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公开(公告)号：US20230174445A1
公开(公告)日：2023-06-08
申请号：US18164309
申请日：2023-02-03
Applicant: Dermavant Sciences GmbH
Inventor： Ian Paul ANDREWS , Nicholas CALANDRA , Tyler Andrew DAVIS , Ravinder Reddy SUDINI
IPC: C07C39/08 , C07C37/00 , C07C50/24 , C07C51/38 , C07C69/716 , C07C67/03 , C07C67/293 , C07C59/353 , C07C45/63 , C07C51/09 , C07C67/343 , C07C45/72 , C07C45/54 , C07C37/07
CPC classification number: C07C39/08 , C07C37/002 , C07C50/24 , C07C51/38 , C07C69/716 , C07C67/03 , C07C67/293 , C07C59/353 , C07C45/63 , C07C51/09 , C07C67/343 , C07C45/72 , C07C45/54 , C07C37/07 , A61K31/05
Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.
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2.发明申请公开(公告)号：US20170182486A1
公开(公告)日：2017-06-29
申请号：US15129853
申请日：2015-03-30
Applicant: The University of Chicago
Inventor： Wenbin Lin, Ph.D. , Kuntal Manna , Teng Zhang
IPC: B01J31/16 , C07F5/02 , C07F7/18 , C07C5/03 , C07C41/20 , C07D207/04 , C07D207/06 , C07C209/02 , B01J31/18 , C07C37/07
CPC classification number: B01J31/1691 , B01J31/18 , B01J31/1815 , B01J2531/16 , B01J2531/48 , B01J2531/824 , B01J2531/827 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07C5/03 , C07C37/07 , C07C41/20 , C07C209/02 , C07D207/04 , C07D207/06 , C07F5/025 , C07F7/1876 , Y02P20/544
Abstract: Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.
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公开(公告)号：US09579632B2
公开(公告)日：2017-02-28
申请号：US13990440
申请日：2011-12-02
Applicant: Jihad M. Dakka , Lorenzo C. DeCaul , Terry E. Helton , Keith H. Kuechler , Jenna L. Wallace
Inventor： Jihad M. Dakka , Lorenzo C. DeCaul , Terry E. Helton , Keith H. Kuechler , Jenna L. Wallace
CPC classification number: B01J23/626 , B01J21/08 , B01J23/24 , B01J23/32 , B01J35/0066 , B01J37/0207 , C07C37/06 , C07C37/07 , Y02P20/52 , C07C39/04
Abstract: A catalyst composition comprises (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound, wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt %, the wt % based upon the total weight of the catalyst composition.
Abstract translation: 催化剂组合物包含（i）载体; （ii）包含选自元素周期表第6至10族的至少一种金属或其化合物的脱氢组分; 和（iii）锡或锡化合物，其中锡的存在量为0.01重量％至约0.25重量％，基于催化剂组合物的总重量的wt％。
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公开(公告)号：US09233887B2
公开(公告)日：2016-01-12
申请号：US13885611
申请日：2011-11-04
Applicant: Jihad M. Dakka , Teng Xu , Edward A. Lemon , James R. Lattner , Jane C. Cheng
Inventor： Jihad M. Dakka , Teng Xu , Edward A. Lemon , James R. Lattner , Jane C. Cheng
CPC classification number: C07C2/66 , C07C37/07 , C07C37/08 , C07C45/53 , C07C2529/08 , C07C2529/18 , C07C2529/70 , Y02P20/127 , C07C13/28
Abstract: In a process for producing mono-cycloalkyl-substituted aromatic compound, benzene and cyclic monoolefin are contacted with a catalyst under alkylation conditions to produce an effluent containing mono-cycloalkyl-substituted aromatic compound. The catalyst comprises a molecular sieve.
Abstract translation: 在制备单环烷基取代的芳族化合物的方法中，苯和环状单烯烃在烷基化条件下与催化剂接触以产生含有单环烷基取代的芳族化合物的流出物。 催化剂包括分子筛。
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公开(公告)号：US09035107B2
公开(公告)日：2015-05-19
申请号：US13515057
申请日：2010-12-17
Applicant: Teng Xu , Stuart L. Soled , Edward A. Lemon , Joseph E. Baumgartner , Sabato Miseo , George H. Gamble
Inventor： Teng Xu , Stuart L. Soled , Edward A. Lemon , Joseph E. Baumgartner , Sabato Miseo , George H. Gamble
CPC classification number: B01J23/42 , B01J21/08 , B01J37/0203 , C07C5/367 , C07C37/07 , C07C37/08 , C07C2523/58 , Y02P20/52 , C07C15/04 , C07C39/04
Abstract: In a process for the dehydrogenation of dehydrogenatable hydrocarbons, a feed comprising dehydrogenatable hydrocarbons is contacted with a catalyst comprising a support and a dehydrogenation component under dehydrogenation conditions effective to convert at least a portion of the dehydrogenatable hydrocarbons in the feed. The catalyst is produced by a method comprising treating the support with a liquid composition comprising the dehydrogenation component or a precursor thereof and at least one organic dispersant selected from an amino alcohol and an amino acid.
Abstract translation: 在可脱氢烃脱氢的方法中，包含可脱氢烃的进料在有效转化进料中至少一部分可脱氢烃的脱氢条件下与包含载体和脱氢组分的催化剂接触。 催化剂通过包括用包含脱氢组分或其前体的液体组合物和至少一种选自氨基醇和氨基酸的有机分散体处理载体的方法制备。
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Patent Agency Ranking
公开(公告)号：US09029611B2
公开(公告)日：2015-05-12
申请号：US13512796
申请日：2010-12-17
Applicant: Teng Xu , Jihad M. Dakka , Christopher L. Becker , Keith H. Kuechler , Francisco M. Benitez , Charles M. Smith , Hari Nair
Inventor： Teng Xu , Jihad M. Dakka , Christopher L. Becker , Keith H. Kuechler , Francisco M. Benitez , Charles M. Smith , Hari Nair
CPC classification number: C07C2/74 , C07C37/07 , C07C37/08 , C07C45/53 , C07C407/00 , C07C2529/70 , C07C2529/74 , C07C2601/14 , C07C13/28 , C07C39/04 , C07C49/403 , C07C409/14
Abstract: In a process for the dehydrogenation of cyclohexanone to produce phenol, a feed comprising cyclohexanone is contacted with a dehydrogenation catalyst under dehydrogenation conditions comprising a temperature of less than 400° C. and a pressure of less than 690 kPa, gauge, such 0.1 to 50 wt % of the cyclohexanone in said feed is converted to phenol and the dehydrogenation product contains less than 100 ppm by weight of alkylbenzenes.
Abstract translation: 在环己酮脱氢生产苯酚的方法中，将包含环己酮的进料与脱氢催化剂在脱氢条件下接触，脱氢条件包括温度低于400℃，压力小于690kPa，表压0.1至50 所述进料中环己酮的重量％转化为苯酚，脱氢产物含有小于100重量ppm的烷基苯。
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公开(公告)号：US20140330044A1
公开(公告)日：2014-11-06
申请号：US14347279
申请日：2012-08-29
Applicant: Keith H. Kuechler , James R. Lattner , Christopher L. Becker
Inventor： Keith H. Kuechler , James R. Lattner , Christopher L. Becker
IPC: C07C37/07 , C07C49/403
CPC classification number: C07C37/07 , C07C2/74 , C07C37/08 , C07C45/53 , C07C49/403 , C07C407/00 , C07C2529/70 , C07C2601/14 , C07C13/28 , C07C409/14 , C07C39/04
Abstract: In a process for producing phenol, cyclohexylbenzene hydroperoxide is cleaved to produce a cleavage effluent stream comprising phenol and cyclohexanone and at least a portion of the cleavage effluent stream is fractionated to produce a first fraction richer in cyclohexanone than the cleavage effluent stream portion and a second fraction richer in phenol and depleted in cyclohexanone as compared with said cleavage effluent stream portion. At least a portion of the second fraction is then contacted with a dehydrogenation catalyst in a dehydrogenation reaction zone under dehydrogenation conditions effective to convert at least a portion of the cyclohexanone in said second fraction portion into phenol and cyclohexanol.
Abstract translation: 在生产苯酚的方法中，将环己基苯氢过氧化物切割以产生包含苯酚和环己酮的裂解流出料流，并将至少一部分裂解流出物流分馏以产生比裂解流出物流部分富含环己酮的第一馏分，第二馏分 与所述裂解流出物流部分相比，苯酚中的馏分比较富含，耗尽环己酮。 然后在有效将至少一部分所述第二级分部分中的环己酮转化成苯酚和环己醇的脱氢条件下，至少部分第二馏分与脱氢催化剂在脱氢反应区中接触。
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公开(公告)号：US20140066663A1
公开(公告)日：2014-03-06
申请号：US13990440
申请日：2011-12-02
Applicant: Jihad M. Dakka , Lorenzo C. DeCaul , Terry E. Helton , Keith H. Kuechier , Jenna L. Waliace
Inventor： Jihad M. Dakka , Lorenzo C. DeCaul , Terry E. Helton , Keith H. Kuechier , Jenna L. Waliace
CPC classification number: B01J23/626 , B01J21/08 , B01J23/24 , B01J23/32 , B01J35/0066 , B01J37/0207 , C07C37/06 , C07C37/07 , Y02P20/52 , C07C39/04
Abstract: A catalyst composition comprises (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound, wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt %, the wt % based upon the total weight of the catalyst composition.
Abstract translation: 催化剂组合物包含（i）载体; （ii）包含选自元素周期表第6至10族的至少一种金属或其化合物的脱氢组分; 和（iii）锡或锡化合物，其中锡的存在量为0.01重量％至约0.25重量％，基于催化剂组合物的总重量的wt％。
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公开(公告)号：US08487140B2
公开(公告)日：2013-07-16
申请号：US12996219
申请日：2009-07-14
Applicant: John S. Buchanan , Jon E. Stanat , Tan-Jen Chen , Jihad M. Dakka , James R. Lattner
Inventor： John S. Buchanan , Jon E. Stanat , Tan-Jen Chen , Jihad M. Dakka , James R. Lattner
CPC classification number: C07C37/06 , C07C2/74 , C07C37/08 , C07C45/53 , C07C407/00 , C07C2601/14 , C07C13/28 , C07C39/04 , C07C49/403 , C07C409/14
Abstract: In a process for producing phenol, cyclohexylbenzene is oxidized to produce cyclohexylbenzene hydroperoxide and then the resultant cyclohexylbenzene hydroperoxide is cleaved to produce an effluent stream comprising phenol and cyclohexanone. At least a portion of the effluent stream is then fed to at least one dehydrogenation reaction zone, where the effluent stream portion is contacted with a dehydrogenation catalyst under conditions effective to convert at least part of the cyclohexanone in the effluent portion into phenol and hydrogen.
Abstract translation: 在生产苯酚的方法中，将环己基苯氧化生产环己基苯氢过氧化物，然后将所得的环己基苯氢过氧化物切割以产生包含苯酚和环己酮的流出物流。 然后将至少一部分流出物流送入至少一个脱氢反应区，其中流出物流部分与脱氢催化剂在有效地将流出物部分中的至少一部分环己酮转化为酚和氢的条件下接触。
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公开(公告)号：US20050137409A1
公开(公告)日：2005-06-23
申请号：US11008029
申请日：2004-12-09
Applicant: Sunil Ashtekar , Pramod Kumbhar , Jan-Pleun Lens , Rathinam Mahalingam , Nadkarni Pradeep , Jegadeesh Thampi
Inventor： Sunil Ashtekar , Pramod Kumbhar , Jan-Pleun Lens , Rathinam Mahalingam , Nadkarni Pradeep , Jegadeesh Thampi
Abstract: A process for the preparation of benzoquinones and hydroquinones includes oxidizing an aromatic hydroxy compound with oxygen or an oxygen containing gas, a copper containing catalyst, and optionally a promoter to form the benzoquinone. A reduction reaction is employed to form the hydroquinone.
Abstract translation: 制备苯醌和氢醌的方法包括用氧或含氧气体氧化芳族羟基化合物，含铜催化剂和任选的助催化剂以形成苯醌。 采用还原反应形成氢醌。
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