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    Marek's disease virus vaccine
    3.
    发明授权
    Marek's disease virus vaccine 失效
    马立克氏病病毒疫苗

    公开(公告)号：US07214524B1

    公开(公告)日：2007-05-08

    申请号：US10430773

    申请日：2003-05-06

    申请人： Sanjay M. Reddy ,  Blanca M. Lupiani

    发明人： Sanjay M. Reddy ,  Blanca M. Lupiani

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/255 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N2710/16334 ,  C12N2710/16361

    摘要： An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.

    摘要翻译： 马立克氏病的有效疫苗可以使用不能表达功能性meq蛋白的马立克氏病病毒的病毒剂来制备。 这种病毒剂有效地引起鸡中非常毒性的马立克氏病病毒株的免疫应答，而不会在接种的鸟中引起显着程度的致病性。 用于鸡的合适的疫苗制剂包括具有药学上可接受的载体或稀释剂的该新型病毒剂的有效免疫剂量。

    Marek's disease virus vaccine
    4.
    发明申请
    Marek's disease virus vaccine 审中-公开
    马立克氏病病毒疫苗

    公开(公告)号：US20050019348A1

    公开(公告)日：2005-01-27

    申请号：US10623891

    申请日：2003-07-21

    申请人： Sanjay Reddy ,  Blanca Lupiani ,  Richard Witter

    发明人： Sanjay Reddy ,  Blanca Lupiani ,  Richard Witter

    IPC分类号： A61K39/255 ,  C12N7/01 ,  C12Q1/70 ,  A61K39/12 ,  A61K39/245 ,  C07H21/04

    CPC分类号： A61K39/255 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2740/13022 ,  C12N2820/60 ,  C12N2830/60

    摘要： An effective vaccine for Marek's disease may be prepared using a recombinant Marek's disease virus CVI988 transformed with a foreign DNA construct which includes a long terminal repeat sequence of a reticuloendotheliosis virus. This viral agent is effective to elicit an immune response in a chicken to Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.

    摘要翻译： 可以使用包含网状内皮组织增生病毒的长末端重复序列的外源DNA构建体转化的重组马立克氏病病毒CVI988来制备马立克氏病的有效疫苗。 该病毒剂能有效地引起鸡中马立克氏病病毒的免疫反应，而不会在接种的鸟类中引起显着程度的致病性。 用于鸡的合适的疫苗制剂包括具有药学上可接受的载体或稀释剂的该新型病毒剂的有效免疫剂量。

    Processes for preparation of marek's disease virus using continuous avian cell lines
    6.
    发明申请
    Processes for preparation of marek's disease virus using continuous avian cell lines 审中-公开
    使用连续禽类细胞系制备马立克氏病病毒的方法

    公开(公告)号：US20020132337A1

    公开(公告)日：2002-09-19

    申请号：US10134241

    申请日：2002-04-29

    发明人： Sing Rong ,  Michael G. Sheppard

    IPC分类号： A61K039/12 ,  C12N007/00 ,  C12N005/06

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/255 ,  A61K2039/525 ,  C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2710/16361

    摘要： An amplifier distortion reduction system obtains a distortion signal from the amplifier output and feeds the distortion signal back to the input side of the amplifier to cancel with the distortion produced at the amplifier output. For example, a signal to be amplified by an amplifier is received on a main signal path. The amplifier produces an amplified output with a non-distortion spectrum and a distortion spectrum. A sample of the amplified output is produced from the main signal path and placed on a feedback path. On the feedback path, the distortion spectrum is obtained from the sample amplified output. The distortion spectrum is phase and/or amplitude adjusted to produce the distortion signal. The distortion signal is placed onto the main signal path at the input side of the amplifier with the signal to be amplified to destructively combine with the distortion produced from the amplifier in amplifying the signal to be amplified.

    摘要翻译： 放大器失真减小系统从放大器输出端获得失真信号，并将失真信号反馈到放大器的输入侧，以消除放大器输出端产生的失真。 例如，在主信号路径上接收由放大器放大的信号。 放大器产生具有非失真频谱和失真频谱的放大输出。 放大输出的样本从主信号路径产生并放置在反馈路径上。 在反馈路径上，从样本放大输出获得失真谱。 失真频谱是相位和/或幅度调整以产生失真信号。 失真信号被放置在放大器的输入侧的主信号路径上，其中要放大的信号与在放大信号放大时产生的失真相结合。

    In ovo vaccination of marek's disease type I virus
    7.
    发明授权
    In ovo vaccination of marek's disease type I virus 失效
    在ovo接种马立克氏病I型病毒

    公开(公告)号：US06410222B1

    公开(公告)日：2002-06-25

    申请号：US09622093

    申请日：2000-08-11

    申请人： Kenji Yokogawa ,  Masashi Sakaguchi ,  Eiji Tokunaga

    发明人： Kenji Yokogawa ,  Masashi Sakaguchi ,  Eiji Tokunaga

    IPC分类号： C12Q170

    CPC分类号： A61K39/255 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2760/18134

    摘要： The preset invention provides a method for immunizing chickens which comprises inoculating into growing egg a composition comprising either cell-free attenuated viruses of Marek's disease type 1 or cells infected with attenuated viruses of Marek's disease type 1 capable of producing cell-free viruses. The present invention also provides a method for immunizing chickens which comprises inoculating into growing egg a mixed vaccine comprising said composition plus another vaccine from at least one microorganisms selected from the group consisting of viruses other than virus of Marek's disease type 1, bacteria and protozoan.

    摘要翻译： 本发明提供了一种用于免疫鸡的方法，其包括将生长的卵中的一种组合物接种到生长中的鸡中，所述组合物包含1型马立克氏病的无细胞减毒病毒或能够产生无细胞病毒的1型马立克氏病减毒病毒感染的细胞。 本发明还提供了一种免疫鸡的方法，其包括将包含所述组合物的混合疫苗和来自至少一种选自除了马立克氏病1型病毒以外的病毒的细菌和细菌和原生动物的至少一种微生物接种到生长的鸡蛋中。