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    T1R TASTE RECEPTORS AND GENES ENCODING SAME
    6.
    发明申请
    T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
    T1R TASTE受体和编码它们的基因

    公开(公告)号：US20150322132A1

    公开(公告)日：2015-11-12

    申请号：US14715168

    申请日：2015-05-18

    Applicant: SENOMYX, INC.

    Inventor： Jon Elliot ADLER ,  Xiaodong Li ,  Lena Luukkonen ,  Shawn O'Connell ,  Sergey Zozulya

    IPC: C07K14/72 ,  G06F19/12 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/74

    CPC classification number: C07K14/723 ,  C07K14/705 ,  C07K2319/00 ,  C12Q1/6883 ,  G01N33/5041 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/726 ,  G06F19/12

    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

    Abstract translation: 描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。 具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。 还描述了用于表示哺乳动物中特定味觉刺激的味觉感知的方法，以及用于产生哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。 此外，还公开了哺乳动物刺激或阻止味觉的方法。

    T1R TASTE RECEPTORS AND GENES ENCODING SAME
    8.
    发明申请
    T1R TASTE RECEPTORS AND GENES ENCODING SAME 审中-公开
    T1R TASTE受体和编码它们的基因

    公开(公告)号：US20150299293A1

    公开(公告)日：2015-10-22

    申请号：US14696896

    申请日：2015-04-27

    Applicant: Senomyx, Inc.

    Inventor： Jon Elliot ADLER ,  Sergey Zozulya ,  Xiaodong LI ,  Shawn O'CONNELL ,  Lena STASZEWSKI

    IPC: C07K14/72

    CPC classification number: C07K14/723 ,  C07K14/705 ,  C07K2319/00

    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

    Abstract translation: 描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。 具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。 还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。 此外，还公开了哺乳动物刺激或阻止味觉的方法。

    T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    9.
    发明申请
    T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS 审中-公开

    公开(公告)号：US20190086393A1

    公开(公告)日：2019-03-21

    申请号：US16130319

    申请日：2018-09-13

    Applicant: Senomyx, Inc.

    Inventor： Mark ZOLLER ,  Xiaodong LI ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

    IPC: G01N33/50 ,  C12Q1/6876 ,  G01N33/566 ,  C07K14/705

    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3;under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

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