公开(公告)号：US20190216920A1

公开(公告)日：2019-07-18

申请号：US16262774

申请日：2019-01-30

Applicant: Boehringer Ingelheim Aminal Health USA Inc.

Inventor： Joyce Pritchard ,  Teshome Mebatsion ,  Michel Bublot

IPC: A61K39/255 ,  A61K39/12

CPC classification number: A61K39/255 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N2710/16334 ,  C12N2740/13022 ,  C12N2830/60

Abstract: The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.

公开(公告)号：US20170298386A9

公开(公告)日：2017-10-19

申请号：US14551487

申请日：2014-11-24

Applicant: BIOMUNE COMPANY

Inventor： Motoyuki ESAKI ,  Lauren Elizabeth Jensen ,  Kristi M. Dorsey

IPC: C12N15/86 ,  C12N7/00 ,  C12N15/85 ,  C12N15/63 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C07K14/11 ,  C12N15/869 ,  A61K39/00

CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/11 ,  C12N7/00 ,  C12N15/63 ,  C12N15/85 ,  C12N15/869 ,  C12N2710/16143 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16443 ,  C12N2760/16134 ,  C12N2830/34 ,  C12N2830/60

Abstract: The present invention provides a recombinant turkey herpesvirus modified by the presence of the cDNA encoding the hemagglutinin protein of avian influenza virus under a promoter. A poultry vaccine comprising the recombinant turkey herpesvirus described in the present invention can induce serological responses that may be easily detected by the hemagglutination inhibition assay but not by commercially available diagnostic ELISA kits; thus enabling easy differentiation between vaccination and field infection.

公开(公告)号：US20170095516A1

公开(公告)日：2017-04-06

申请号：US15108047

申请日：2015-06-24

Applicant: Biogaia AB

Inventor： Uma Nathan ,  Bo Möllstam

IPC: A61K35/747 ,  C12N7/00 ,  A61K39/255

CPC classification number: A61K35/747 ,  A01K45/007 ,  A23K10/16 ,  A23K10/18 ,  A23K50/75 ,  A61K39/12 ,  A61K39/255 ,  A61K2039/54 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/16334 ,  C12N2760/18134

Abstract: The present invention generally relates to a strain of Lactobacillus probiotic bacteria and a poultry vaccine for use in the in ovo vaccination of poultry, wherein said strain and said vaccine are administered to an embryonated poultry egg. Compositions suitable for use in an in ovo vaccination protocol for poultry comprising a strain of Lactobacillus probiotic bacteria and a vaccine diluent which is suitable for the poultry vaccine to be used in said vaccination protocol are also provided, as are suitable kits for use in the invention.

公开(公告)号：US20170043006A1

公开(公告)日：2017-02-16

申请号：US15228912

申请日：2016-08-04

Applicant: The Texas A&M University System

Inventor： Sanjay M. Reddy ,  Blanca M. Lupiani

IPC: A61K39/12 ,  A61K39/255 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  A61P31/12 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16371 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10071

Abstract: The present disclosure provides a recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome for treatment of diseases in poultry. Also provided are immunogenic compositions comprising such recombinant viral vectors and methods for preventing or inhibiting Marek's disease in combination with at least a second disease in poultry.

Abstract translation: 本公开提供了包含插入马立克氏病病毒基因组中的至少一种转基因用于治疗家禽疾病的重组病毒载体。 还提供了包含这种重组病毒载体的免疫原性组合物和用于预防或抑制马立克氏病与家禽中至少第二种疾病相结合的方法。

公开(公告)号：US20150376569A1

公开(公告)日：2015-12-31

申请号：US14845992

申请日：2015-09-04

Applicant: BIOMUNE COMPANY

Inventor： SHARAD DEVIDASRAO SAWARKAR ,  CHRISTOPHER PATRICK GULLY

IPC: C12N5/073 ,  A61K39/255 ,  C12N7/00

CPC classification number: C12N5/0604 ,  A61K39/255 ,  C12N7/00 ,  C12N2511/00 ,  C12N2710/16334 ,  C12N2710/16352 ,  C12N2710/16361 ,  C12N2720/12052

Abstract: The present invention relates to compositions and methods for preparing cells from avian embryos. The invention also relates to cultures of such cells and the uses thereof, particularly for producing viruses such as MDV. The invention also relates to methods for the preparation of vaccines using such cells or viruses.

Abstract translation: 本发明涉及从禽类胚胎制备细胞的组合物和方法。 本发明还涉及这种细胞的培养物及其用途，特别是用于产生病毒如MDV。 本发明还涉及使用这种细胞或病毒制备疫苗的方法。

公开(公告)号：US20150344528A1

公开(公告)日：2015-12-03

申请号：US14533666

申请日：2014-11-05

Applicant: INTERVET INC.

Inventor： Stephanie Cook ,  Mohamad Morsey ,  Gary Petersen ,  Paulus Jacobus Antonius Sondermeijer

IPC: C07K14/005 ,  C12N7/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10011 ,  C12N2720/10034 ,  C12N2760/18011 ,  C12N2760/18034 ,  C12N2760/18111 ,  C12N2760/18134

Abstract: The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of their use in poultry vaccines.

Abstract translation: 本发明公开了编码和表达传染性喉气管炎病毒和新城疫病毒蛋白抗原的新型重组多价非致病性马立克氏病病毒构建体及其在家禽疫苗中的应用。

公开(公告)号：US08932604B2

公开(公告)日：2015-01-13

申请号：US13655858

申请日：2012-10-19

Applicant: Intervet Inc.

Inventor： Stephanie Cook ,  Mohamad Morsey ,  Gary Petersen ,  Paulus Jacobus Antonius Sondermeijer

IPC: C12Q1/70 ,  A61K39/245 ,  C12N15/86 ,  C12N7/01 ,  A61P31/14 ,  A61P37/04 ,  A61P31/22 ,  C12N15/62 ,  A61K39/295

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10011 ,  C12N2720/10034 ,  C12N2760/18011 ,  C12N2760/18034 ,  C12N2760/18111 ,  C12N2760/18134

Abstract: Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of their use in poultry vaccines.

Abstract translation: 编码和表达传染性喉气管炎病毒和新城疫病毒蛋白抗原的重组多价非致病性马立克氏病病毒构建体及其在家禽疫苗中的应用方法。

公开(公告)号：US07569365B2

公开(公告)日：2009-08-04

申请号：US12076490

申请日：2008-03-19

Applicant: Takanori Sato

Inventor： Takanori Sato

IPC: C12P19/34

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2720/10022 ,  C12N2760/18122 ,  C12N2830/205

Abstract: Promoter genes that are derived from Marek's disease virus (MDV). These promoter genes can express two foreign genes when inserted in a recombinant turkey herpesvirus (HVT). A recombinant HVT having said novel promoter gene between two foreign genes. The poultry vaccine consisting of the recombinant turkey herpesvirus described in the present invention.

Abstract translation: 来自马立克氏病病毒（MDV）的启动子基因。 当插入重组火鸡疱疹病毒（HVT）时，这些启动子基因可以表达两种外源基因。 具有两个外源基因之间的新启动子基因的重组HVT。 由本发明描述的重组火鸡疱疹病毒组成的家禽疫苗。

公开(公告)号：US20080260777A1

公开(公告)日：2008-10-23

申请号：US11737483

申请日：2007-04-19

Applicant: Konky SOTOMAYOR

Inventor： Konky SOTOMAYOR

IPC: A61K39/116 ,  A61K39/295 ,  A61P31/00

CPC classification number: A61K39/0258 ,  A61K39/0208 ,  A61K39/0275 ,  A61K39/08 ,  A61K39/104 ,  A61K39/12 ,  A61K39/255 ,  A61K2039/521 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16334 ,  Y02A50/474 ,  Y02A50/482

Abstract: An antigen composition for stimulating an immune response in an inoculated avian species to at least one intestinal pathogenic organism includes seven field strains of E. coli, Pseudomona aeruginosa, Aerobacter aerogenes, Salmonella enteritidis, Salmonella typhimurium, Salmonella agona, and Salmonella Kentucky. The antigen, composition can be used alone or in combination with a Marek's Disease vaccine to reduce shedding of E. coli and/or Salmonella bacteria.

Abstract translation: 用于刺激接种的禽类物种对至少一种肠道致病生物体的免疫应答的抗原组合物包括大肠杆菌，铜绿假单胞菌，产气杆菌，肠炎沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌和肯塔基沙门氏菌的七种野生型菌株。 抗原组合物可单独使用或与马立克氏病疫苗组合使用，以减少大肠杆菌和/或沙门氏菌细菌的脱落。

公开(公告)号：US20080118468A1

公开(公告)日：2008-05-22

申请号：US11661689

申请日：2004-09-03

Applicant: Alexander Sulakvelidze ,  Shanmuga Sozhamamnnan ,  Gary R. Pasternack

Inventor： Alexander Sulakvelidze ,  Shanmuga Sozhamamnnan ,  Gary R. Pasternack

IPC: A61K35/76 ,  C12N7/00 ,  C12N15/11 ,  A61P43/00 ,  C12Q1/70

CPC classification number: A61K39/12 ,  A61K39/0275 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16334 ,  Y02A50/482

Abstract: The present invention is directed to isolated Salmonella bacteriophage, and methods of using Salmonella bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Salmonella. The present invention also contemplates the use of Salmonella bacteriophage, and polynucleotides and polypeptides derived therefrom, for the treatment of host infections or environmental contamination by Salmonella.

Abstract translation: 本发明涉及分离的沙门氏菌噬菌体，以及使用沙门氏菌噬菌体或由其衍生的多核苷酸和多肽来控制沙门氏菌食物生长或污染的方法。 本发明还考虑了沙门氏菌噬菌体及其衍生的多核苷酸和多肽用于治疗宿主感染或沙门氏菌的环境污染。