公开(公告)号：US20230332195A1

公开(公告)日：2023-10-19

申请号：US17768834

申请日：2020-10-09

申请人： RIVER STONE BIOTECH APS

发明人： Angela De CARVALHO ,  Swee Chuang Lim HALLWYL ,  Esben Halkjaer HANSEN ,  Jens HOUGHTON-LARSEN

IPC分类号： C12P17/18 ,  C12N15/52 ,  C12N9/02 ,  C12N9/88 ,  C12N9/06 ,  C12N15/79

CPC分类号： C12P17/18 ,  C12N15/52 ,  C12N9/0071 ,  C12N9/88 ,  C12N9/0028 ,  C12N15/79 ,  C12Y114/16002 ,  C12Y402/01078 ,  C12Y114/19 ,  C12Y105/01027

摘要： The invention relate to genetically modified hosts cell comprising a pathway having enhanced production of one or more benzylisoquinoline alkaloids wherein the cell expresses heterologous insect genes encoding insect demethylases converting thebaine into northebaine, thebaine into oripavine, thebaine into nororipavine and/or oripavine into nororipavine.