公开(公告)号：US12053479B2

公开(公告)日：2024-08-06

申请号：US17508951

申请日：2021-10-22

申请人： Madera Pharmaceuticals, Inc.

发明人： Michael Danzi ,  Charles Evans ,  Orla McCabe

IPC分类号： A61K31/5575 ,  A61K9/00 ,  A61K9/08 ,  A61K31/417 ,  A61K31/472 ,  A61K47/10 ,  A61P15/10

CPC分类号： A61K31/5575 ,  A61K9/0014 ,  A61K9/08 ,  A61K31/417 ,  A61K31/472 ,  A61K47/10 ,  A61P15/10

摘要： A transdermal treatment for erectile dysfunction includes an aqueous solution having a plurality of excipients and a combination of papaverine, phentolamine mesylate and prostaglandin E1.

公开(公告)号：US20230338304A1

公开(公告)日：2023-10-26

申请号：US18336288

申请日：2023-06-16

申请人： VELLA BIOSCIENCE, INC.

发明人： Harin Padma-Nathan ,  MIchael Frid ,  Helen Segil ,  Nial Chase DeMena

IPC分类号： A61K31/05 ,  A61K31/5575 ,  A61K36/88 ,  A61K31/4985 ,  A61K31/417 ,  A61K38/12 ,  A61K31/352 ,  A61K9/127 ,  A61P15/10 ,  A61K9/00 ,  A61K31/55 ,  A61K31/137 ,  A61K31/53 ,  A61K31/506 ,  A61K31/519 ,  A61K31/568 ,  A61K31/13 ,  A61K31/475 ,  A61K31/496 ,  A61K31/4458 ,  A61K31/472

CPC分类号： A61K31/05 ,  A61K31/5575 ,  A61K36/88 ,  A61K31/4985 ,  A61K31/417 ,  A61K38/12 ,  A61K31/352 ,  A61K9/127 ,  A61P15/10 ,  A61K9/0034 ,  A61K31/55 ,  A61K31/137 ,  A61K31/53 ,  A61K31/506 ,  A61K31/519 ,  A61K31/568 ,  A61K31/13 ,  A61K31/475 ,  A61K31/496 ,  A61K31/4458 ,  A61K31/472

摘要： The invention relates to compositions and methods containing hemp and/or cannabis-derived cannabidiol (CBD) for topical use in treating female sexual dysfunction induced by antidepressants, including, e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs), and other anti-depressants.

公开(公告)号：US11738027B2

公开(公告)日：2023-08-29

申请号：US17457269

申请日：2021-12-02

申请人： AstraZeneca AB

发明人： Andrew Whittaker ,  Hitesh Jayantilal Sanganee

IPC分类号： A61P15/10 ,  A61K31/519 ,  A61K31/505

CPC分类号： A61K31/519 ,  A61P15/10

摘要： The present disclosure relates to new therapeutic uses of MPO inhibitors and methods of treatment involving the same.

公开(公告)号：US20230142208A1

公开(公告)日：2023-05-11

申请号：US17906512

申请日：2021-03-23

申请人： CZAP RESEARCH AND DEVELOPMENT, LLC.

发明人： Al Czap

IPC分类号： A61K47/69 ,  A61K9/48 ,  A61K38/47 ,  A61P11/12 ,  A61P15/10 ,  A61K31/519 ,  A61K36/534 ,  A61K36/61 ,  A61K31/015

CPC分类号： A61K47/6951 ,  A61K9/4866 ,  A61K9/4858 ,  A61K38/47 ,  C12Y302/01001 ,  A61P11/12 ,  A61P15/10 ,  A61K31/519 ,  A61K36/534 ,  A61K36/61 ,  A61K31/015

摘要： The invention provides oral terpene cyclodextrin inclusion complex delivery vehicles, including formulations in which the cyclodextrin inclusion complex is provided together with enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin, so that upon delivery of the vehicle to a target the enzyme is activated and releases the guest molecule from the cyclodextrin cavity. In alternative aspects, these cyclodextrin inclusion complex delivery vehicles are for example provided in the form of time release formulations, for example for treatment of airway mucus dysfunction. Formulations are also provided with erectogenic efficacy.

公开(公告)号：US20230022570A1

公开(公告)日：2023-01-26

申请号：US17783873

申请日：2020-10-22

申请人： FUTURA MEDICAL DEVELOPMENTS LIMITED

发明人： Adrian DAVIS

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K31/5575 ,  A61K31/417 ,  A61K45/06 ,  A61P15/10 ,  A61L31/14 ,  G01N25/48

摘要： There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

公开(公告)号：US20220387447A1

公开(公告)日：2022-12-08

申请号：US17814591

申请日：2022-07-25

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MEDCARA PHARMACEUTICALS, LLC

发明人： Robert A. JOSEPHS ,  Craig HERMAN

IPC分类号： A61K31/568 ,  A61K47/14 ,  A61K47/44 ,  A61K9/00 ,  A61K9/107 ,  A61K9/12 ,  A61P15/10 ,  A61P25/22 ,  A61P15/08 ,  A61K31/573

摘要： The present disclosure relates to novel pharmaceutical composition for the administration of testosterone or testosterone derivatives using an aqueous nasal administration. The present disclosure also provides methods of treatment of diseases and disorders associated with fear and anxiety, a decrease in libido, or hypogonadism.

公开(公告)号：US11426448B2

公开(公告)日：2022-08-30

申请号：US16410789

申请日：2019-05-13

申请人： NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Carol Podlasek ,  Samuel I. Stupp ,  Kevin McVary ,  Dan Harrington

IPC分类号： A61K38/18 ,  A61P15/10 ,  C07K14/47 ,  A61K38/00 ,  C07K14/475

摘要： Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.

公开(公告)号：US20220248737A1

公开(公告)日：2022-08-11

申请号：US17728905

申请日：2022-04-25

申请人： CHINA NATIONAL RESEARCH INSTITUTE OF FOOD & FERMENTATION INDUSTRIES CO., LTD.

发明人： MUYI CAI ,  Ruizeng GU ,  Haixin ZHANG ,  WENYING LIU ,  YING WEI ,  LEI FANG ,  XINGCHANG PAN ,  ZHE DONG ,  LU LU ,  MING ZHOU ,  YUCHEN WANG ,  KONG LING ,  YUAN BI

IPC分类号： A23L33/18 ,  A23J1/04 ,  A23J3/04 ,  A23J3/34 ,  A23L17/00 ,  B01D21/26 ,  B01D71/02 ,  B01D15/36 ,  B01D15/32 ,  B01D15/18 ,  A23L5/20 ,  C07K14/435 ,  C07K1/36 ,  C07K1/18 ,  C07K1/20 ,  A61P15/10

摘要： An oyster peptide with an effect of improving sexual function and a preparation method thereof are provided, the oyster peptide at least includes peptide segments RI, IR and VR in its composition. Based on a mass of the oyster peptide, a content of the RI is ≥3.60 mg/100 g, a content of the IR is ≥7.60 mg/100 g, and a content of the VR is ≥6.50 mg/100 g.

公开(公告)号：US20220105153A1

公开(公告)日：2022-04-07

申请号：US17555374

申请日：2021-12-18

申请人： Xintrum Pharmaceuticals, Ltd.

发明人： Yi Zhang ,  Hai Chen ,  Gaoyong Liao

IPC分类号： A61K38/17 ,  A61P15/10

摘要： A long-acting preparation made from a protein having the amino acid sequence of SEQ ID NO. 1 or SEQ ID NO. 2 or from a modified protein of the protein for improving sexual dysfunction. The modified protein is the protein molecule connected with another protein or with another chemical substance.

公开(公告)号：US20210338757A1

公开(公告)日：2021-11-04

申请号：US16479798

申请日：2017-01-19

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Krishanu SENGUPTHA ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/22 ,  A61K36/38 ,  A61K45/06 ,  A23L33/105 ,  A61K9/00 ,  A61P15/10

摘要： The invention discloses synergistic compositions comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana for inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme or for increasing cGMP levels in a male subject. The invention further discloses a method of inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme, increasing cGMP levels and sexual arousal, treating/alleviating various aspects of male sexual dysfunction or impotence such as erectile dysfunction, loss of libido, or orgasm/ejaculation disorders in a male subject by using a suitable dose of synergistic composition comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana.