公开(公告)号：US20100310451A1

公开(公告)日：2010-12-09

申请号：US12740654

申请日：2008-11-03

申请人： Deborah Maret ,  David R. Colman ,  Eugenia Gruzglin ,  Nabil Seidah

发明人： Deborah Maret ,  David R. Colman ,  Eugenia Gruzglin ,  Nabil Seidah

IPC分类号： A61K51/00 ,  G01N33/574 ,  C12Q1/68 ,  A61K49/00 ,  A61K49/06

CPC分类号： A61K38/482 ,  A61K31/7105 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y304/21075 ,  C12Y304/21826 ,  G01N33/57492 ,  G01N2333/705 ,  G01N2333/96438

摘要： The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).

摘要翻译： 本发明涉及通过确定癌细胞表面的钙粘着蛋白的分子形式，在癌症的诊断和/或预后以及用于监测癌症进展和/或抗癌治疗的治疗效果的方法中 受试者的细胞。 本发明还涉及通过增加钙黏着蛋白的粘合剂形式和/或降低细胞表面的钙粘蛋白的非粘合形式来预防，抑制或治疗受试者的癌症或其转移的方法。 本发明还涉及确定弗林蛋白酶和前蛋白转化酶5A（PC5A）的表达水平的方法步骤。

公开(公告)号：US20140051832A1

公开(公告)日：2014-02-20

申请号：US14004235

申请日：2011-03-11

申请人： Marcos A. A. Demasi ,  Mari Cleide Sogayar ,  Christian Colin

发明人： Marcos A. A. Demasi ,  Mari Cleide Sogayar ,  Christian Colin

IPC分类号： C07K14/755

CPC分类号： C07K14/755 ,  C12N9/6454 ,  C12P21/06 ,  C12Y304/21826

摘要： The object of the present invention is to provide methods for the production of recombinant human Factor VIII, employing specific endoproteases, thus assuring full proteolytic processing of said factor even during its biosynthesis, consequently avoiding additional purification steps. Other objects of the present invention are the recombinant human Factor VIII as obtained by said methods, pharmaceutical compositions, related uses and therapeutic methods.

摘要翻译： 本发明的目的是提供使用特异性内切蛋白酶生产重组人因子VIII的方法，从而即使在其生物合成过程中也能保证所述因子的完全蛋白水解加工，从而避免了额外的纯化步骤。 本发明的其它目的是通过所述方法获得的重组人因子VIII，药物组合物，相关用途和治疗方法。