STERILE LIPOSOME-CONTAINING COMPOSITIONS AND ARTICLES

    公开(公告)号:US20240360385A1

    公开(公告)日:2024-10-31

    申请号:US18687885

    申请日:2022-08-30

    申请人: LipoSphere Ltd.

    IPC分类号: C11D3/00 A61K9/127 A61P19/02

    摘要: Sterile compositions comprising an aqueous carrier and liposomes, wherein a mean diameter and/or zeta potential of the liposomes changes by no more than 20% over the course of 300 days, are described herein; as well as processes for preparing such compositions by subjecting an aqueous composition comprising the aqueous carrier and liposomes to a temperature of over 100° C. Further described are processes for preparing a sterile article of manufacture having lipids attached thereto, by contacting the article of manufacture with an aqueous composition comprising an aqueous carrier and liposomes, and subjecting it to a temperature of over 100° C.; as well as sterile articles of manufacture prepared according to a process described herein. The liposomes comprise a bilayer-forming lipid and a polymeric compound having the formula:




    wherein m, n, L, X, Y and Z are as defined herein.