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173 条记录 (耗时 0.028 秒)

    Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
    2.
    发明申请
    Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis 有权
    用于治疗皱纹，细纹和多汗症的组合物和递送方法

    公开(公告)号：US20040127556A1

    公开(公告)日：2004-07-01

    申请号：US10334887

    申请日：2002-12-31

    发明人： Michelle Zheng Lu ,  Robert E. Kalafsky ,  Michele C. Duggan

    IPC分类号： A61K031/365 ,  A61K031/045 ,  A61K031/01

    CPC分类号： A61Q19/08 ,  A61K8/046 ,  A61K8/14 ,  A61K8/97 ,  A61K31/00 ,  A61K31/01 ,  A61K31/045 ,  A61K31/365 ,  A61K45/06 ,  A61K2800/70 ,  A61K2300/00

    摘要： The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

    摘要翻译： 本发明描述了用于治疗，预防和改善皮肤外观，特别是治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹的组合物和方法，其中组合物包括抑制乙​​酰胆碱释放的柠檬醛成分 在骨骼肌的神经肌肉接头处，以便放松与皮肤起皱，折叠和皱纹相关的肌肉，例如面部运动和表达。 柠檬醛优选包括植物生物碱toosendanin和印苦楝子素。 也用于治疗多汗症的组合物优选施用于皮肤，或通过定向方式递送至有需要的部位。

    Potassium channel opener
    3.
    发明申请
    Potassium channel opener 失效
    钾通道开启剂

    公开(公告)号：US20040116482A1

    公开(公告)日：2004-06-17

    申请号：US10664165

    申请日：2003-09-17

    发明人： Yuji Imaizumi ,  Tomohiko Ohwada

    IPC分类号： A61K031/44 ,  A61K031/40 ,  A61K031/275 ,  A61K031/19 ,  A61K031/045 ,  A61K031/12

    CPC分类号： A61K31/19

    摘要： A potassium channel opener comprising a compound (e.g., pimaric acid) represented by the formula nullInull: 1 wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

    摘要翻译： 钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R 1，R 2，R 3，R 4，R 5，R 6 和R 7各自独立地为氢，烷基，烯基，卤素，羟基，卤代烷基，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈 ; 或R 4和R 5可以彼此键合形成环; 或R 6和R 7可以彼此键合形成环; 并且由表示的所有三个键都是单键，或者是 三键为双键，其他键为单键，或其生理学上可接受的盐作为有效成分。

    Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith
    6.
    发明申请
    Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith 失效
    治疗性1,2,3,6-四氢嘧啶-2-酮组合物及其方法

    公开(公告)号：US20030207851A1

    公开(公告)日：2003-11-06

    申请号：US10139193

    申请日：2002-05-02

    发明人： Edward T. Wei

    IPC分类号： A61K031/573 ,  A61K031/513 ,  A61K031/137 ,  A61K031/045

    CPC分类号： A61K9/0075 ,  A61K9/0043 ,  A61K31/00 ,  A61K31/513 ,  A61K31/56 ,  A61K31/573 ,  A61K45/06 ,  A61M15/08 ,  A61M2202/064 ,  A61K2300/00

    摘要： A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount and preferably further comprises one or more pharmaceutically active drugs such as an anti-inflammatory glucocorticosteroid, a sympathomimetic amine decongestant, an anti-histamine, a local anesthetic, menthol or a menthol analog, and mixtures thereof. The cold receptor agonist may be represented by the general formula 1-null1R-phenylnull-4-nullR2-phenylnull-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 is -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention elicit long-lasting cooling or soothing, particularly when formulated for delivery to suppress the sensations of itch and pain, such as for delivery to inflamed skin, to the mucous membranes of the anogenital areas, and to the enteric mucosa.

    摘要翻译： 提供了治疗组合物，其包含治疗有效量的1-R 1 - 苯基，4-R 2 - 苯基取代的1,2,3,6-四氢嘧啶-2-酮冷受体激动剂，优选还包含一种或多种药学活性 药物如抗炎糖皮质激素，拟交感胺减充血剂，抗组胺，局部麻醉剂，薄荷醇或薄荷醇类似物及其混合物。 冷受体激动剂可以由通式1- [1R-苯基] -4- [R2-苯基] -1,2,3,6-四氢嘧啶-2-酮表示，其中：R1是 - 羟基， - 氯， - 氟， - 烷基， - 乙酰氧基， - 三氟甲基; 并且R 2是 - 硝基， - 氯， - 氟， - 烷基， - 三氟甲基。 本发明的治疗组合物引起持久的冷却或舒缓，特别是当配制用于输送以抑制瘙痒和疼痛的感觉，例如用于递送至发炎的皮肤，向肛门生殖区域的粘膜和肠粘膜时。

    Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation
    7.
    发明申请
    Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation 审中-公开
    使用可溶性环氧化物水解酶抑制剂抑制血管平滑肌细胞增殖

    公开(公告)号：US20030139469A1

    公开(公告)日：2003-07-24

    申请号：US10056284

    申请日：2002-01-23

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Robert H. Weiss ,  Bruce D. Hammock

    IPC分类号： A61K031/335 ,  A61K031/17 ,  A61K031/13 ,  A61K031/045

    CPC分类号： A61K31/335 ,  A61K31/00 ,  A61K31/045 ,  A61K31/13 ,  A61K31/17

    摘要： The present invention provides methods of slowing or inhibiting vascular smooth muscle (VSM) cell proliferation to slow the development or recurrence of atherosclerosis by contacting VSM cells with soluble epoxide hydrolase (sEH) inhibitors. Further, the methods of the invention can be used to slow or to inhibit vascular restenosis after angioplasty and the stenosis of vascular stents. Further, the methods of the invention can be used to slow or to inhibit the stenosis of hemodialysis grafts and other natural and synthetic vascular grafts.

    摘要翻译： 本发明提供了通过使VSM细胞与可溶性环氧化物水解酶（sEH）抑制剂接触来减缓或抑制血管平滑肌（VSM）细胞增殖以减缓动脉粥样硬化的发展或复发的方法。 此外，本发明的方法可用于减缓或抑制血管成形术和血管支架狭窄后的血管再狭窄。 此外，本发明的方法可用于减缓或抑制血液透析移植物和其它天然和合成血管移植物的狭窄。