公开(公告)号：US20120058943A1

公开(公告)日：2012-03-08

申请号：US13131295

申请日：2008-11-28

申请人： Carsten Werner ,  Uwe Freudenberg ,  Dorit Meinhold ,  Marie-Francoise Gouzy ,  Petra Welzel

发明人： Carsten Werner ,  Uwe Freudenberg ,  Dorit Meinhold ,  Marie-Francoise Gouzy ,  Petra Welzel

IPC分类号： A61K38/18 ,  B29D7/01 ,  A61K47/42 ,  A61K47/36 ,  C12N5/071 ,  A61L31/06

CPC分类号： A61K9/107 ,  A61K31/727 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  C08B37/0075 ,  C08B37/0081 ,  C08J3/075 ,  C08J3/246 ,  C08J5/18 ,  C08J2305/10 ,  C08J2371/02 ,  C08L5/10

摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.

摘要翻译： 本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。

公开(公告)号：US20190216724A1

公开(公告)日：2019-07-18

申请号：US16333627

申请日：2017-09-15

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Xiaochu Ding ,  Jin Gao ,  Yadong Wang

IPC分类号： A61K9/00 ,  A61K47/24 ,  A61K31/727 ,  A61K38/18 ,  A61L27/20 ,  A61L27/44 ,  A61L27/54 ,  A61L27/52

CPC分类号： A61K9/0024 ,  A61K9/06 ,  A61K31/727 ,  A61K38/1825 ,  A61K47/02 ,  A61K47/24 ,  A61K47/36 ,  A61L27/10 ,  A61L27/20 ,  A61L27/446 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/34 ,  C08J3/075 ,  C08J2305/10 ,  C08L5/10

摘要： A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.

公开(公告)号：US20140377330A1

公开(公告)日：2014-12-25

申请号：US14479573

申请日：2014-09-08

申请人： Zetascience GmbH

发明人： Carsten Werner ,  Uwe Freudenberg ,  Dorit Meinhold ,  Marie-Francoise Gouzy ,  Petra Welzel

IPC分类号： A61K9/107 ,  A61K31/727

CPC分类号： A61K9/107 ,  A61K31/727 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  C08B37/0075 ,  C08B37/0081 ,  C08J3/075 ,  C08J3/246 ,  C08J5/18 ,  C08J2305/10 ,  C08J2371/02 ,  C08L5/10

摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.

摘要翻译： 本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。

公开(公告)号：US20230407016A1

公开(公告)日：2023-12-21

申请号：US18027712

申请日：2021-09-21

申请人： RENSSELAER POLYTECHNIC INSTITUTE ,  OTSUKA PHARMACEUTICAL FACTORY, INC. ,  OTSUKA CHEMECAL CO., LTD.

发明人： Pengyu XU

IPC分类号： C08J3/28 ,  C08J3/03 ,  A23L33/125 ,  A61K8/73

CPC分类号： C08J3/28 ,  C08J3/03 ,  A23L33/125 ,  A61K8/735 ,  A61K2800/82 ,  C08J2305/06 ,  C08J2305/10 ,  A61K2800/81 ,  C08J2305/08

摘要： A liquid material including a polysaccharide is manufactured by creating a mixture of polysaccharides and an aqueous solvent or an aqueous cosolvent with organic solvents at a temperature at which gelation does not occur. The mixture is also irradiated at this lower temperature, such as with ultrasound waves in combination with stirring and/or bubbling of inert gases. to apply ultrasound to a mixture of. Compared with conventional reactions with low concentration solutions, the product yield and advantageous mechanical properties are significantly increased. Depolymerization (decomposition, disassembly) of polysaccharide in the liquid material does not occur to any substantial degree, and the molecular structure of the polysaccharide is maintained. Further, the liquid material does not gel even when the temperature is raised, and thus, its fluidity is maintained, despite polysaccharides being maintained at a high concentration. The liquid material is applicable to myriad industries, including pharmaceuticals and health foods.

公开(公告)号：US20230340552A1

公开(公告)日：2023-10-26

申请号：US18135614

申请日：2023-04-17

申请人： OPTIMVIA, LLC

发明人： Tarsis Ferriera Gesteira ,  Daniel H. Lajiness

IPC分类号： C12P19/04 ,  A61K31/727 ,  C12N9/10 ,  C12N9/90 ,  C08B37/00 ,  C08J11/10

CPC分类号： C12P19/04 ,  A61K31/727 ,  C08B37/0003 ,  C08B37/0075 ,  C08J11/105 ,  C12N9/13 ,  C12N9/90 ,  C08J2305/10 ,  C12Y208/02008 ,  C12Y208/02023 ,  C12Y501/03017

摘要： The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors. Suitable aryl sulfate compounds include, but are not limited to, p-nitrophenyl sulfate or 4-nitrocatechol sulfate. Anticoagulant polysaccharides produced by methods of the present invention comprise N—, 3—O—, 6-O-sulfated glucosamine residues and 2-O sulfated hexuronic acid residues, have comparable anticoagulant activity compared to commercially-available anticoagulant polysaccharides, and can be utilized to form truncated anticoagulant polysaccharides having a reduced molecular weight.

公开(公告)号：US09642914B2

公开(公告)日：2017-05-09

申请号：US13600715

申请日：2012-08-31

申请人： Eben Alsberg ,  Oju Jeon

发明人： Eben Alsberg ,  Oju Jeon

IPC分类号： A61K47/36 ,  A61L27/52 ,  A61L27/58 ,  A61L27/38 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08K5/17

CPC分类号： A61K47/36 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1866 ,  A61K38/1875 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/52 ,  A61L27/58 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J2300/16 ,  C08J2305/04 ,  C08J2305/10 ,  C08K5/175

摘要： A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.

公开(公告)号：US20170080123A1

公开(公告)日：2017-03-23

申请号：US15347595

申请日：2016-11-09

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Paris 7 - Denis Diderot

发明人： Catherine Le Visage ,  Didier Letourneur

IPC分类号： A61L27/20 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L27/56 ,  A61L27/54

CPC分类号： A61L27/20 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08J9/08 ,  C08J9/28 ,  C08J9/283 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/04 ,  C08J2305/08 ,  C08J2305/10 ,  C08J2305/12 ,  C12N5/0068 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74

摘要： The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

公开(公告)号：US20160208064A1

公开(公告)日：2016-07-21

申请号：US14910930

申请日：2014-08-22

申请人： DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD.

发明人： Yasuyuki ISONO ,  Yasuharu NOISHIKI

IPC分类号： C08J7/14 ,  A61K47/36 ,  A61L27/20 ,  A61L27/50 ,  C08J5/18 ,  A61L31/04

CPC分类号： C08J7/14 ,  A61K8/733 ,  A61K8/735 ,  A61K8/736 ,  A61K47/36 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L31/042 ,  A61L31/16 ,  A61L2300/602 ,  C08J5/18 ,  C08J2301/26 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2305/08 ,  C08J2305/10 ,  C08L5/04 ,  C08L5/06 ,  C08L5/08 ,  C08L5/10

摘要： A process for producing a water-insoluble shaped material, including a step of treating a raw material shaped material containing a water-soluble salt of a polyanionic polysaccharide with a treatment liquid containing an acid anhydride to insolubilize the raw material shaped material in water, and the process makes it possible to simply produce a water-insoluble shaped material in which intrinsic characteristics of the polyanionic polysaccharide being a raw material are retained, which has a high safety in that a chemical crosslinking agent is not required, and which is useful as a medical material, a food material, a cosmetic material, and the like.

摘要翻译： 一种水不溶性成型材料的制造方法，其特征在于，包括：将含有聚阴离子多糖的水溶性盐的原料成型材料与含有酸酐的处理液进行处理以使原料成型材料在水中不溶化的工序;以及 该方法使得可以简单地生产其中保留作为原料的聚阴离子多糖的固有特性的水不溶性成型材料，其具有高安全性，因为不需要化学交联剂，并且其可用作 医疗材料，食品材料，化妆品等。

公开(公告)号：US20150005395A1

公开(公告)日：2015-01-01

申请号：US14367906

申请日：2012-10-04

申请人： OSSTEMIMPLANT CO., LTD.

发明人： Yong Il Chung ,  Da Mi Choi ,  Ju Dong Song ,  Eun Jung Kang ,  Tae Gwan Eom ,  Kyoo Ok Choi

IPC分类号： A61L27/58 ,  B29C35/02 ,  A61L27/22 ,  B29C39/00 ,  A61L27/24 ,  A61L27/18

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/227 ,  A61L27/24 ,  A61L2430/12 ,  B29C35/02 ,  B29C39/003 ,  B29K2071/02 ,  B29K2105/0061 ,  B29K2995/0088 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/206 ,  C08J2301/28 ,  C08J2305/02 ,  C08J2305/04 ,  C08J2305/10 ,  C08J2371/02 ,  C08J2389/00 ,  C08J2400/206 ,  C08J2471/02 ,  C08L1/286 ,  C08L5/02 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10 ,  C08L71/02 ,  C08L89/06 ,  C08L101/16 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/04

摘要： The present invention relates to a dental hydrogel and to a method for manufacturing same, and more particularly, to a hydrogel and to a method for manufacturing wherein the hydrogel, which can be freely used during treatment irrespective of the shape of a bone defect region, has a decomposition rate capable of being regulated in situ and can thus be rapidly decomposed over a certain time, i.e., after the completion of bone regeneration. Furthermore, the present invention relates to a hydrogel membrane using the hydrogel which can be applied to a bone defect region irrespective of the shape thereof, and to a method for manufacturing same.

摘要翻译： 本发明涉及一种牙科用水凝胶及其制造方法，更具体地说，涉及一种水凝胶及其制造方法，其中可以在治疗期间自由使用的水凝胶与骨缺损区域的形状无关， 具有能够原位调节的分解速率，因此可以在一定时间内即在骨再生完成后快速分解。 此外，本发明涉及使用可以应用于骨缺损区域而不管其形状的水凝胶的水凝胶膜及其制造方法。

公开(公告)号：US08273373B2

公开(公告)日：2012-09-25

申请号：US12649700

申请日：2009-12-30

申请人： Eben Alsberg ,  Oju Jeon

发明人： Eben Alsberg ,  Oju Jeon

IPC分类号： A61K9/14 ,  A61K31/12 ,  A01N35/00 ,  A61M31/00

CPC分类号： A61K47/36 ,  A61K35/32 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1866 ,  A61K38/1875 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/52 ,  A61L27/58 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J2300/16 ,  C08J2305/04 ,  C08J2305/10 ,  C08K5/175

摘要： A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.

摘要翻译： 光交联的可生物降解的水凝胶包括与多个可水解丙烯酸酯交联的交联的多个天然聚合物大分子单体。 水凝胶是细胞相容的，并且在降解时产生基本上无毒的产物。