摘要:
This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered
摘要:
A compound represented by the general formula (1) [X1 and X2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, R1 represents a phenyl group, R2 represents an alkyl group, an alkenyl group, or an alkoxy group, R3 represents hydrogen atom, a halogen atom, hydroxyl group, or an alkoxy group, R4 represents hydrogen atom, or an alkyl group, Z1 and Z2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, Z3 represents cyano group, an alkyl group, an alkenyl group and the like, Z4 represents an alkyl group, an alkenyl group, an alkynyl group and the like, and represents a single bond or a double bond], which shows high antitumor effect against cancer cells including drug resistant cells.
摘要:
The present invention provides a method for effectively producing an optically active form of tetrasubstituted-5-azaspiro[2.4]heptane derivative, which serves as a useful production intermediate for quinolonecarboxylic acid antibacterial agents, and intermediates for the derivative. The present invention is directed to a method for producing a compound (VII) according to the following scheme.
摘要:
To provide an image-recording medium, which can form a high quality image thereon without yellowing (the shift of color tone) or the blotting of the ink with both the dye ink and the pigment ink. An image-recording medium having a support having breathing micropores, the surfaces and the micropores of which are made hydrophilic, and an ink-receptive layer which is provided on the surface of the support and comprises a binder and a coagulant, characterized in that the ink-receptive layer contains a cationic organic oligomer having a cationic functional group in the molecule, or a cationic polymer having a cationic functional group in the molecule as a coagulant.
摘要:
Aminophenol derivatives represented by the following formula (1): ##STR1## wherein X is O or S; A is alkylene, R.sup.1 is phenyl, etc., R.sup.2 and R.sup.3 are H or alkyl; R.sup.4 is substituted carbamoylalkyl, etc.; R.sup.5 is substituted amino, etc.; their salts, and optical isomers of the derivatives and salts. Also disclosed are gastrin receptor antagonists, cholecystokinin receptor antagonists, and medicines for digestive diseases. The compounds have strong binding inhibition against gastrin receptor or CCK-A receptor and also they have higher selectivity to either group of CCK-A receptor or gastrin receptor, and therefore, the compounds are useful for preventing and treating gastrointestinal diseases including peptic ulcers as well as central nervous system diseases.
摘要:
A printed circuit board connector has: an insulating housing (2); SMT type contacts (7, 11) disposed in the insulating housing and spaced apart from each other; and each contact having a lead (11) which extends to a junction surface (2a) of the housing so as to be soldered to a conductive pattern (16) formed on a printed circuit board (15). The lead (11) of each contact is a plating layer (10) formed on the junction surface (2a). The contacts (7) are pin contacts held in place by the insulating housing (2) so as to be electrically connected to the plating layer (10) formed as the leads. The contacts' leads are included in a common plane so that the reliability of electric connection and the durability of connector are improved, and the connector is rendered thinner and more compact to reduce an area required to mount it.
摘要:
Disclosed is an epoxy resin composition which is solid at ordinary room temperature, cures with excellent light resistance and heat resistance and minimal shrinkage, and is useful for encapsulating LEDs. The epoxy resin composition is characterized by comprising as an essential component an epoxy resin having an epoxy equivalent of 300-1000 g/eq and a softening point of 65-110° C. obtained by reacting a nonaromatic polycarboxylic acid (A) having an acid value of 100-250 mgKOH/g with a nonaromatic epoxy resin (B) having an epoxy equivalent of 100-400 g/eq. The nonaromatic polycarboxylic acid (A) may be obtained by reacting 1,4-cyclohexanedimethanol, 2,2-bis(4-hydroxycyclohexyl)propane, or 3,9-bis(1,1-dimethyl-2-hydroxyethyl)-2,4,8,10-tetraoxaspiro[5,5]undecane with methylhexahydrophthalic acid or hexahydrophthalic acid.
摘要:
A vicinity search using register point data in a designated area reduces search time. The vicinity search data include at least category information, names of register points and country information. The search device conducts the vicinity search by specifying any one of category information to which the register points belong, names of the register points and country information, or a combination, by option and display. The search device further uses category information with flags representing the presence and absence of the register point data, whereby the register point data are searched by referring to the flags.
摘要:
The adhesive composition comprises a hydroxyl group-containing adhesive polymer having little or no carboxylic groups in the molecule, and a separate compound that is an aromatic carboxylic acid compound. This composition prevents the corrosion of a metal layer without requiring formation of a protective film in the production of an adhesive sheet comprising a metal layer.
摘要:
The developer solution of the invention is suitable for use to develop a positive-working resist composition comprising an alkali-soluble novolac resin and a naphthoquinone diazide compound and capable of giving a patterned image of the resist layer with a high contrast and increasing the effective depth of focus. The characteristic ingredient in the inventive developer solution is an alkali-soluble organic cyclic nitrogen compound such as N-hydroxyethyl piperazine, N-methyl-4-piperidone, 1,3-dimethyl-2-imidazolidinone and the like added in a specified concentration to a conventional developer solution containing tetramethyl ammonium hydroxide or choline as the water-soluble alkaline compound.