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    Cold-adapted equine influenza viruses
    3.
    发明申请
    Cold-adapted equine influenza viruses 有权

    公开(公告)号：US20040234553A1

    公开(公告)日：2004-11-25

    申请号：US10872014

    申请日：2004-06-18

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K039/145 ,  C12N007/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaption.

    Cold-adapted equine influenza viruses
    4.
    发明授权
    Cold-adapted equine influenza viruses 有权

    公开(公告)号：US06579528B1

    公开(公告)日：2003-06-17

    申请号：US09762861

    申请日：2001-08-24

    申请人： Patricia W. Dowling ,  Julius S. Youngner

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K39145

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

    Cold-adapted equine influenza viruses
    6.
    发明授权
    Cold-adapted equine influenza viruses 有权
    冷适应性马流感病毒

    公开(公告)号：US07201909B2

    公开(公告)日：2007-04-10

    申请号：US10872014

    申请日：2004-06-18

    申请人： Patricia W. Dowling ,  Julius S. Youngner

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K39/145

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaption.

    摘要翻译： 本发明提供实验产生的冷适应马流感病毒和包含这种马流感病毒的至少一个基因组片段的重配甲型流感病毒，其中马流感病毒基因组片段赋予冷适应性的至少一种鉴定表型 马流感病毒，如冷适应，温度敏感性，显性干扰或衰减。 将这样的病毒配制成治疗组合物以保护动物免受甲型流感病毒引起的疾病，特别是保护马免受马流感病毒引起的疾病。 本发明还包括利用所要求保护的治疗组合物保护动物免受由甲型流感病毒引起的疾病的方法。 这样的方法包括使用治疗组合物作为疫苗，在暴露于有毒病毒之前在动物中产生保护性免疫应答，并且使用治疗组合物作为最近感染有毒性病毒的动物的治疗，或者是 可能随后在几天内暴露于毒性病毒，由此即使没有免疫，治疗组合物也会干扰毒性病毒的生长。 本发明还提供了产生冷适应马流感病毒的方法，以及具有通过冷适应产生的马流感病毒的至少一个基因组片段的重配甲型流感病毒。

    Cold-adapted equine influenza viruses
    7.
    发明授权
    Cold-adapted equine influenza viruses 有权
    冷适应性马流感病毒

    公开(公告)号：US07074414B2

    公开(公告)日：2006-07-11

    申请号：US10181585

    申请日：2001-02-16

    申请人： Patricia W. Dowling ,  Julius S. Youngner

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K39/145 ,  A61K39/12 ,  C07K14/11

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent viruses in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

    摘要翻译： 本发明提供实验产生的冷适应马流感病毒和包含这种马流感病毒的至少一个基因组片段的重配甲型流感病毒，其中马流感病毒基因组片段赋予冷适应性的至少一种鉴定表型 马流感病毒，如冷适应，温度敏感性，显性干扰或衰减。 将这样的病毒配制成治疗组合物以保护动物免受甲型流感病毒引起的疾病，特别是保护马免受马流感病毒引起的疾病。 本发明还包括利用所要求保护的治疗组合物保护动物免受由甲型流感病毒引起的疾病的方法。 这样的方法包括使用治疗组合物作为疫苗，在暴露于有毒病毒之前在动物中产生保护性免疫应答，并且使用治疗组合物作为最近感染有毒性病毒的动物的治疗，或者是 可能随后在几天内暴露于毒性病毒，即使在没有免疫力的情况下，治疗组合物也会干扰有毒病毒的生长。 本发明还提供了产生冷适应马流感病毒的方法，以及具有通过冷适应产生的马流感病毒的至少一个基因组片段的重配甲型流感病毒。

    Cold-adapted equine influenza viruses
    8.
    发明授权
    Cold-adapted equine influenza viruses 有权

    公开(公告)号：US06685946B2

    公开(公告)日：2004-02-03

    申请号：US10065133

    申请日：2002-09-19

    申请人： Patricia W. Dowling ,  Julius S. Youngner

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K39145

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

    Cold-adapted equine influenza viruses
    9.
    发明申请
    Cold-adapted equine influenza viruses 有权

    公开(公告)号：US20030180322A1

    公开(公告)日：2003-09-25

    申请号：US10180633

    申请日：2002-06-26

    发明人： Paticia W. Dowling ,  Julius S. Youngner

    IPC分类号： C12P021/06 ,  C12P019/34 ,  A61K039/12

    CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

    Cold-adapted equine influenza viruses
    10.
    发明授权
    Cold-adapted equine influenza viruses 有权
    冷适应性马流感病毒

    公开(公告)号：US06482414B1

    公开(公告)日：2002-11-19

    申请号：US09506286

    申请日：2000-02-16

    申请人： Patricia W. Dowling ,  Julius S. Youngner

    发明人： Patricia W. Dowling ,  Julius S. Youngner

    IPC分类号： A61K39145

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16164

    摘要： The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to a virulent virus, and using a therapeutic composition as a treatment for an animal that has been recently infected with a virulent virus, or is likely to be subsequently exposed to virulent virus in a few days whereby the therapeutic composition interferes with the growth of the virulent virus, even in the absence of immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

    摘要翻译： 本发明提供实验产生的冷适应马流感病毒和包含这种马流感病毒的至少一个基因组片段的重配甲型流感病毒，其中马流感病毒基因组片段赋予冷适应性的至少一种鉴定表型 马流感病毒，如冷适应，温度敏感性，显性干扰或衰减。 将这样的病毒配制成治疗组合物以保护动物免受甲型流感病毒引起的疾病，特别是保护马免受马流感病毒引起的疾病。 本发明还包括利用所要求保护的治疗组合物保护动物免受由甲型流感病毒引起的疾病的方法。 这样的方法包括使用治疗组合物作为疫苗，在暴露于有毒病毒之前在动物中产生保护性免疫应答，并且使用治疗组合物作为最近感染有毒性病毒的动物的治疗，或者是 可能随后在几天内暴露于毒性病毒，由此即使没有免疫，治疗组合物也会干扰毒性病毒的生长。 本发明还提供了产生冷适应马流感病毒的方法，以及具有通过冷适应产生的马流感病毒的至少一个基因组片段的重配甲型流感病毒。