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公开(公告)号：US06514754B1
公开(公告)日：2003-02-04
申请号：US09304110
申请日：1999-05-04
IPC分类号： C12N1538
CPC分类号： C12N15/86 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/255 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N9/0093 , C12N9/1211 , C12N15/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TE (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
摘要翻译： 火鸡疱疹病毒（HVT），马立克氏病病毒（MDV）和感染性喉气管炎病毒（ILTV）的各种基因已被鉴定为非必需区域（以及外来基因插入位点的候选物）和/或作为抗原编码区域 。 前者包括HSV（单纯疱疹病毒）gC基因的HVT同源物，MDV或ILTV的TE（胸苷激酶）区，ILTV的ORF3（如本文所定义），ILTV的核糖核苷酸还原酶（大亚单位）基因，MDV 或HVT和MDV的核糖核苷酸还原酶（小亚基）基因。 抗原编码区包括HSV gB，gC和gH基因的HVT同源物，HSV gB的ILTV同源物，ILTV的ORF2和HSV-1即时早期基因IE-175和IE-68的HVT同源物。 这些基因的操作允许制备包含减毒病毒或携带异源抗原编码序列的病毒的疫苗。
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2.发明授权Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof 失效人巨细胞病毒（HCMV）的结构磷蛋白（pp28），其制备及应用公开(公告)号：US06733989B1
公开(公告)日：2004-05-11
申请号：US08460715
申请日：1995-06-02
申请人： Michael Mach , Heidi Meyer , Michael Bröker , Leander Lauffer
发明人： Michael Mach , Heidi Meyer , Michael Bröker , Leander Lauffer
IPC分类号： C12N1538
CPC分类号： C12Q1/705 , A61K39/00 , C07K14/005 , C12N2710/16122
摘要： Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof Expression of an SmaI fragment, which is about 1.0 kb in size, on the left-hand end of the HindIII R fragment makes it possible to synthesize, by genetic manipulation, a structural phosphoprotein of HCMV. This phosphoprotein, or immunogenic parts thereof, can be used as diagnostic aid or vaccine.
摘要翻译： 人巨细胞病毒（HCMV）的结构磷蛋白（pp28），其制备及其用途在HindIII R片段左端的表达大小约为1.0kb的SmaI片段使得可以通过遗传操作 ，HCMV的结构磷蛋白。 该磷蛋白或其免疫原性部分可用作诊断辅助剂或疫苗。
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公开(公告)号：US06316252B1
公开(公告)日：2001-11-13
申请号：US09213343
申请日：1998-12-17
申请人： Jerome S. Harms , Gary A. Splitter
发明人： Jerome S. Harms , Gary A. Splitter
IPC分类号： C12N1538
CPC分类号： C07K14/005 , C07K2319/00 , C12N15/87 , C12N2710/16722 , Y10S530/826
摘要： Disclosed herein are fusion proteins, nucleotide sequences for creating them, and vectors containing the nucleotide sequences. The fusion proteins have a bovine herpesvirus protein linked to a biotherapeutic protein or reporter protein. They rapidly spread biotherapeutic or reporter protein throughout mammalian cells.
摘要翻译： 本文公开了融合蛋白，用于产生它们的核苷酸序列和含有核苷酸序列的载体。 融合蛋白具有与生物治疗性蛋白质或报道蛋白连接的牛疱疹病毒蛋白。 他们在整个哺乳动物细胞中快速传播生物治疗或报告蛋白。
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公开(公告)号：US06251634B1
公开(公告)日：2001-06-26
申请号：US08485290
申请日：1995-06-07
IPC分类号： C12N1538
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16722 , G01N33/56983
摘要： The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
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