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    ADAPTABLE MODIFIED VIRUS VECTOR TO DELIVER MODIFIED MESSENGER RIBONUCLEIC ACID AS A MEDICAL TREATMENT DEVICE TO MANAGE DIABETES MELLITUS AND OTHER PROTEIN DEFICIENT DISEASES
    3.
    发明申请
    ADAPTABLE MODIFIED VIRUS VECTOR TO DELIVER MODIFIED MESSENGER RIBONUCLEIC ACID AS A MEDICAL TREATMENT DEVICE TO MANAGE DIABETES MELLITUS AND OTHER PROTEIN DEFICIENT DISEASES 审中-公开
    适应性改良的病毒载体，以提供改良的信使作为医疗处理设备来治疗糖尿病和其他蛋白质缺乏性疾病

    公开(公告)号：US20110070289A1

    公开(公告)日：2011-03-24

    申请号：US12562172

    申请日：2009-09-18

    申请人： LANE BERNARD SCHEIBER, II ,  LANE BERNARD SCHEIBER

    发明人： LANE BERNARD SCHEIBER, II ,  LANE BERNARD SCHEIBER

    IPC分类号： A61K9/127 ,  A61K45/00 ,  A61K31/7105 ,  A61P3/10

    CPC分类号： A61K31/7105 ,  A61K9/127 ,  A61K9/1271 ,  A61K35/76 ,  A61K47/6901 ,  C12N15/86 ,  C12N2770/24245

    摘要： Diabetes mellitus is a disease of elevated blood glucose, often directly related to a deficiency in insulin production or insulin receptor production. The innovative strategy of treatment described here utilizes modified viruses and virus-like vehicles to act as a transport mechanism to deliver modified messenger RNA molecules to target cells in the body. Delivering to the Beta cells in the body the modified messenger RNA needed to construction of insulin or insulin receptors will lead to enhanced production of biologically active insulin or insulin receptors by Beta cells as necessary, which will lead to correcting deficiencies in insulin or insulin receptors the result of which will help properly regulate blood glucose levels throughout the body utilizing innate regulatory mechanisms.

    摘要翻译： 糖尿病是血糖升高的疾病，通常与胰岛素产生或胰岛素受体产生缺乏直接相关。 这里描述的治疗创新策略利用改良的病毒和病毒样载体作为传递机制，将修饰的信使RNA分子递送到体内目标细胞。 在身体中提供β细胞后，建立胰岛素或胰岛素受体所需的修饰的信使RNA将导致β-细胞必要时增强生物活性胰岛素或胰岛素受体的产生，这将导致胰岛素或胰岛素受体缺陷的纠正 结果将有助于适当地调节整个身体的血糖水平利用先天的调节机制。