Effervescent composition and method of making it

    公开(公告)号:US11576855B2

    公开(公告)日:2023-02-14

    申请号:US17445918

    申请日:2021-08-25

    摘要: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

    Fractional lobe processor
    5.
    发明授权

    公开(公告)号:US11465327B1

    公开(公告)日:2022-10-11

    申请号:US15760583

    申请日:2017-04-24

    摘要: A fractional lobe processor comprises a barrel with heating and cooling means having two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore; a shaft coupled with a plurality of screw elements to form a screw within each bore, wherein the screws are intermeshing and form at least three zones within the barrel, the zones comprising an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a feed comprising an active substance and/or an excipient, a melt zone consisting of only fractional lobe elements for melting the active substance and/or an excipient to form a viscous mass or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the intake zone; and wherein the melt zone has a plurality of fractional lobe elements on each shaft.

    PROCESSOR AND A PROCESS FOR GRANULATION OF POWDERS

    公开(公告)号:US20190134875A1

    公开(公告)日:2019-05-09

    申请号:US16095306

    申请日:2017-04-24

    摘要: A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.

    CONTINUOUS GRANULATION SYSTEM AND METHOD FOR OBTAINING CONDITIONED GRANULES

    公开(公告)号:US20230226723A1

    公开(公告)日:2023-07-20

    申请号:US18016246

    申请日:2021-07-14

    摘要: A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.