公开(公告)号：US20230036800A1

公开(公告)日：2023-02-02

申请号：US17818585

申请日：2022-08-09

申请人： Covidien LP

发明人： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC分类号： A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06

摘要： Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US11511020B2

公开(公告)日：2022-11-29

申请号：US17099420

申请日：2020-11-16

申请人： Timothy J. Ryan

发明人： Timothy J. Ryan

IPC分类号： A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61L33/00 ,  A61M1/36 ,  A61L27/34 ,  A61N1/20 ,  A61L29/14 ,  A61F2/24 ,  A61L27/50 ,  A61L29/08 ,  A61F2/89

摘要： A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.

公开(公告)号：US11484630B2

公开(公告)日：2022-11-01

申请号：US15954943

申请日：2018-04-17

申请人： Colorado State University Research Foundation

发明人： Arun Kumar Kota ,  Ketul Popat ,  Sanli Movafaghi ,  Victoria Leszczak Murphy ,  Wei Wang

IPC分类号： A61L33/00 ,  C01G23/08 ,  A61L33/04 ,  A61L27/50 ,  A61L33/02 ,  A61L27/06 ,  C01G23/053

摘要： In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.

公开(公告)号：US11471567B2

公开(公告)日：2022-10-18

申请号：US16529973

申请日：2019-08-02

申请人： VeriGraft AB

发明人： Raimund Strehl

IPC分类号： A61L27/50 ,  A61L27/36 ,  C12M3/00 ,  A61L27/54 ,  C12M1/12 ,  A61L27/38 ,  A61L33/00 ,  C12M1/00 ,  C12M1/34 ,  G01N33/66

摘要： The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.

公开(公告)号：US11369497B2

公开(公告)日：2022-06-28

申请号：US16586639

申请日：2019-09-27

申请人： Covidien LP

发明人： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC分类号： A61M60/165 ,  A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

摘要： Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US11364116B2

公开(公告)日：2022-06-21

申请号：US17402704

申请日：2021-08-16

申请人： Tendyne Holdings, Inc.

发明人： Robert Vidlund ,  Kemal Schankereli ,  Lucian Lozonschi ,  Georg Lutter

IPC分类号： A61F2/24 ,  A61L27/34 ,  A61L27/36 ,  A61L33/00 ,  C08L67/04 ,  A61B17/04 ,  A61B17/064

摘要： This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

公开(公告)号：US11253539B2

公开(公告)日：2022-02-22

申请号：US16637912

申请日：2018-09-28

申请人： Toray Industries, Inc.

发明人： So Kakiyama ,  Koji Kadowaki ,  Kazuhiro Tanahashi

IPC分类号： A61K31/727 ,  A61K47/02 ,  A61K47/34 ,  A61L33/02 ,  A61L33/12 ,  A61L31/16 ,  A61L31/10 ,  A61L31/02 ,  A61L31/12 ,  A61L33/00

摘要： A medical material uses a nickel-titanium alloy wherein a polyelectrolyte has a reduced thickness while a sufficient amount of an antithrombogenic compound for production of a therapeutic effect is supported. The medical material in which a porous surface is formed on a nickel-titanium alloy to allow infiltration of a polyelectrolyte into the pores, to thereby reduce the thickness of the polyelectrolyte exposed on the surface of the nickel-titanium alloy while allowing supporting of a sufficient amount of an antithrombogenic compound due to contribution of the polyelectrolyte infiltrate.

公开(公告)号：US20210338420A1

公开(公告)日：2021-11-04

申请号：US17115812

申请日：2020-12-09

申请人： Sichuan University

发明人： Yunbing Wang ,  Gaoyang Guo ,  Li Yang

IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/54 ,  A61L33/00 ,  A61L33/12

摘要： A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

公开(公告)号：US11118067B2

公开(公告)日：2021-09-14

申请号：US15879526

申请日：2018-01-25

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Philseok Kim ,  Tak Sing Wong

IPC分类号： B05D3/00 ,  C09D5/00 ,  C09D5/16 ,  A61L27/28 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  B01L3/00 ,  B65D25/14 ,  H01L31/0236 ,  G02B1/14 ,  C10M105/54 ,  C10M105/56 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F28F13/18 ,  F28F19/02 ,  B05D5/00 ,  B01D69/02 ,  B05D5/08 ,  B63B59/04 ,  B64D15/00 ,  C02F1/44 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F16L57/00 ,  H01L31/0216

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20210253550A1

公开(公告)日：2021-08-19

申请号：US17245691

申请日：2021-04-30

申请人： eXIthera Pharmaceuticals, Inc.

发明人： Neil J. Hayward ,  Bertrand L. Chenard ,  Yuelian Xu ,  Roberta L. Dorow ,  Michael E. Matison ,  Alexander Kolchinski ,  Richard Fornicola

IPC分类号： C07D401/06 ,  A61P7/02 ,  A61L33/04 ,  A61L33/00

摘要： Provided herein are compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and compositions.