公开(公告)号：US07176227B2

公开(公告)日：2007-02-13

申请号：US10516158

申请日：2003-09-05

申请人： Toru Yamazaki ,  Shigeyuki Kikumoto ,  Masahiro Ono ,  Atsushi Saitou ,  Haruka Takahashi ,  Sei Kumakura ,  Kunitaka Hirose ,  Mikiro Yanaka ,  Yoshiyuki Takemura ,  Shigeru Suzuki ,  Ryo Matsui

发明人： Toru Yamazaki ,  Shigeyuki Kikumoto ,  Masahiro Ono ,  Atsushi Saitou ,  Haruka Takahashi ,  Sei Kumakura ,  Kunitaka Hirose ,  Mikiro Yanaka ,  Yoshiyuki Takemura ,  Shigeru Suzuki ,  Ryo Matsui

IPC分类号： C07D403/12 ,  A61K314/178

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n1, n2, and n3 is an integer of 1; each of R1, R2, R3, R4, R5, and R6 is independently a hydrogen atom; A1 is imidazole; A2 is imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH2; D is a group represented by -Q-Y—B, wherein Q is NR12 and R12 is a hydrogen atom or an alkyl group; Y is (CH2)m3 and m3 is an integer of 2 to 4; and B is N(R25R26), wherein each of R25 and R26 are independently a hydrogen atom, a C1–C6 alkyl group or a C3–C6 cycloalkyl group.

摘要翻译： 对HIV病毒感染，风湿病，癌症转移等有害的新型胺化合物，可以举出以下通式（1）表示的化合物，其药理学上可接受的盐或其前药：其中，n， 1 1，n 2和n 3是1的整数; R 1，R 2，R 3，R 4，R 5，和/或R 3中的每一个 >，并且R 6独立地是氢原子; A 1是咪唑; A 2是被烷基取代的咪唑或咪唑; W是苯基或萘基; X是CH 2 2; D是由-Q-Y-B表示的基团，其中Q是NR 12和R 12是氢原子或烷基; Y为（CH 2 2）m 3，m 3为2〜4的整数， 和B是N（R 25 R 26），其中R 25和R 26各自独立地是 氢原子，C 1 -C 6烷基或C 3 -C 6 -C 6环烷基。