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公开(公告)号:US06548674B2
公开(公告)日:2003-04-15
申请号:US09799607
申请日:2001-03-07
申请人: Miho Kawauchi , Noritsugu Yamasaki , Mitsuru Ohno
发明人: Miho Kawauchi , Noritsugu Yamasaki , Mitsuru Ohno
IPC分类号: C07D40508
CPC分类号: C07D319/06 , C07C235/80
摘要: A 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compounds can be produced by reacting a 6-halomethyl-4H-2,3-dioxin-4-one compound with a primary or secondary amine and carbon monoxide. The reaction may be carried out in the presence of a catalyst comprising a platinum group metal. 3-oxopentanedicarboxylic acid monoamides and 3-oxopentanedicarboxylic acid amide esters can be are produced by reacting 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compound with an alcohol or water. Using such intermediates, 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compound, 3-oxopentanedicarboxylic acid amide esters can provide in an easy and simple and efficient manner.
摘要翻译: 6-氨基羰基甲基-4H-2,3-二恶英-4-酮化合物可以通过使6-卤代甲基-4H-2,3-二恶英-4-酮化合物与伯胺或仲胺和一氧化碳反应来制备。 反应可以在包含铂族金属的催化剂的存在下进行。 3-氧代戊二酸单酰胺和3-氧代戊二酰胺酯可以通过6-氨基羰基甲基-4H-2,3-二恶英-4-酮化合物与醇或水反应来制备。 使用这种中间体,6-氨基羰基甲基-4H-2,3-二恶英-4-酮化合物,3-氧代戊二酰胺酯可以容易且简单和有效地提供。
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公开(公告)号:US06664258B1
公开(公告)日:2003-12-16
申请号:US09242819
申请日:1999-02-24
申请人: Anton F. J. Fliri , Todd W. Butler
发明人: Anton F. J. Fliri , Todd W. Butler
IPC分类号: C07D40508
CPC分类号: C07D295/073 , C07D295/112 , C07D295/155 , C07D307/94 , C07D333/50 , C07D333/58
摘要: This invention relates to novel, pharmaceutically active compounds of formula (I) wherein a, b and R1 through R6 are as defined in the specification These compounds exhibit central dopaminergic activity and are useful in the treatment of CNS disorders.
摘要翻译: 本发明涉及式(I)的新的药物活性化合物,其中a,b和R 1至R 6如说明书中所定义。这些化合物表现出中枢多巴胺能活性并且可用于治疗CNS疾病。
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公开(公告)号:US06677456B2
公开(公告)日:2004-01-13
申请号:US10091023
申请日:2002-03-06
申请人: Tsunehiko Soga , Kouichi Uoto , Yasuyuki Takeda
发明人: Tsunehiko Soga , Kouichi Uoto , Yasuyuki Takeda
IPC分类号: C07D40508
CPC分类号: C07D493/04 , A61K31/4355
摘要: This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered
摘要翻译: 本发明提供一种新颖的紫杉醇衍生物,其可用作具有各自取代基的抗肿瘤化合物,由下式(I)表示,其可以口服给药
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