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    Colon cleansing compositions and methods
    1.
    发明申请
    Colon cleansing compositions and methods 有权
    结肠清洗组合物和方法

    公开(公告)号：US20040143005A1

    公开(公告)日：2004-07-22

    申请号：US10693328

    申请日：2003-10-24

    Applicant: NORGINE EUROPE BV

    Inventor： Norman Barras ,  Ian David Cox

    IPC: A61K031/375 ,  A61K031/08

    CPC classification number: A61K9/009 ,  A61K9/0095 ,  A61K31/375 ,  A61K31/765 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/14 ,  A61K45/06 ,  Y10S514/892 ,  A61K2300/00

    Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

    Abstract translation: 一种组合物，其包含每升水溶液30至350g聚乙二醇，3至20g抗坏血酸组分，选自抗坏血酸，抗坏血酸盐或其混合物，碱 金属或碱土金属硫酸盐，优选其1至15g，以及任选的一种或多种选自氯化钠，氯化钾和碳酸氢钠的电解质，并且优选还包含调味剂，在清洁肠道中有效，以制备 内镜检查，特别是结肠镜检查。 它比常规磷酸钠基肠清洁组合物更安全，因此可用于使用基于磷酸钠的组合物处于危险中的患者，并且比常规的基于PEG的组合物更耐受，导致更好的患者依从性和使能 有效的门诊使用。

    Non-fermented osmotic laxative and method for treating and preventing colorectal cancers
    3.
    发明申请
    Non-fermented osmotic laxative and method for treating and preventing colorectal cancers 失效
    非发酵渗透性泻药及治疗和预防结肠直肠癌的方法

    公开(公告)号：US20010051659A1

    公开(公告)日：2001-12-13

    申请号：US09836971

    申请日：2001-04-18

    Inventor： Denis Corpet ,  Sylviane Tache ,  Geraldine Parnaud

    IPC: A61K031/08

    CPC classification number: A61K31/765 ,  A61K31/77 ,  Y10S514/892

    Abstract: Use of a non-fermented osmotic laxative as an active agent for preparation of a medicinal product for treating and/or preventing colon and/or rectum cancers. A method of treating or preventing colon or rectum cancer comprising administering to a mammal a therapeutically effective amount of a non-fermented osmotic laxative.

    Abstract translation: 使用非发酵渗透性泻药作为制备用于治疗和/或预防结肠癌和/或直肠癌的药物的活性剂。 一种治疗或预​​防结肠癌或直肠癌的方法，包括向哺乳动物施用治疗有效量的非发酵渗透性泻药。

    Polynucleotide formulation for enhanced intracellular transfer
    4.
    发明申请
    Polynucleotide formulation for enhanced intracellular transfer 审中-公开
    用于增强细胞内转移的多核苷酸制剂

    公开(公告)号：US20040132676A1

    公开(公告)日：2004-07-08

    申请号：US10467714

    申请日：2004-03-17

    Inventor： Bruno Pitard

    IPC: A61K048/00 ,  A61K031/08

    CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K48/00 ,  C12N15/87

    Abstract: The invention relates to a pharmaceutical composition comprising a polynucleotide and at least 2% (weight/volume), preferably 2 to 10%, of a nonionic copolymer of formula (I)OH(CH2CH2O)a(CH(CH3)CH2O)a(CH2CH2O)cH, in which a, b, and c are such that the polyoxypropylene portion has a molecular weight of between 1450 and 2050, and the polyoxyethylene portions constitute between 75 and 85% (weight:weight) of the copolymer. The composition is preferably free of cationic lipid or of sodium phosphate. The copolymer is intended to improve the transfer of the polynucleotide into, or the expression of the polynucleotide in, eukaryotic cells. A typical example of a copolymer corresponding to formula (I) is F68. A composition according to the invention is in particular useful in the gene therapy, vaccination and immunotherapy fields.

    Abstract translation: 本发明涉及一种药物组合物，其包含多核苷酸和至少2％（重量/体积），优选2至10％的式（I）OH（CH 2 CH 2 O）a（CH（CH 3）CH 2 O）a CH2CH2O）cH，其中a，b和c使聚氧丙烯部分的分子量为1450〜2050，聚氧乙烯部分占共聚物的75〜85％（重量）。 组合物优选不含阳离子脂质或磷酸钠。 共聚物旨在改善多核苷酸在真核细胞中的转移或多核苷酸的表达。 对应于式（I）的共聚物的典型实例是F68。 根据本发明的组合物特别可用于基因治疗，疫苗接种和免疫治疗领域。

    Suppression of human activity in an enclosed space
    5.
    发明申请
    Suppression of human activity in an enclosed space 审中-公开
    在封闭的空间中抑制人类活动

    公开(公告)号：US20030232064A1

    公开(公告)日：2003-12-18

    申请号：US10272922

    申请日：2002-10-17

    Inventor： William H. Burns JR. ,  John C. McNeirney

    IPC: A61K031/08 ,  A01N025/00

    CPC classification number: A61K31/08

    Abstract: The present invention provides a method for suppressing human activity in enclosed spaces. More particularly, the invention provides a method for the introduction of anesthesia into an enclosed space for the purpose of rendering occupants of the enclosed space unconscious.

    Abstract translation: 本发明提供一种抑制封闭空间中的人体活动的方法。 更具体地，本发明提供了一种用于将麻醉引入封闭空间中以使无意识的封闭空间的乘客的目的的方法。

    Ophthalmic composition
    6.
    发明申请
    Ophthalmic composition 失效

    公开(公告)号：US20030022943A1

    公开(公告)日：2003-01-30

    申请号：US09833621

    申请日：2001-04-13

    Applicant: Menicon Co., Ltd.

    Inventor： Akira Tsuzuki ,  Sadayasu Tanikawa

    IPC: A61K031/08

    CPC classification number: A61L12/14 ,  Y10S514/912

    Abstract: An ophthalmic composition which contains a component A consisting of at least one member selected from the group consisting of polyoxyalkylene block copolymers and their derivatives, and a component B consisting of at least one member selected from the group consisting of glycyrrhizic acid and its salts.

    Compositions and methods for coloring hair
    7.
    发明申请
    Compositions and methods for coloring hair 审中-公开
    头发着色的组成和方法

    公开(公告)号：US20010002254A1

    公开(公告)日：2001-05-31

    申请号：US09768485

    申请日：2001-01-25

    Applicant: Revlon Consumer Products Corporation

    Inventor： Dalal Ibrahim Duffer ,  Teresita Vergaria Imperial

    IPC: A61K007/06 ,  A61K007/075 ,  A61K007/11 ,  A01N039/00 ,  A01N031/14 ,  A61K031/08 ,  A61K033/40 ,  A61K007/08 ,  A61K007/13

    CPC classification number: A61Q5/10 ,  A61K8/604 ,  A61K8/8152

    Abstract: A developer composition having a pH of 2.5 to 6.9, for use in oxidative dyeing of hair comprising 0.01-20% of a primary thickening agent which is an aqueous solution of acrylic polymer comprised of A and B monomers wherein the A monomer is selected from the group consisting of acrylic acid, methacrylic acid, and mixtures thereof; and the B monomer is selected from the group consisting of a C1-22 alkyl methacrylate, and a C1-22 alkyl acrylate, and mixtures thereof; 0.01-20% of a nonionic surfactant, 0.01-25% hydrogen peroxide, and 65-99.9% water; a hair dye mixture for coloring hair; a two component kit for coloring hair; and a method for coloring hair.

    Abstract translation: 一种用于头发氧化染色的显影剂组合物，其包含0.01-20％的初级增稠剂，其是由A和B单体组成的丙烯酸类聚合物的水溶液，其中A单体选自 由丙烯酸，甲基丙烯酸及其混合物组成的组; B单体选自甲基丙烯酸C1-22烷基酯和丙烯酸C1-22烷基酯及其混合物; 0.01-20％的非离子表面活性剂，0.01-25％的过氧化氢和65-99.9％的水; 用于染发的染发混合物; 用于染发的双组分试剂; 和一种染发的方法。

    Stabilized formulations of adenovirus
    9.
    发明申请
    Stabilized formulations of adenovirus 审中-公开
    腺病毒的稳定制剂

    公开(公告)号：US20030232018A1

    公开(公告)日：2003-12-18

    申请号：US10342344

    申请日：2003-01-15

    Applicant: BERLEX BIOSCIENCES ,  Schering AG

    Inventor： Elisabeth Lehmberg ,  Erno Pungor

    IPC: A61K039/12 ,  A61L009/04 ,  A61K031/70 ,  A61K031/08

    CPC classification number: A61K47/10 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N2710/10051 ,  C12N2710/10332 ,  C12N2710/10351

    Abstract: A method is disclosed to stabilize compositions comprising airborne viruses, particularly Adenoviruses; and more particularly recombinant Adenoviruses, by adding to the compositions a non-ionic detergent which comprises an alkyl moiety and a polyethylene glycol (PEG). Pharmaceutical and other compositions of Adenoviruses, particularly recombinant Adenoviruses suitable for methods of gene therapy, which comprise such detergents are also disclosed.

    Abstract translation: 公开了一种稳定包含空气传播病毒，特别是腺病毒的组合物的方法; 特别是重组腺病毒，通过向组合物中加入包含烷基部分和聚乙二醇（PEG）的非离子型洗涤剂。 还公开了腺病毒的药物和其它组合物，特别是适用于包含这种洗涤剂的基因治疗方法的重组腺病毒。

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