公开(公告)号：US3853847A

公开(公告)日：1974-12-10

申请号：US14327361

申请日：1961-10-02

申请人： US ARMY

发明人： LEE P ,  WRIGHT S ,  SIMS G

IPC分类号： C07D257/02 ,  C07D55/16 ,  C07D55/60

CPC分类号： C07D257/02

摘要： 1. A process for the purification of cyclotetramethylene tetranitramine which comprises heating a portion of crude cyclotetramethylene tetranitramine in the presence of linear nitramines in acetic acid, the acid concentration being at least 98 percent, to a temperature of from about 50 to 98*C., maintaining the resulting slurry for a period of about 15-45 minutes at said temperature from about 50 to 98*C., cooling the slurry to a temperature of about 30 to 40*C., adding to said slurry a new increment of said crude cyclotetramethylene tetranitramine, repeating the same cycle for a series of from 5 to 10 increment additions, and recovering a cyclotetramethylene tetranitramine product of high purity.

摘要翻译： 1.一种用于纯化四亚甲基四硝胺的方法，其包括在乙酸中存在线性硝胺的情况下加热一部分粗环己烷四亚甲基四硝胺，酸浓度至少为98％，温度为约50-98℃。 在约50至98℃的温度下将所得浆料保持约15-45分钟的时间，将浆料冷却至约30至40℃的温度，向所述浆料中加入所述浆料的新增量 粗环四亚甲基四硝胺，重复相同的循环进行5至10次增量添加，并回收高纯度的四环四亚甲基四硝胺。

公开(公告)号：US3673174A

公开(公告)日：1972-06-27

申请号：US3673174D

申请日：1970-07-30

申请人： US ARMY

发明人： SMITH CHARLES L ,  REYNOLDS WILLIAM S JR

IPC分类号： C06B21/00 ,  C07D55/16 ,  C07D55/60

CPC分类号： C06B21/0091

摘要： Process for the decontamination of reaction solutions which are contaminated with dissolved organic crystalline explosives, particularly those explosives commonly known as RDX and HMX. The process involves the selective adsorption of the dissolved explosives on activated carbon.

摘要翻译： 被溶解的有机结晶炸药污染的反应溶液去污的方法，特别是通常称为RDX和HMX的那些炸药。 该方法包括将溶解的炸药选择性吸附在活性炭上。

公开(公告)号：US20030119085A1

公开(公告)日：2003-06-26

申请号：US10280482

申请日：2002-10-24

申请人： The Regents of the University of California

发明人： Roger Y. Tsien ,  Gregor Zlokarnik

IPC分类号： C12Q001/18 ,  C07D55/16 ,  C07D51/14 ,  C07D487/04

CPC分类号： C07D501/36 ,  C07D501/00 ,  C07D505/00 ,  C07D519/00 ,  C12N9/86 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/002 ,  C12P17/184 ,  C12P17/188 ,  C12P35/00 ,  C12Q1/18 ,  C12Q1/34 ,  C12Q1/6897 ,  C12Q2334/00 ,  G01N2333/986 ,  G01N2415/00 ,  Y10S435/805

摘要： Substrates for null-lactamase of the general formula I 1 in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); Rnull is selected from the group consisting of H, lower (i.e., alkyl of 1 to about 5 carbon atoms) and (CH2)nOH, in which n is 0 or an integer from 1 to 5; Rnull is selected from the group consisting of H, physiologically acceptable metal and ammonium cations, nullCHR2OCO(CH2)nCH3, nullCHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, delta-butyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, acyloxyalkyl, dialkylaminocarbonyloxymethyl and aliphatic, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Znull and Znull are linkers for the fluorescent donor and quencher moieties. Methods of assaying null-lactamase activity and monitoring expression in systems using null-lactamase as a reporter gene also are disclosed.

摘要翻译： 通式I的β-内酰胺酶底物，其中X和Y中的一个是荧光供体部分，另一个是猝灭剂（其可以或不再发射）; R'选自H，低级（即1至约5个碳原子的烷基）和（CH 2）nOH，其中n为0或1至5的整数; R“选自H，生理学上可接受的金属和铵阳离子，-CHR2OCO（CH2）nCH3，-CHR2OCOC（CH3）3，酰基硫代甲基，酰氧基-α-苄基，δ-丁基内酰基，甲氧基羰氧基甲基，苯基，甲基亚磺酰基甲基 ，β-吗啉代乙基，二烷基氨基乙基，酰氧基烷基，二烷基氨基羰氧基甲基和脂族基，其中R2选自H和低级烷基; A选自S，O，SO，SO 2和CH 2; Z'和Z“是荧光供体和猝灭剂部分的接头。 公开了使用β-内酰胺酶作为报道基因的体内测定β-内酰胺酶活性和监​​测表达的方法。

公开(公告)号：US3676425A

公开(公告)日：1972-07-11

申请号：US3676425D

申请日：1970-10-06

申请人： US ARMY

发明人： DAWSON RALPH E ,  MAHAFFEY DONALD M

IPC分类号： C07D251/06 ,  C07D257/02 ,  C07D55/16 ,  C07D55/60

CPC分类号： C07D251/06 ,  C07D257/02

摘要： A process for the separation of HMX (cyclotetramethylenetetranitramine) from mixtures of RDX (cyclotrimethylenetrinitramine) and HMX whereby said mixtures are dissolved in hot, water-saturated cyclopentanone and the RDX and HMX are thereafter selectively precipitated.

摘要翻译： 从RDX（环三亚甲基硝胺）和HMX的混合物中分离出HMX（环四亚甲基四氮杂）的方法，由此将所述混合物溶解在热的水饱和环戊酮中，然后选择性地沉淀RDX和HMX。

公开(公告)号：US3637658A

公开(公告)日：1972-01-25

申请号：US3637658D

申请日：1968-11-26

申请人： US ARMY

发明人： WRIGHT SAM B ,  ROGERS JULIUS T

IPC分类号： C06B21/00 ,  C07D55/16 ,  C07D55/60

CPC分类号： C06B21/0091

摘要： RECOVERY OF HMX IN GOOD CONCENTRATIONS IS ACHIEVED FROM RDX-HMX ADMIXTURES BY PREFERENTIAL CRYSTAL GROWTH OF RDX IN SPENT ACID AND SUBSEQUENT SEPARATION OF THE FINE CRYSTALS OF HMX BY PHYSICAL METHODS. THE SPENT ACID WILL NORMALLY COMPRISE 60 TO 86, ACETIC ACID, 1 TO 2% NITRIC ACID, 1 TO 3% FORMIC ACID AND 1 TO 2% AMMONIUM NITRATE.