公开(公告)号：US11505518B2

公开(公告)日：2022-11-22

申请号：US16634311

申请日：2018-07-26

申请人： INALCO S.R.L.

发明人： Giovanni Cipolletti ,  Luana Vagnoli ,  Marina Matulli ,  Barbara Febbruari ,  Jacopo Chini

IPC分类号： C07C37/00 ,  C07C37/84 ,  C07C37/50 ,  B01D11/02 ,  B01D11/04

摘要： The present invention describes a process for the production of (−)-cannabidiol (CBD) from industrial hemp by means of an extraction followed by two alternative working processes: a process A which provides extraction with solvents first to an alkaline pH and then to acidic pH to isolate the carboxyl form of the CBD which is then subjected to decarboxylation and a process B which provides the elimination of waxes and pitches and then purification by chromatography. At the end of both alternative working processes the CBD is crystallized obtained in high purity crystalline form.

公开(公告)号：US20220324779A1

公开(公告)日：2022-10-13

申请号：US17634271

申请日：2020-08-14

申请人： Elvis O. Ebikade ,  Eric R. Gottlieb ,  Robert M. O'Dea ,  Thomas H. Epps, III ,  Dionisios Vlachos

发明人： Elvis O. Ebikade ,  Eric R. Gottlieb ,  Robert M. O'Dea ,  Thomas H. Epps, III ,  Dionisios Vlachos

IPC分类号： C07C37/00 ,  C07C41/18 ,  B01D3/00 ,  B01D36/00

摘要： Disclosed herein are systems and methods of depolymerizing a lignin component of a lignin-containing material. The method comprising contacting the lignin-containing material with a solvent and optionally a catalyst at a temperature in the range of 180-300° C. and at a maximum operating pressure of less than 10 barG during the depolymerization of the lignin component of the material and collecting at least one volatile stream comprising one or more depolymerized lignin products. In an embodiment, the step of contacting is carried out in a reactive distillation reactor, and the step of collecting comprises concurrently collecting at least one volatile stream via distillation apparatus connected to the reactive distillation reactor, at least one of the one or more depolymerized lignin products comprises a substituted phenol having the following general formula: (I) wherein R1 is H, methyl, ethyl, n-propyl, propenyl, or allyl, and R2 and R3 are independently selected from H or methoxy group.

公开(公告)号：US11274177B2

公开(公告)日：2022-03-15

申请号：US16411422

申请日：2019-05-14

申请人： International Business Machines Corporation

发明人： Brandon M. Kobilka ,  Jacob Porter ,  Jason T. Wertz ,  Scott B. King

IPC分类号： C08G18/32 ,  C08G63/20 ,  C07C37/00 ,  C07C39/11 ,  C08G18/76 ,  C08G63/133 ,  C08G63/06 ,  C08G63/127

摘要： A terminally-functionalized derivative of a cashew nut shell liquid (CNSL) compound, a method to form a polymer, and an article of manufacture comprising a polymer derived from the terminally-functionalized CNSL derivative. The terminally-functionalized CNSL derivative has two, three, four, or five reactive functional groups. The polymer is prepared by obtaining CNSL compounds, reacting the CNSL compounds to form the terminally-functionalized CNSL derivative, and polymerizing the terminally-functionalized CNSL derivative.

公开(公告)号：US20220017839A1

公开(公告)日：2022-01-20

申请号：US16930853

申请日：2020-07-16

申请人： Tread Heads, LLC

发明人： Bryce W. Powell

IPC分类号： C11B9/02 ,  C07D311/78 ,  C07C37/00 ,  B01D11/02

摘要： The separation of essential oils from a botanical biomass can be accomplished in a more effective way and with higher yields using microwaves to extract essential oils by dry or azeotropic distillation and isolating products from the essential oils.

公开(公告)号：US11117852B2

公开(公告)日：2021-09-14

申请号：US16603226

申请日：2018-04-04

申请人： University of Mississippi

发明人： Mahmoud A. ElSohly ,  Waseem Gul ,  Mohamed M. Radwan ,  Amira Samir Wanas

IPC分类号： C07C37/74 ,  C07C37/82 ,  A01H6/28 ,  A61K31/05 ,  C07C37/00 ,  C07C37/86 ,  C07C39/23 ,  G01N30/02 ,  G01N30/88

摘要： Δ9-Tetrahydrocannabinol (Δ9-THC or THC) and cannabidiol (CBD) are major constituents of the Cannabis plant that have pharmacological properties with potential therapeutic value. This invention is directed to processes for large scale isolation of these two and other cannabinoids from the Cannabis sativa plant. This is accomplished through the discovery that protected amino acid esters of the cannabinoids are easier to separate using normal phase silica column chromatography. Mild base hydrolysis of the esters regenerates the free cannabinoids in a purified form. The invention is also applicable to the isolation of other cannabinoids from Cannabis extracts.

公开(公告)号：US11116745B2

公开(公告)日：2021-09-14

申请号：US15929099

申请日：2019-01-31

申请人： Deep Cell Industries, Inc.

发明人： James Gerstenberger ,  Kelly Ogilvie

IPC分类号： A61K31/352 ,  A61K9/16 ,  B01D9/00 ,  C07C51/43 ,  B01D21/00 ,  B01D11/02 ,  A61K9/14 ,  C07C37/00

摘要： A method of generating an oligosaccharide encapsulated cannabidiol (CBD) formulation includes forming a cannabidiol ethanol mixture comprising ethanol and cannabidiol, forming an oligosaccharide CBD slurry by mixing the oligosaccharide with the cannabidiol ethanol mixture. The slurry is heated and mixed in a pressurized chamber to form a colloidal mixture, which is distributed into a tray as a layer. A cover is added to the tray to form an evaporation vessel, which is heated in a heating chamber. A rapid cooling process is performed on the colloidal mixture layer by removing the cover and spraying pulverized dry ice on the layer. The rapid cooling process is repeated until crystal formation is detected within the layer, the crystals including oligosaccharide encapsulated cannabidiol. An oligosaccharide encapsulated cannabidiol formulation includes cannabidiol and at least one oligosaccharide in a ratio in the range between about 1000:1 to 2200:1 (w/w) of CBD.

公开(公告)号：US11084770B2

公开(公告)日：2021-08-10

申请号：US16266326

申请日：2019-02-04

申请人： Treehouse Biotech, Inc.

发明人： Jacob Black ,  Ryan Beigie ,  Alex Mateo

IPC分类号： C07C37/72 ,  B01D15/32 ,  G01N30/02 ,  C07C39/23 ,  C07D311/78 ,  C07B63/00 ,  A61K31/352 ,  A61K36/185 ,  C07C37/00 ,  G01N30/88 ,  G01N30/90

摘要： A method is provided for removing THC from raw cannabis oil.

公开(公告)号：US20210187414A1

公开(公告)日：2021-06-24

申请号：US17267674

申请日：2019-08-28

申请人： RADD Scientific Inc.

发明人： David BRUCE ,  Toby ASTILL ,  Martin RASKA ,  Dean SCODELLARO

IPC分类号： B01D11/02 ,  C07D311/78 ,  C07C37/00 ,  G01N21/3577

摘要： Systems and methods of extracting compounds from botanical matter are provided. The system includes: a solvent source; an extraction vessel which receives botanical matter from which compounds, including at least one target compound are extracted into a solution; a detector that obtains real time information the compounds; a separation vessel for separating the target compound from the solution; a throttle located between the extraction vessel and the separation vessel for controlling flow of the solution; and a controller connected to the detector and the at the throttle for receiving and processing the real time information and controlling, via the throttle, flow rate of the solution from the extraction vessel to the separation vessel based at least partly on the processed real time information about the compounds.

公开(公告)号：US20210163388A1

公开(公告)日：2021-06-03

申请号：US17174566

申请日：2021-02-12

申请人： Dermavant Sciences GmbH

发明人： Ian Paul ANDREWS ,  Nicholas CALANDRA ,  Tyler Andrew DAVIS ,  Ravinder Reddy SUDINI

IPC分类号： C07C39/08 ,  C07C37/00 ,  C07C50/24 ,  C07C51/38 ,  C07C69/716 ,  C07C67/03 ,  C07C67/293 ,  C07C59/353 ,  C07C45/63 ,  C07C51/09 ,  C07C67/343 ,  C07C45/72 ,  C07C45/54 ,  C07C37/07

摘要： The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

公开(公告)号：US10954208B2

公开(公告)日：2021-03-23

申请号：US16789467

申请日：2020-02-13

申请人： Plantbiosis Ltd.

发明人： Dylan James Webb ,  Paul George Hayes ,  Igor Kovalchuk

IPC分类号： A61K36/00 ,  C07D311/78 ,  C07C37/00

摘要： The present invention provides methods of extraction of at least one cannabinoid from an initial cannabis biomass in “one-pot” step using toluene to form a toluene extract and using the toluene extract for producing high concentrations of Δ-9-tetrahydrocannabinol (Δ9THC) and/or cannabinol (CBN) of a purity of at least 75% and at a yield of at least 75% by weight of the at least one cannabinoid from the initial cannabis biomass in the toluene extract.