公开(公告)号：US20200330544A1

公开(公告)日：2020-10-22

申请号：US16756757

申请日：2018-10-16

申请人： LAILA NUTRACEUTICALS ,  P.L. THOMAS-LAILA NUTRACEUTICALS, INC.

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Venkateswara Rao CHIRRAVURI ,  Venkateswarlu SOMEPALLI ,  Kiran BHUPATHIRAJU

IPC分类号： A61K36/9066 ,  A61K36/75 ,  A23L33/105

摘要： Synergistic herbal compositions comprising combination of extracts, fractions or phytochemicals or mixtures thereof derived from Moringa oleifera, Murraya koenigii and Curcuma longa for increasing lean body mass and brown adipose tissue; for accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products. The invention further provides a method of increasing lean body mass and brown adipose tissue; accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products in mammals.

公开(公告)号：US12070481B2

公开(公告)日：2024-08-27

申请号：US16756757

申请日：2018-10-16

申请人： LAILA NUTRACEUTICALS ,  P.L. THOMAS-LAILA NUTRACEUTICALS, INC.

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venkateswara Rao Chirravuri ,  Venkateswarlu Somepalli ,  Kiran Bhupathiraju

IPC分类号： A61K36/9066 ,  A23L33/105 ,  A61K9/16 ,  A61K36/75

CPC分类号： A61K36/9066 ,  A23L33/105 ,  A61K36/75 ,  A61K9/16

摘要： Synergistic herbal compositions comprising combination of extracts, fractions or phytochemicals or mixtures thereof derived from Moringa oleifera, Murraya koenigii and Curcuma longa for increasing lean body mass and brown adipose tissue; for accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products. The invention further provides a method of increasing lean body mass and brown adipose tissue; accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products in mammals.

公开(公告)号：US20240058409A1

公开(公告)日：2024-02-22

申请号：US18453497

申请日：2023-08-22

申请人： P.L. THOMAS & CO., INC. ,  UNIVERSITY OF CONNECTICUT ,  LAILA NUTRACEUTICALS

发明人： Yanjiao Zhou ,  Seth Flowerman ,  Ganga Raju Gokaraju ,  Rama Raju Gokaraju

IPC分类号： A61K36/324 ,  A61K31/22 ,  A61K35/745 ,  A61P11/06 ,  A61P37/08

CPC分类号： A61K36/324 ,  A61K31/22 ,  A61K35/745 ,  A61P11/06 ,  A61P37/08

摘要： A gut microbiome may be modulated in a patient in need thereof, by administering a composition comprising 3-O-acetyl-11-keto-b-boswellic acid (AKBA) or an extract of Boswellia serrata comprising from 30% to 90% AKBA to the patient; wherein the composition is administered at a dose sufficient to change the ratio between a first organism in the gut microbiome and a second organism in the gut microbiome, compared to a subject not treated with the composition. Modulation of the gut microbiome with AKBA may be used to treat allergic pulmonary inflammation in the patient. Modulation of the gut microbiome with AKBA may be used to maintain diversity and/or increase a percentage of Bifidobacterium pseudolongum in the gut microbiome of the patient. The composition may further comprise a lyophilized probiotic bacteria. The composition may be administered in combination with a second composition comprising a lyophilized probiotic bacteria.

公开(公告)号：US20210338757A1

公开(公告)日：2021-11-04

申请号：US16479798

申请日：2017-01-19

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Krishanu SENGUPTHA ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/22 ,  A61K36/38 ,  A61K45/06 ,  A23L33/105 ,  A61K9/00 ,  A61P15/10

摘要： The invention discloses synergistic compositions comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana for inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme or for increasing cGMP levels in a male subject. The invention further discloses a method of inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme, increasing cGMP levels and sexual arousal, treating/alleviating various aspects of male sexual dysfunction or impotence such as erectile dysfunction, loss of libido, or orgasm/ejaculation disorders in a male subject by using a suitable dose of synergistic composition comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana.

公开(公告)号：US20210138014A1

公开(公告)日：2021-05-13

申请号：US16492473

申请日：2018-03-08

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Krishanu SENGUPTHA ,  Venkata Krishna Raju ALLURI ,  Venkateswarlu SOMEPALLI

IPC分类号： A61K36/54 ,  A61K36/22 ,  A61K36/31 ,  A61K36/71 ,  A61K36/8962

摘要： Synergistic herbal compositions for Testosterone boosting comprising at least two ingredients selected from the extracts, fractions or pure phytochemicals derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The present invention also describes a synergistic composition comprising at least one testosterone booster ingredient selected from the extracts, fractions or pure phytochemical derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica and at least one aromatase inhibitor ingredient selected from the extracts, fractions or pure phytochemicals derived from Allium cepa, Tamarindus indica and Cinnamomum tamala for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The invention further provides methods of improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans.

公开(公告)号：US10953067B2

公开(公告)日：2021-03-23

申请号：US15229710

申请日：2016-08-05

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakati ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri ,  Krishanu Sengupta

IPC分类号： A61K36/9066 ,  A61K36/185 ,  A61K36/324 ,  A61K45/06

摘要： An herbal composition, comprising a therapeutically effective amount of an extract of Terminalia chebula; a therapeutically effective amount of an extract of Curcuma longa; and a therapeutically effective amount of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin.

公开(公告)号：US10471114B2

公开(公告)日：2019-11-12

申请号：US14951175

申请日：2015-11-24

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/38 ,  A61K36/28 ,  A61K35/12 ,  A23L33/105

摘要： Pharmaceutical/dietary supplements and food ingredient(s) derived from Sphaeranthus indicus are used for controlling or treating a metabolic disorder. The supplements and food ingredient(s) are selected from Sphaeranthus indicus extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

公开(公告)号：US20140056987A1

公开(公告)日：2014-02-27

申请号：US14065583

申请日：2013-10-29

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupthiraju ,  Venkata Krishna Raju Alluri ,  Krishanu Sengupta

IPC分类号： A61K36/185 ,  A61K36/9066 ,  A61K36/19 ,  A61K31/202 ,  A61K31/355 ,  A61K31/198 ,  A61K36/324 ,  A61K31/375

CPC分类号： A61K36/185 ,  A61K31/07 ,  A61K31/198 ,  A61K31/202 ,  A61K31/355 ,  A61K31/365 ,  A61K31/375 ,  A61K31/592 ,  A61K31/714 ,  A61K33/04 ,  A61K33/06 ,  A61K35/612 ,  A61K36/19 ,  A61K36/324 ,  A61K36/9066 ,  A61K2300/00

摘要： The invention discloses synergistic composition comprising at least one Annona squamosa derived component standardized to acetogenin compound(s) having α,β-unsaturated-γ-methyl-γ-lactone moiety in combination with at least one biologically active ingredient derived from plants, animals or microorganisms such as vitamins, amino acids, minerals, fibers, various plant and herbal extracts for the prevention, treatment, inhibition or controlling inflammation and/or metabolic disorders and other associated or related diseases. The invention further discloses the method of treating inflammation and/or metabolic disorders and other associated or related diseases.

摘要翻译： 本发明公开了包含至少一种标准化为具有α，β-不饱和-γ-甲基-γ-内酯部分的乙酰辅酶化合物与至少一种源自植物，动物或生物活性成分的生物活性成分的Annona squamosa衍生组分的协同组合物 微生物如维生素，氨基酸，矿物质，纤维，各种植物和草药提取物，用于预防，治疗，抑制或控制炎症和/或代谢紊乱以及其它相关或相关疾病。 本发明还公开了治疗炎症和/或代谢紊乱及其它相关或相关疾病的方法。

公开(公告)号：US11903991B2

公开(公告)日：2024-02-20

申请号：US17201865

申请日：2021-03-15

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakati ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri ,  Krishanu Sengupta

IPC分类号： A61K36/00 ,  A61K36/9066 ,  A61K36/185 ,  A61K36/324 ,  A61K45/06

CPC分类号： A61K36/9066 ,  A61K36/185 ,  A61K36/324 ,  A61K45/06 ,  A61K2236/15 ,  A61K2236/31 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/35 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/55 ,  A61K36/185 ,  A61K2300/00 ,  A61K36/324 ,  A61K2300/00 ,  A61K36/9066 ,  A61K2300/00

摘要： A method for treating an inflammation, arthritis, or a joint disease in a patient in need thereof, comprising administering to the patient an herbal composition, where the herbal composition includes a therapeutically effective amount of an extract of Terminalia chebula; a therapeutically effective amount of an extract of Curcuma longa; and a therapeutically effective amount of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin.

公开(公告)号：US20230346736A1

公开(公告)日：2023-11-02

申请号：US18012411

申请日：2021-06-23

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Kiran BHUPATHIRAJU ,  Venkata Krishna Raju ALLURI ,  Venkateswarlu SOMEPALLI ,  Krishanu SENGUPTHA

IPC分类号： A61K31/22 ,  A61P21/00 ,  A61K33/00

CPC分类号： A61K31/22 ,  A61K33/00 ,  A61P21/00

摘要： The present invention discloses water-soluble 3-O-acetyl-11-keto-β-boswellic acid compositions comprising 3-O-acetyl-11-keto-β-boswellic acid in combination with a metal ion selected from potassium or sodium in the form of respective metal salt or complex or chelate; process for their preparation; methods of prevention, control and/or treatment of at least one disorder selected from muscle soreness, delayed-onset of muscle soreness (DOMS), muscles tenderness, muscle pain, muscle fatigue, muscle sprain, temporary loss of muscle strength and swelling in muscles.