公开(公告)号：US12023373B2

公开(公告)日：2024-07-02

申请号：US17421898

申请日：2020-01-10

申请人： EXPRES2ION BIOTECHNOLOGIES APS

发明人： Stine Broch Clemmensen ,  Teit Max Moscote Søgaard ,  Willem Adriaan De Jongh

IPC分类号： A61K39/00 ,  A61K38/17 ,  A61K39/39 ,  A61P31/14 ,  C07K14/71 ,  C12N9/10 ,  C12N15/81 ,  C12N15/85 ,  C12P21/00

CPC分类号： A61K39/001106 ,  A61K38/1741 ,  A61K39/39 ,  A61P31/14 ,  C07K14/71 ,  C12N9/1051 ,  C12N15/815 ,  C12N15/85 ,  C12P21/005 ,  C12Y204/01152 ,  A61K2039/5258 ,  C12Y204/01065

摘要： Disclosed are immunization antigens that have been glyco-engineered to include non-native glycosylation patterns with a view to enhance their properties as antigens for use in such areas as vaccination and antibody production. Also disclosed are to means and methods for producing the glycomodified antigens as well of methods and uses of the glycomodified antigens.

公开(公告)号：US20240191270A1

公开(公告)日：2024-06-13

申请号：US18555611

申请日：2022-04-15

申请人： INBIOSE N.V.

发明人： Joeri Beauprez ,  Pieter Coussement ,  Thomas Decoene

IPC分类号： C12P19/12 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P19/26

CPC分类号： C12P19/12 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/1241 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/52 ,  C12P19/26 ,  C12Y101/01271 ,  C12Y203/03009 ,  C12Y204/01038 ,  C12Y204/01069 ,  C12Y204/01152 ,  C12Y207/01006 ,  C12Y207/01052 ,  C12Y207/07023 ,  C12Y207/0703 ,  C12Y207/07043 ,  C12Y401/03001 ,  C12Y402/01047 ,  C12Y504/02008 ,  C12Y504/0201 ,  C12Y602/01001

摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of metabolically engineered cells and use of said cell in a cultivation, preferably a fermentation. The present invention describes a cell for the production of a compound. The cell comprises a pathway for the production of the compound, which can be a disaccharide, oligosaccharide and/or a Neu(n)Ac-containing bioproduct, wherein (n) is 4, 5, 7, 8 or 9 or a combination thereof. The cell is metabolically engineered for enhanced synthesis of acetyl-Coenzyme A. The invention also resides in a method of producing such compound by cultivation, preferably a fermentation, with such a cell.