公开(公告)号：US20240361407A1

公开(公告)日：2024-10-31

申请号：US18764964

申请日：2024-07-05

申请人： NVISION IMAGING TECHNOLOGIES GMBH

发明人： Ilai SCHWARTZ ,  Anna PARKER ,  Stephan KNECHT ,  Tim EICHHORN ,  John BLANCHARD

IPC分类号： G01R33/36 ,  A61K49/10 ,  B01D11/04

CPC分类号： G01R33/3628 ,  A61K49/10 ,  B01D11/04

摘要： Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

公开(公告)号：US20240350678A1

公开(公告)日：2024-10-24

申请号：US18687044

申请日：2022-08-26

申请人： NVISION IMAGING TECHNOLOGIES GMBH

发明人： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT

IPC分类号： A61K49/10 ,  C07B59/00

CPC分类号： A61K49/10 ,  C07B59/001 ,  C07B2200/05

摘要： The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

公开(公告)号：US20240251658A1

公开(公告)日：2024-07-25

申请号：US18287129

申请日：2021-12-01

申请人： BeeOLED GmbH

发明人： Carsten ROTHE ,  Volodymyr SENKOVSKYY

IPC分类号： H10K85/30 ,  A61B5/055 ,  A61K49/10 ,  C07F5/00 ,  C09K11/02 ,  C09K11/06 ,  G01R33/56 ,  H10K50/11 ,  H10K71/10 ,  H10K71/16 ,  H10K85/10

CPC分类号： H10K85/351 ,  A61K49/101 ,  C07F5/003 ,  C09K11/02 ,  C09K11/06 ,  H10K71/16 ,  H10K71/191 ,  H10K85/10 ,  A61B5/055 ,  C09K2211/1007 ,  C09K2211/1044 ,  C09K2211/1074 ,  C09K2211/1096 ,  C09K2211/182 ,  G01R33/5601 ,  H10K50/11

摘要： A metal-organic coordination compound, which is neutrally charged and wherein the coordination compound comprises at least one divalent lanthanide coordinated by a cyclic organic ligand, wherein the cyclic organic ligand contains two monoanionic groups covalently linked with the cyclic organic ligand and being separated from each other by a sequence of at least two intervening atoms.

公开(公告)号：US20240225448A1

公开(公告)日：2024-07-11

申请号：US18559323

申请日：2022-04-28

申请人： Bayer Aktiengesellschaft

发明人： Gunnar SCHUETZ ,  Gesine KNOBLOCH

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61K49/10 ,  G01R33/56

CPC分类号： A61B5/004 ,  A61B5/055 ,  A61B5/4244 ,  A61K49/103 ,  G01R33/5601 ,  G01R33/5608

摘要： The invention relates to the technical field of characterising lesions in the liver using dynamic contrast-enhanced magnetic resonance tomography.

公开(公告)号：US20240199588A1

公开(公告)日：2024-06-20

申请号：US18550178

申请日：2022-03-21

申请人： The Hong Kong Polytechnic University

发明人： Ga-Lai LAW

IPC分类号： C07D403/14 ,  A61K49/00 ,  A61K49/10 ,  A61K51/04 ,  C07D255/02 ,  C07D401/14

CPC分类号： C07D403/14 ,  A61K49/0002 ,  A61K49/106 ,  A61K51/0482 ,  C07D255/02 ,  C07D401/14

摘要： Cyclic 1,4,7-triazacyclononane-1,4,7-triacetic acid chelators and metal complexes comprising the same useful as positron emission tomography imaging agents, magnetic resonance imaging contrast agents, and computed tomography imaging agents, and optical imaging agents, and methods of use and preparation thereof.

公开(公告)号：US11931428B2

公开(公告)日：2024-03-19

申请号：US16947869

申请日：2020-08-21

申请人： Wake Forest University Health Sciences

发明人： John C. Lukesh, III

IPC分类号： C07F11/00 ,  A61K9/00 ,  A61K49/00 ,  A61K49/10

CPC分类号： A61K49/0039 ,  A61K9/0019 ,  A61K9/0053 ,  C07F11/00

摘要： Provided herein is a compound of formula I:




and the use thereof for detecting the presence of hydrogen sulfide in cells or tissues in vitro or in vivo. The detecting may be useful, for example, in diagnosing cancer or other diseases related to imbalanced hydrogen sulfide (H2S) production such as neurodegenerative diseases.

公开(公告)号：US20230414791A1

公开(公告)日：2023-12-28

申请号：US18463450

申请日：2023-09-08

申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED

发明人： Ayelet GAMLIEL ,  Talia HARRIS ,  Gal SAPIR ,  Jacob SOSNA ,  Moshe John GOMORI ,  Rachel KATZ-BRULL

IPC分类号： A61K49/10 ,  A61B5/055 ,  G01R33/56 ,  G01R33/563

CPC分类号： A61K49/10 ,  A61B5/055 ,  G01R33/5601 ,  G01R33/56366

摘要： The present application provides a compound comprising at least one isotopically labeled nitrogen atom for use in diagnosing a condition or disease in a subject, compositions and kits comprising the compound and methods of using the same.

公开(公告)号：US20230405153A1

公开(公告)日：2023-12-21

申请号：US18336708

申请日：2023-06-16

申请人： Purdue Research Foundation

发明人： Philip Stewart Low ,  Ramesh Mukkamala ,  Madduri Srinivasarao

IPC分类号： A61K49/08 ,  A61K49/10

CPC分类号： A61K49/085 ,  A61K49/108

摘要： A conjugate comprising FL-L-IA, wherein FL is a radical of a small molecule ligand that specifically binds with fibroblast activation protein (FAP), L is a linker, which binds an FL to IA, and IA is a radical of a magnetic resonance imaging (MRI) agent, or a pharmaceutically acceptable salt thereof; a composition comprising same; and a method of using the conjugate or composition to image cells, a tissue, or an organ that express(es) FAP with magnetic resonance imaging.

公开(公告)号：US20230398238A1

公开(公告)日：2023-12-14

申请号：US18455407

申请日：2023-08-24

申请人： Texas Children's Hospital ,  Alzeca Biosciences, LLC

发明人： Eric A. Tanifum ,  Xianwei Sun ,  Ananth V. Annapragada ,  Carlo Medici

IPC分类号： A61K49/08 ,  C07C49/755 ,  C07C65/40 ,  C07D333/22 ,  A61K49/18 ,  A61K47/54 ,  A61K9/127 ,  A61K49/10

CPC分类号： A61K49/085 ,  C07C49/755 ,  C07C65/40 ,  C07D333/22 ,  A61K49/1812 ,  A61K47/542 ,  A61K47/545 ,  A61K9/1271 ,  A61K49/108 ,  A61K47/544

摘要： A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I:




wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or




A and B are independently selected from C and N; R1, R2, R3, and R4 are independently selected from —H, halogen, —OH, and —CH3; and R5, R6, and R7 are independently selected from —H, halogen, —OH, —OCH3, —NO2, —N(CH3)2, C1-C6 alkyl, or a substituted or unsubstituted C4-C6 aryl group, except that when A and/or B is N the adjacent R5 and/or R7 is —H, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230355810A1

公开(公告)日：2023-11-09

申请号：US18310588

申请日：2023-05-02

申请人： B. Braun Melsungen AG

发明人： Thorsten Keller ,  Doris Rothlein ,  Jurgen Schmitt ,  Thore Dietrich ,  Philipp Stawowy ,  Eckart Fleck

IPC分类号： A61K49/18 ,  A61K49/10 ,  A61B5/055 ,  G01R33/56

CPC分类号： A61K49/1806 ,  A61K49/10 ,  A61B5/055 ,  G01R33/5601

摘要： The present invention relates to an aqueous emulsion comprising



a) a semifluorinated compound of formula I:






CF3—(CF2)x—(CH2)y—CH3   (I)



 wherein x is an integer ranging from 1 to 8 and y is an integer ranging from 2 to 10,
b) a triglyceride which is miscible with the semifluorinated compound at 20° C.; and
c) an emulsifier.