：2013-10-30

    申请人： Redvax GmbH

    发明人： Sabine WELLNITZ ,  Corinne JOHN ,  Christian SCHAUB

    IPC分类号： A61K39/245 ,  C07K14/005 ,  C12N7/00

    CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/57 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16123 ,  C12N2710/16134

    摘要： The invention relates to gene and protein assemblies in the form of virus-like particles and protein complexes for use as prophylactic or therapeutic vaccines, and diagnostic and R&D tools for human cytomegalovirus (HCMV) and other herpes viruses. The virus-like particles comprise one or more capsid proteins from a herpes virus or a retrovirus, three or more CMV surface proteins and optionally tegument proteins. The assemblies are prepared using a technology combining recombinant DNA with disposable cell culture and purification techniques.

    摘要翻译： 本发明涉及用作预防或治疗疫苗的病毒样颗粒和蛋白质复合物形式的基因和蛋白质组装，以及用于人巨细胞病毒（HCMV）和其他疱疹病毒的诊断和研发工具。 病毒样颗粒包含一种或多种来自疱疹病毒或逆转录病毒的衣壳蛋白，三种或更多种CMV表面蛋白和任选的纤维蛋白。 使用结合重组DNA与一次性细胞培养和纯化技术的技术制备组装体。

    PRODUCTION OF A HCMV BASED VACCINE IN HUMAN AMNIOCYTE CELL LINES
    8.
    发明申请
    PRODUCTION OF A HCMV BASED VACCINE IN HUMAN AMNIOCYTE CELL LINES 审中-公开
    在人体细胞系中生产基于HCMV的疫苗

    公开(公告)号：US20150259387A1

    公开(公告)日：2015-09-17

    申请号：US14436125

    申请日：2013-10-18

    申请人： CEVEC PHARMACEUTICALS GMBH

    发明人： Gudrun Schiedner ,  Bodo Plachter

    IPC分类号： C07K14/005 ,  G01N33/569 ,  C12N7/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16123 ,  C12N2710/16134 ,  C12N2710/16151 ,  G01N33/56994 ,  G01N2333/045 ,  G01N2469/20

    摘要： The present invention relates to a method for the production of human Cytomegalovirus (HCMV) particles, the method including the steps of: (a) contacting and thereby infecting a permanent human amniocyte cell with HCMV, (b) incubating the amniocyte cell, (c) allowing expression of HCMV particles, and (d) isolating of the HCMV particles, wherein the permanent human amniocyte cell expresses the adenoviral gene products E1A and E1B and wherein the amniocyte cells are cultured in serum free medium. Furthermore, the present invention relates to HCMV particles produced by the method of the present invention as well as to a HCMV based vaccine comprising the HCMV particles, the use of the HCMV particles for use in the preparation of a HCMV based vaccine and the HCMV particles for use in the preparation of a therapeutic or diagnostic agent for the prevention or treatment of a HCMV related disease.

    摘要翻译： 本发明涉及一种生产人巨细胞病毒（HCMV）颗粒的方法，所述方法包括以下步骤：（a）使HCMV接触并由此感染永久性人类羊膜细胞，（b）孵育羊膜细胞，（c ），并且（d）分离HCMV颗粒，其中永久性人羊膜细胞表达腺病毒基因产物E1A和E1B，并且其中所述羊水细胞细胞在无血清培养基中培养。 此外，本发明涉及通过本发明的方法制备的HCMV颗粒以及包含HCMV颗粒的基于HCMV的疫苗，使用HCMV颗粒用于制备基于HCMV的疫苗和HCMV颗粒 用于制备用于预防或治疗HCMV相关疾病的治疗剂或诊断剂。