公开(公告)号：US20240270678A1

公开(公告)日：2024-08-15

申请号：US18567037

申请日：2022-12-22

申请人： SUN CHEMICAL CORPORATION

发明人： Jürgen DIEKER ,  Florian MAESING

IPC分类号： C07C225/22 ,  C07C227/16 ,  C07C229/42 ,  C09D11/101

CPC分类号： C07C225/22 ,  C07C227/16 ,  C07C229/42 ,  C09D11/101

摘要： The present invention relates to amine synergists comprising the structure element of a substituted 1,3-propanedione and their use in radiation or energy curing by actinic light. The amine synergists of the present invention are particularly useful for printing and coating materials wherein low migration and/or low odor is required, such as food packaging and other sensitive packaging applications.

公开(公告)号：US20240092726A1

公开(公告)日：2024-03-21

申请号：US18123356

申请日：2023-03-20

申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY ,  ZHEJIANG CHANGHAI PHARMACEUTICALS CO., LTD.

发明人： Li SHENG ,  Yuquan LUO ,  Gang FAN ,  Long CHEN ,  Junwei CHEN ,  Chunlei LV ,  Guofeng WU ,  Dadong SHEN ,  Lin ZHAO ,  Yunxia GONG

IPC分类号： C07C227/44 ,  B01J19/00 ,  C07C227/16

CPC分类号： C07C227/44 ,  B01J19/0093 ,  C07C227/16 ,  B01J2219/00824

摘要： The present disclosure discloses a method for synthesizing quinolones intermediates by a continuous flow reaction. Specifically, according to the method, a microchannel reactor is used, which improves the selectivity and conversion rate of the reaction, and the conversion rate of compound ii is increased to more than 95% and the yield is increased to more than 85%; avoids the use of a solvent such as methanol, and methyl tert-butyl ether, etc., in the intermittent reaction process, which simplifies the post-processing method, shortens the overall operation time from about 24 hours to a few minutes, greatly improving the production efficiency, and realizing the continuity and automation of the whole process; and thus makes the product have high purity and high yield, which is suitable for industrial production.

公开(公告)号：US11926697B2

公开(公告)日：2024-03-12

申请号：US17270593

申请日：2020-08-20

申请人： SOOCHOW UNIVERSITY

发明人： Zhenping Cheng ,  Kai Tu ,  Enjie He ,  Jiannan Cheng ,  Lifen Zhang ,  Xiulin Zhu

IPC分类号： C08G61/12 ,  B29C55/00 ,  B29C55/04 ,  C07C227/16 ,  C08J5/18 ,  C09K19/38 ,  F04B49/00 ,  G08C23/04 ,  B29K105/00 ,  B29L7/00

CPC分类号： C08G61/121 ,  B29C55/005 ,  B29C55/04 ,  C07C227/16 ,  C08J5/18 ,  C09K19/3804 ,  F04B49/00 ,  G08C23/04 ,  B29K2105/0079 ,  B29L2007/008 ,  C08G2261/124 ,  C08G2261/316 ,  C08G2261/53 ,  C08G2261/76 ,  C08J2365/00

摘要： The present invention provides a fluorine-containing liquid crystal polymer of Formula (1). The present invention also discloses a fluorine-containing liquid crystal elastomer, which comprises a copolymer of a fluorine-containing liquid crystal polymer of Formula (1) with a near-infrared dye of Formula (2). The fluorine-containing liquid crystal elastomer of the present invention shrinks due to the photothermal conversion effect of the material under the irradiation of near-infrared light, and thus is widely applicable to the field of actuators. The fluorine-containing liquid crystal polymer of the present invention introduces fluorine-containing segments into the cross-linked network of the liquid crystal polymer, to improve the mechanical performance of the material, and greatly extend the service time of light-controlled actuators.

公开(公告)号：US20230357130A1

公开(公告)日：2023-11-09

申请号：US18221075

申请日：2023-07-12

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

CPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US11591287B2

公开(公告)日：2023-02-28

申请号：US16619699

申请日：2018-06-06

申请人： Wayne State University

发明人： Zhiqiang Cao ,  Wei Wang

IPC分类号： C07C229/22 ,  A61K31/337 ,  A61K35/76 ,  A61K38/28 ,  A61K39/00 ,  A61K39/39 ,  A61K47/54 ,  A61K47/58 ,  A61K47/69 ,  B32B7/12 ,  B32B27/08 ,  C07C227/16 ,  C08F120/36 ,  C08G81/02 ,  C09D5/16 ,  C09D133/14 ,  C09D133/26 ,  C12N15/86 ,  A61L27/34 ,  A61L27/52 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  C08F220/36 ,  C08L33/04

摘要： Compositions are provided according to aspects of the present invention that include a hydrogel and a liner, wherein a surface of the hydrogel dissociably-engages a surface of the liner. Compositions are provided according to aspects of the present invention that include a hydrogel and a hydrophobic glue, wherein at least a portion of the gel network of the hydrogel is occupied by the hydrophobic glue. Reverse coaling processes and articles of manufacture made by reverse coating processes are provided according to aspects of the present invention. Compositions are provided according to aspects of the present invention that include a hydrogel and a substrate, wherein: the hydrogel comprises a polymer network; the substrate comprises a surface comprising a polymer network; and the polymer network of the hydrogel and the polymer network of the surface are entangled.

公开(公告)号：US20220380299A1

公开(公告)日：2022-12-01

申请号：US17538217

申请日：2021-11-30

申请人： ModernaTX, Inc.

发明人： Kerry E. BENENATO ,  Mark CORNEBISE

IPC分类号： C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K47/54 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  C07C233/72 ,  C07C263/20 ,  A61K9/16 ,  A61K38/18 ,  A61K48/00 ,  C07K14/505 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20220073449A1

公开(公告)日：2022-03-10

申请号：US17525352

申请日：2021-11-12

申请人： ModernaTX, Inc.

发明人： Orn ALMARSSON ,  Eugene CHEUNG

IPC分类号： C07C229/24 ,  C07C55/07 ,  C07C65/03 ,  C07C227/16 ,  C07C229/12

摘要： Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

公开(公告)号：US11220476B2

公开(公告)日：2022-01-11

申请号：US16555045

申请日：2019-08-29

申请人： ModernaTX, Inc.

发明人： Kerry E. Benenato ,  Mark Cornebise

IPC分类号： C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K47/54 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  C07C233/72 ,  C07C263/20 ,  A61K9/16 ,  A61K38/18 ,  A61K48/00 ,  C07K14/505 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20210276942A1

公开(公告)日：2021-09-09

申请号：US16967627

申请日：2019-02-11

申请人： VISTAGEN THERAPEUTICS, INC.

发明人： Daniel LEVIN ,  Peter LEEMING ,  Emerich EISENREICH ,  Xuejun Karl LIU

IPC分类号： C07C227/18 ,  C07C227/32 ,  C07C227/16 ,  C07C269/06 ,  C07C271/22 ,  C07C229/36 ,  C07C227/40

摘要： The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

公开(公告)号：US20210009507A1

公开(公告)日：2021-01-14

申请号：US17042323

申请日：2019-03-29

申请人： Heidelberg Pharma Research GmbH ,  Corden Pharma International GmbH

发明人： Caroline Knittel ,  Mary-Ann Siegert ,  Roderich Süssmuth ,  Christoph Wink ,  Gerhard Jas

IPC分类号： C07C227/16 ,  A61K31/439 ,  B01J21/06 ,  C07D493/10 ,  C07D493/20 ,  C07D319/20 ,  C07F7/18

摘要： The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.