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公开(公告)号:US06639053B1
公开(公告)日:2003-10-28
申请号:US09720095
申请日:2001-12-21
IPC分类号: C07K1418
CPC分类号: C12N9/127 , C12Q1/707 , G01N33/5767
摘要: The present invention provides a gene encoding an RNA polymerase which plays an important role in the reproduction of hepatitis C virus, and a method of screening using this gene or this RNA polymerase protein, thereby allowing easy performance of screening for substances which inhibit the RNA polymerase playing an important role in HCV reproduction.
摘要翻译: 本发明提供编码在丙型肝炎病毒繁殖中起重要作用的RNA聚合酶的基因,以及使用该基因或该RNA聚合酶蛋白进行筛选的方法,从而容易地进行筛选抑制RNA聚合酶的物质 在HCV繁殖中起重要作用。
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公开(公告)号:US06673895B2
公开(公告)日:2004-01-06
申请号:US09881710
申请日:2001-06-18
IPC分类号: C07K1418
CPC分类号: C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2770/24122 , Y02A50/386 , Y02A50/394
摘要: The present invention relates to pro-apoptotic fragments of the Dengue virus pRM and E glycoproteins, methods of screening for molecules capable of inducing apoptosis and methods of inducing apoptosis in a cell.
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公开(公告)号:US06254873B1
公开(公告)日:2001-07-03
申请号:US08423338
申请日:1995-04-17
IPC分类号: C07K1418
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C12N2770/24134 , C12N2770/24161 , Y02A50/386
摘要: An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable cells, purified and inactivated under conditions which destroy infectivity but preserve immunogenicity, a high level of which is demonstrated in animal models.
摘要翻译: 描述了免疫和保护人类登革热的灭活登革病毒疫苗。 该疫苗是基于在合适的细胞中传播到高滴度的登革病毒,在破坏感染性但保持免疫原性的条件下纯化和灭活,在动物模型中证明了这一点。
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