公开(公告)号：US5277176A

公开(公告)日：1994-01-11

申请号：US905347

申请日：1992-06-29

Applicant: Nader M. Habashi ,  Howard N. Reynolds ,  Ulf R. Borg

Inventor： Nader M. Habashi ,  Howard N. Reynolds ,  Ulf R. Borg

IPC: A61M1/16 ,  A61M1/22 ,  A61M15/00

CPC classification number: A61M1/1698 ,  A61M2202/0476 ,  Y10S128/03 ,  Y10S128/913

Abstract: An extracorporeal lung assistance device having an oxygen-containing gas chamber positioned in such relationship to a gas exchange chamber that transfer of oxygen to blood and the withdrawal of carbon dioxide from blood disposed may be made. The gas exchange chamber has a blood flow channel extending through the gas exchanger defined by a microporous membrane forming a wall separating the blood flow channel from an oxygen, carbon dioxide exchange media. A second membrane supported in spaced-apart relationship from said first membrane. The space between the membranes is filled with the oxygen carbon dioxide exchange media.

Abstract translation: 可以制造体外肺辅助装置，其具有与气体交换室相关联的含氧气体室，所述气体交换室将氧气输送到血液并且从所配置的血液中排出二氧化碳。 气体交换室具有延伸穿过由微孔膜限定的气体交换器的血流通道，所述微孔膜形成将血流通道与氧气二氧化碳交换介质分开的壁。 与所述第一膜以间隔开的关系支撑的第二膜。 膜之间的空间填充有氧二氧化碳交换介质。

公开(公告)号：US08012106B2

公开(公告)日：2011-09-06

申请号：US11252363

申请日：2005-10-17

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

IPC: A61B5/103 ,  A61B5/117 ,  A61B5/08 ,  A61M25/00

CPC classification number: A61B5/1076 ,  A61M25/0133

Abstract: A lumen measuring device generally includes a central member dimensioned to extend into a lumen and an elongate outer member having a flexible region configured to flex outward from the central member in response to retraction of the central member. In measuring a lumen, the flexible region is caused to contact the lumen. The lumen may be contacted by linear segments that hinge or by members that bow arcuately. A polygon, such as a triangle, may be defined by portions of the outer member and the central member. A handle assembly may be provided by which the disposition of the central member relative to the outer member may be adjusted. Indicators may be defined by the central member and outer member by which the disposition of the central member and by which the diameter of a lumen may be determined.

Abstract translation: 管腔测量装置通常包括尺寸适于延伸到内腔中的中心构件和具有柔性区域的细长外部构件，弹性区域构造成响应于中心构件的缩回而从中心构件向外弯曲。 在测量管腔时，使柔性区域与内腔接触。 内腔可以通过铰链或弓形弓形的线段相接触。 诸如三角形的多边形可以由外部构件和中心构件的部分限定。 可以提供手柄组件，通过该手柄组件可以调节中心构件相对于外部构件的布置。 指示器可以由中心构件和外部构件限定，通过该构件可以确定中心构件的布置并且可以确定管腔的直径。

公开(公告)号：US07875068B2

公开(公告)日：2011-01-25

申请号：US10674972

申请日：2003-09-30

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

IPC: A61F2/06

CPC classification number: A61L31/08 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/041 ,  A61F2002/065 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2230/0017 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0051

Abstract: The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents generally and a biliary stent in particular where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and/or proper installation. Additionally, the biliary stent in accordance with the present invention provides enhanced flow mechanics to ensure the adequate clearance of viscid fluids such as bile.

Abstract translation: 本发明在一个示例性实施例中提供一种支架，其结合了硅树脂和金属支架的许多优异特性，同时消除了不期望的支架。 特别地，根据本发明的主要目的是提供一般的支架系列和胆管支架，特别是其中支架区域的相对硬度/柔软度可以与支架的其它区域不同以提供额外的患者舒适度 和抗径向力。 示例性实施例还提供了具有新颖空隙配置的支架系列，其有助于灵活性，耐久性和/或适当的安装。 此外，根据本发明的胆管支架提供增强的流动力学以确保粘性流体如胆汁的足够的间隙。

公开(公告)号：US20090319021A1

公开(公告)日：2009-12-24

申请号：US12547933

申请日：2009-08-26

Applicant: Eric K. Mangiardi ,  Jason R. Reynolds ,  Ulf R. Borg

Inventor： Eric K. Mangiardi ,  Jason R. Reynolds ,  Ulf R. Borg

IPC: A61F2/06

CPC classification number: A61F2/954 ,  A61B90/30 ,  A61B90/361 ,  A61F2002/065 ,  A61F2002/9517

Abstract: The present invention, in preferred embodiments, provides delivery and deployment apparatuses for bifurcated stents capable of comfortably cradling the corina of bifurcated target tissue between the arms of the bifurcated stent as each arm of the bifurcated stent is delivered to a respective side branch. In particular, a family of apparatuses is provided that may be indicated for vascular and non-vascular intervention.Additionally, these apparatuses do not require the use of an ancillary means, such as one or more balloon catheters to achieve complete and precise deployment. In preferred embodiments, delivery and deployment devices in accordance with the present invention also provide, direct visualization, deployment safety features and enhanced physician control.

Abstract translation: 本发明在优选实施例中提供了用于分叉支架的输送和展开装置，其能够在分叉支架的臂部被递送到相应的侧支部之间时能够舒适地支撑分叉支架的臂之间的分叉靶组织的corina。 特别地，提供了可以用于血管和非血管干预的一系列装置。 另外，这些装置不需要使用诸如一个或多个气囊导管的辅助装置来实现完全和精确的部署。 在优选实施例中，根据本发明的递送和展开装置还提供直接可视化，部署安全特征和增强的医师控制。

公开(公告)号：US07959671B2

公开(公告)日：2011-06-14

申请号：US10718217

申请日：2003-11-20

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

IPC: A61F2/06

CPC classification number: A61L31/08 ,  A61F2/0077 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0018 ,  A61F2250/0051

Abstract: The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is covered so as to provide certain predefined characteristics. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent has enhanced friction points while the internal surface exemplifies certain characteristics.

Abstract translation: 本发明在一个示例性实施例中提供一种支架，其结合了硅树脂和金属支架的许多优异特性，同时消除了不期望的支架。 特别地，根据本发明的主要目的是提供支架系列，其中支架的区域的相对硬度/柔软度可以与支架的其它区域不同，以提供额外的患者舒适度和抵抗压缩力。 示例性实施例提供被覆盖以提供某些预定义特征的支架。 特别地，提供了内部涂覆的覆盖支架，使得支架的外部支架表面具有增强的摩擦点，而内表面示出了某些特性。

公开(公告)号：US07637942B2

公开(公告)日：2009-12-29

申请号：US10669450

申请日：2003-09-24

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg

IPC: A61F2/06

CPC classification number: A61L31/08 ,  A61F2/07 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/0075 ,  A61F2250/0018 ,  A61F2250/0051 ,  A61F2250/0059 ,  A61F2250/0067

Abstract: The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected. Moreover, the coating itself has anti-adherent properties such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally.

Abstract translation: 本发明在一个示例性实施例中提供一种支架，其结合了硅树脂和金属支架的许多优异特性，同时消除了不期望的支架。 特别地，根据本发明的主要目的是提供支架系列，其中支架的区域的相对硬度/柔软度可以与支架的其它区域不同，以提供额外的患者舒适度和抵抗压缩力。 示例性实施例提供了以限制与目标内腔直接接触的涂层表面积的量的方式涂覆的支架。 特别地，提供了被覆盖的支架，其被内部涂覆，使得支架的外部支架表面从涂层的外表面升高。 为此，纤毛功能仅部分受限，粘膜纤毛清除率没有明显影响。 此外，涂层本身具有抗粘附性质，使得细菌，真菌或其它微生物不能特别地定位于盖子和支架上。

公开(公告)号：US07637934B2

公开(公告)日：2009-12-29

申请号：US10404197

申请日：2003-03-31

Applicant: Eric K. Mangiardi ,  Ulf R. Borg ,  Jason M. Reynolds

Inventor： Eric K. Mangiardi ,  Ulf R. Borg ,  Jason M. Reynolds

IPC: A61F2/06

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2250/0091

Abstract: Embodiments of the present invention are directed to devices for allowing a user to deploy a stent in an anatomical lumen of a patient. For example, one embodiment is directed to a device including a longitudinally extending inner tubular member and a longitudinally extending outer tubular member that are longitudinally and axially displaceable relative to one another. The outer tubular member includes at least one longitudinally extending channel formed between the exterior and interior diameter of the outer tubular member. In addition, the device includes a handle configured to displace the outer tubular member and inner tubular member relative to each other in response to user intervention and a stop configured to coaxially engage the handle to form a safety mechanism. Displaceability of the outer tubular member and inner tubular member relative to each other is limited by the safety mechanism to a predetermined threshold.

Abstract translation: 本发明的实施例涉及用于允许使用者将支架部署在患者的解剖腔中的装置。 例如，一个实施例涉及一种包括纵向延伸的内管状构件和纵向延伸的外管状构件的装置，其相对于彼此纵向和轴向移位。 外部管状构件包括形成在外部管状构件的外部和内部直径之间的至少一个纵向延伸通道。 另外，该装置还包括一个手柄，该把手构造成响应于使用者介入而相对于彼此移动外部管状构件和内部管状构件，并且构造成同轴地接合手柄以形成安全机构的止动件。 外部管状构件和内部管状构件相对于彼此的可移动性被安全机构限制到预定阈值。

公开(公告)号：US08298277B2

公开(公告)日：2012-10-30

申请号：US12617165

申请日：2009-11-12

Applicant: Eric K. Mangiardi ,  Ulf R. Borg ,  Jason M Reynolds

Inventor： Eric K. Mangiardi ,  Ulf R. Borg ,  Jason M Reynolds

IPC: A61F2/06

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2250/0091

Abstract: Embodiments of the present invention are directed to devices for allowing a user to deploy a stent in an anatomical lumen of a patient. For example, one embodiment is directed to a device including a longitudinally extending inner tubular member and a longitudinally extending outer tubular member that are longitudinally and axially displaceable relative to one another. The outer tubular member includes at least one longitudinally extending channel formed between the exterior and interior diameter of the outer tubular member. In addition, the device includes a handle configured to displace the outer tubular member and inner tubular member relative to each other in response to user intervention and a stop configured to coaxially engage the handle to form a safety mechanism. Displaceability of the outer tubular member and inner tubular member relative to each other is limited by the safety mechanism to a predetermined threshold.

Abstract translation: 本发明的实施例涉及用于允许使用者将支架部署在患者的解剖腔中的装置。 例如，一个实施例涉及一种包括纵向延伸的内管状构件和纵向延伸的外管状构件的装置，其相对于彼此纵向和轴向移位。 外部管状构件包括形成在外部管状构件的外部和内部直径之间的至少一个纵向延伸通道。 另外，该装置还包括一个手柄，该把手构造成响应于使用者介入而相对于彼此移动外部管状构件和内部管状构件，并且构造成同轴地接合手柄以形成安全机构的止挡件。 外部管状构件和内部管状构件相对于彼此的可移动性被安全机构限制到预定阈值。

公开(公告)号：US08206436B2

公开(公告)日：2012-06-26

申请号：US12616455

申请日：2009-11-11

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg

IPC: A61F2/06

CPC classification number: A61L31/08 ,  A61F2/07 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/0075 ,  A61F2250/0018 ,  A61F2250/0051 ,  A61F2250/0059 ,  A61F2250/0067

Abstract: The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected. Moreover, the coating itself has anti-adherent properties such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally.

Abstract translation: 本发明在一个示例性实施例中提供一种支架，其结合了硅树脂和金属支架的许多优异特性，同时消除了不期望的支架。 特别地，根据本发明的主要目的是提供支架系列，其中支架的区域的相对硬度/柔软度可以与支架的其它区域不同，以提供额外的患者舒适度和抵抗压缩力。 示例性实施例提供了以限制与目标内腔直接接触的涂层表面积的量的方式涂覆的支架。 特别地，提供了被覆盖的支架，其被内部涂覆，使得支架的外部支架表面从涂层的外表面升高。 为此，纤毛功能仅部分受限，粘膜纤毛清除率没有明显影响。 此外，涂层本身具有抗粘附性质，使得细菌，真菌或其它微生物不能特别地定位于盖子和支架上。

公开(公告)号：US08083692B2

公开(公告)日：2011-12-27

申请号：US12898213

申请日：2010-10-05

Applicant: Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

Inventor： Eric K. Mangiardi ,  Jason M. Reynolds ,  Ulf R. Borg ,  Tony D. Alexander

IPC: A61B5/103 ,  A61B1/00

CPC classification number: A61B5/103 ,  A61B5/1076 ,  A61B5/6853 ,  A61B5/6858

Abstract: The present invention provides a lumen measuring device and method that allows the user to calculate the exact length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure.

Abstract translation: 本发明提供了一种流明测量装置和方法，其允许用户在相同的探索过程期间计算合适的介入假体的精确长度和直径以及狭窄的高度和长度。