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公开(公告)号：US5965435A
公开(公告)日：1999-10-12
申请号：US460257
申请日：1995-06-02
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/215 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/275 , A61K39/295 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/20 , A61P31/22 , A61P37/04 , C07K14/03 , C07K14/035 , C07K14/055 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/38 , C12N15/45 , C12N15/869 , C12P21/02 , C12R1/91 , C12R1/92 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
摘要翻译： 火鸡疱疹病毒（HVT），马立克氏病病毒（MDV）和感染性喉气管炎病毒（ILTV）的各种基因已被鉴定为非必需区域（以及外来基因插入位点的候选物）和/或作为抗原编码区域 。 前者包括HSV（单纯疱疹病毒）gC基因的HVT同源物，MDV或ILTV的TK（胸苷激酶）区，ILTV的ORF3（如本文所定义），ILTV的核糖核苷酸还原酶（大亚基）基因，MDV 或HVT和MDV的核糖核苷酸还原酶（小亚基）基因。 抗原编码区包括HSV gB，gC和gH基因的HVT同源物，HSV gB的ILTV同源物，ILTV的ORF2和HSV-1即时早期基因IE-175和IE-68的HVT同源物。 这些基因的操作允许制备包含减毒病毒或携带异源抗原编码序列的病毒的疫苗。
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公开(公告)号：US6100088A
公开(公告)日：2000-08-08
申请号：US223001
申请日：1998-12-30
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/215 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/275 , A61K39/295 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/20 , A61P31/22 , A61P37/04 , C07K14/00 , C07K14/005 , C07K14/03 , C07K14/035 , C07K14/055 , C07K14/195 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/33 , C12N15/38 , C12N15/45 , C12N15/86 , C12N15/869 , C12P21/02 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
摘要翻译： 对马立克氏病病毒（MDV）有效的疫苗包括（a）通过TK-或（b）表达MDV抗原的宿主减毒的MDV，即HSV gB，gC，gD或gH糖蛋白的相应MDV同源物 （或其抗原部分）或HSV-1即时早期基因IE-68或IE-175的相应MDV同源物。 宿主可能是疱疹病毒（HVT），特别是其中MDV抗原插入HSV gC基因的HVT同源物，核糖核苷酸还原酶（大亚基）基因或胸苷激酶（TK））基因的HVT。
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公开(公告)号：US5840574A
公开(公告)日：1998-11-24
申请号：US462591
申请日：1995-06-05
IPC分类号： A61K38/00 , A61K39/00 , A61K39/245 , A61K39/255 , C07K14/03 , C07K14/055 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/38 , C12N15/869 , C12N15/85
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343 , C12N2710/16722 , C12N2710/16734
摘要： A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
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公开(公告)号：US5958425A
公开(公告)日：1999-09-28
申请号：US938336
申请日：1997-09-25
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/215 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/275 , A61K39/295 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/20 , A61P31/22 , A61P37/04 , C07K14/00 , C07K14/005 , C07K14/03 , C07K14/035 , C07K14/055 , C07K14/195 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/33 , C12N15/38 , C12N15/45 , C12N15/86 , C12N15/869 , C12P21/02 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
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公开(公告)号：US06514754B1
公开(公告)日：2003-02-04
申请号：US09304110
申请日：1999-05-04
IPC分类号： C12N1538
CPC分类号： C12N15/86 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/255 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N9/0093 , C12N9/1211 , C12N15/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TE (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
摘要翻译： 火鸡疱疹病毒（HVT），马立克氏病病毒（MDV）和感染性喉气管炎病毒（ILTV）的各种基因已被鉴定为非必需区域（以及外来基因插入位点的候选物）和/或作为抗原编码区域 。 前者包括HSV（单纯疱疹病毒）gC基因的HVT同源物，MDV或ILTV的TE（胸苷激酶）区，ILTV的ORF3（如本文所定义），ILTV的核糖核苷酸还原酶（大亚单位）基因，MDV 或HVT和MDV的核糖核苷酸还原酶（小亚基）基因。 抗原编码区包括HSV gB，gC和gH基因的HVT同源物，HSV gB的ILTV同源物，ILTV的ORF2和HSV-1即时早期基因IE-175和IE-68的HVT同源物。 这些基因的操作允许制备包含减毒病毒或携带异源抗原编码序列的病毒的疫苗。
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公开(公告)号：US06413762B2
公开(公告)日：2002-07-02
申请号：US09745810
申请日：2000-12-26
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/255 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N9/0093 , C12N9/1211 , C12N15/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： Various genes of herpes virus of turkeys (HVT) Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
摘要翻译： 火鸡疱疹病毒（HVT）马立克病病毒（MDV）和感染性喉气管炎病毒（ILTV）的各种基因已被鉴定为非必需区域（以及外源基因插入位点的候选者）和/或作为抗原编码区域。 前者包括HSV（单纯疱疹病毒）gC基因的HVT同源物，MDV或ILTV的TK（胸苷激酶）区，ILTV的ORF3（如本文所定义），ILTV的核糖核苷酸还原酶（大亚基）基因，MDV 或HVT和MDV的核糖核苷酸还原酶（小亚基）基因。 抗原编码区包括HSV gB，gC和gH基因的HVT同源物，HSV gB的ILTV同源物，ILTV的ORF2和HSV-1即时早期基因IE-175和IE-68的HVT同源物。 这些基因的操作允许制备包含减毒病毒或携带异源抗原编码序列的病毒的疫苗。
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公开(公告)号：US5906821A
公开(公告)日：1999-05-25
申请号：US125039
申请日：1993-09-22
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/215 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/275 , A61K39/295 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/20 , A61P31/22 , A61P37/04 , C07K14/03 , C07K14/035 , C07K14/055 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/38 , C12N15/45 , C12N15/869 , C12P21/02 , C12R1/91 , C12R1/92 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
摘要翻译： 火鸡疱疹病毒（HVT），马立克氏病病毒（MDV）和感染性喉气管炎（ILTV）的各种基因已被确定为非必需区域（以及外来基因插入位点的候选物）和/或作为抗原编码区域。 前者包括HSV（单纯疱疹病毒）gC基因的HVT同源物，MDV或ILTV的TK（胸苷激酶）区，ILTV的ORF3（如本文所定义），ILTV的核糖核苷酸还原酶（大亚基）基因，MDV 或HVT和MDV的核糖核苷酸还原酶（小亚基）基因。 抗原编码区包括HSV gB，gC和gH基因的HVT同源物，HSV gB的ILTV同源物，ILTV的ORF2和HSV-1即时早期基因IE-175和IE-68的HVT同源物。 这些基因的操作允许制备包含减毒病毒或携带异源抗原编码序列的病毒的疫苗。
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公开(公告)号：US5744143A
公开(公告)日：1998-04-28
申请号：US654931
申请日：1996-05-29
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/215 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/275 , A61K39/295 , A61K48/00 , A61P31/00 , A61P31/12 , A61P31/20 , A61P31/22 , A61P37/04 , C07K14/00 , C07K14/005 , C07K14/03 , C07K14/035 , C07K14/055 , C07K14/195 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N9/02 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/33 , C12N15/38 , C12N15/45 , C12N15/86 , C12N15/869 , C12P21/02 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/255 , C07K14/005 , C12N15/00 , C12N9/0093 , C12N9/1211 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K38/00 , A61K39/00 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
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