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    SYSTEM FOR PROVIDING MULTIPLE INFUSIONS TO A PATIENT
    3.
    发明申请
    SYSTEM FOR PROVIDING MULTIPLE INFUSIONS TO A PATIENT 审中-公开

    公开(公告)号：WO2019001879A1

    公开(公告)日：2019-01-03

    申请号：PCT/EP2018/064066

    申请日：2018-05-29

    Applicant: FRESENIUS VIAL SAS ,  RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN

    Inventor： COTTIN, Pauline ,  GUERRINI, Alexandre ,  DOESBURG, Frank ,  NIJSTEN, Maarten

    IPC: A61M5/14 ,  A61M5/172 ,  A61M5/168 ,  G06F19/00

    Abstract: A system for providing multiple infusions to a patient (P), the system comprises a multiplicity of infusion devices (10) for administering a multiplicity of medical fluids through an infusion line (102) of an infusion set (103) to the patient (P), and a control device (2) for controlling the multiplicity of infusion devices (10). Herein, the control device (2) comprises a multiplex module (22) configured to multiplex the multiplicity of medical fluids for a multiplexed administration of the medical fluids through said infusion line (102) of the infusion set (103), the multiplex module (22) comprising a scheduling module (222) configured to define at least two packets, each packet comprising at least one medical fluid out of the multiplicity of medical fluids, and to arrange the at least two packets in a sequence for administration of the medical fluids of the at least two packets. In this way a system for providing multiple infusions to a patient is provided which allows for an efficient, yet reliable administration of multiple infusions while at the same time reducing the risks for errors. An advantage of multiplexing is reduction of the number of lumens with associated reduction of infection risks and discomfort.

    METHODS AND KITS FOR THE DERIVATIZATION OF A BIOGENIC AMINE
    4.
    发明申请
    METHODS AND KITS FOR THE DERIVATIZATION OF A BIOGENIC AMINE 审中-公开
    用于衍生生物胺的方法和试剂盒

    公开(公告)号：WO2017204637A1

    公开(公告)日：2017-11-30

    申请号：PCT/NL2017/050332

    申请日：2017-05-24

    Applicant: RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN

    Inventor： KEMA, Ido Peter ,  VAN DER LEY, Claude Pascal ,  VAN FAASSEN, Hermannus Johannes Roelof

    IPC: G01N33/94 ,  G01N33/68

    Abstract: The invention relates to analytical chemistry, in particular to means and methods for the quantitative determination of derivatized biogenic amines, precursors or metabolites thereof. Provided is a method for the in situ derivatization of at least one biogenic amine, precursor or metabolite thereof in an isolated aqueous sample, the derivatization comprising the steps of: (i) contacting said sample with a propionic anhydride / acetonitril solution in the presence of a phosphate buffer having a pH in the range of 7.0 to 9.0 and allowing the conversion of amine and/or hydroxyl moieties of said biogenic amine or metabolite thereof to form a propionyl derivative of said biogenic amine; followed by (ii) adding to the reaction mixture obtained in step (i) a carbodiimide compound and an electrophilic amine-containing compound, and allowing the carbodiimide-mediated derivatization of carboxylic acid moieties of a biogenic amine, precursor or metabolite thereof.

    Abstract translation: 本发明涉及分析化学，具体涉及定量测定衍生生物胺，其前体或其代谢物的手段和方法。 提供了在分离的含水样品中原位衍生至少一种生物胺，其前体或代谢物的方法，所述衍生包括以下步骤：（i）使所述样品与丙酸酐 /乙腈溶液在pH值为7.0-9.0的磷酸盐缓冲液存在下反应，并使所述生物胺或其代谢物的胺和/或羟基部分转化形成所述生物胺的丙酰基衍生物; 接着（ii）向步骤（i）中获得的反应混合物中加入碳化二亚胺化合物和含亲电子胺的化合物，并且允许碳二亚胺介导的生物胺，其前体或其代谢物的羧酸部分的衍生化。 p>

    MEANS AND METHODS FOR SUSTAINED OXYGEN RELEASE IN SITU
    5.
    发明申请
    MEANS AND METHODS FOR SUSTAINED OXYGEN RELEASE IN SITU 审中-公开
    用于持续的氧气释放的手段和方法

    公开(公告)号：WO2017039435A1

    公开(公告)日：2017-03-09

    申请号：PCT/NL2016/050595

    申请日：2016-08-26

    Applicant: RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN

    Inventor： BULSTRA, Sjoerd Klaas ,  STEG, Hilde ,  VELDHUIZEN, Albert Gerrit ,  KUIJER, Roelof

    IPC: A61L27/18 ,  A61L27/54 ,  A61K9/50

    CPC classification number: A61L27/18 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1641 ,  A61L27/54 ,  A61L2300/11 ,  C08L67/04

    Abstract: The invention relates to the field of tissue engineering and cell-based therapy. More in particular, it relates to an oxygen-releasing biomaterial that can enhance and support cell survival in vivo. Provided is an oxygen-delivering microsphere based on a biocompatible polymer, the microsphere comprising an agent capable of generating oxygen in situ encapsulated in a polymer matrix comprising poly (1,3-trimethylene carbonate) (PTMC). Also provided is an implantable device, like a scaffold for tissue engineering, comprising a plurality of oxygen-delivering microparticles according to the invention.

    Abstract translation: 本发明涉及组织工程和基于细胞的治疗领域。 更特别地，其涉及可以增强和支持体内细胞存活的释氧生物材料。 提供了基于生物相容性聚合物的输氧微球，所述微球包含能够产生原位包含在包含聚（1,3-三亚甲基碳酸酯）（PTMC）的聚合物基质中的氧的试剂。 还提供了可植入装置，如用于组织工程的支架，包括根据本发明的多个输氧微粒。

    METHOD AND SYSTEM FOR CONNECTING A LEAD TO CARDIAC TISSUE
    7.
    发明申请
    METHOD AND SYSTEM FOR CONNECTING A LEAD TO CARDIAC TISSUE 审中-公开
    将铅连接到心脏组织的方法和系统

    公开(公告)号：WO2016128071A1

    公开(公告)日：2016-08-18

    申请号：PCT/EP2015/053142

    申请日：2015-02-13

    Applicant: DEMCON ADVANCED MECHATRONICS B.V. ,  ACADEMISCH ZIEKENHUIS GRONINGEN

    Inventor： RUIJTER, Maria Cornelia ,  JACOBS, Hernes ,  LANSDORP, Benno ,  MARIANI, Massimo ,  KLINKENBERG, Theodorus Johannes

    IPC: A61N1/05 ,  A61B17/34 ,  A61N1/08 ,  A61B17/30 ,  A61B18/00

    CPC classification number: A61B17/3468 ,  A61B17/3421 ,  A61B18/1482 ,  A61B2017/003 ,  A61B2017/306 ,  A61B2017/3488 ,  A61B2018/00202 ,  A61B2018/00291 ,  A61B2018/00363 ,  A61B2018/00636 ,  A61B2018/00839 ,  A61B2018/00982 ,  A61N1/0587 ,  A61N2001/083

    Abstract: The invention relates to a method of connecting a lead to cardiac tissue in a patient's body, comprising the steps of: a) providing an elongated hollow delivery tool having a proximal end and a distal end, b) inserting the distal end of the tool into the patient's body, c) navigating the delivery tool until its distal end contacts the cardiac tissue at a contact location, d) determining if the contact location is suitable for connection of the lead, e) if the contact location is deemed suitable, fixedly connecting an electrode of the lead to the cardiac tissue at that location, and f) if the contact location is not deemed suitable, moving the distal end of the delivery tool away from the cardiac tissue and navigating the delivery tool until its distal end contacts the cardiac tissue at an alternative contact location that is spaced apart from the previous contact location, and repeating step d). The invention further relates to a system for connecting a lead to cardiac tissue in a patient's body, comprising: an elongated hollow delivery tool having a proximal end and a distal end, the distal end being arranged for insertion into the patient's body, a navigating device for navigating the distal end of the delivery tool to a contact location on the cardiac tissue, a determinator for determining the suitability of the contact location, and a connecting device for fixedly connecting an electrode of the lead to the cardiac tissue at a selected contact location.

    Abstract translation: 本发明涉及将导线连接到患者体内的心脏组织的方法，包括以下步骤：a）提供具有近端和远端的细长的中空递送工具，b）将所述工具的远端插入 患者的身体，c）导航输送工具，直到其远端在接触位置接触到心脏组织，d）确定接触位置是否适于连接引线，e）如果接触位置被认为合适，固定连接 导线的电极到该位置处的心脏组织，以及f）如果接触位置不被认为是合适的，则将输送工具的远端远离心脏组织移动并导航输送工具，直到其远端接触心脏 在与先前接触位置间隔开的替代接触位置处的组织，并重复步骤d）。 本发明还涉及一种用于将导线连接到患者体内的心脏组织的系统，包括：细长的中空输送工具，其具有近端和远端，所述远端布置成插入到患者体内，导航装置 用于将输送工具的远端导航到心脏组织上的接触位置，用于确定接触位置的适合性的确定器，以及用于将引线的电极固定地连接到所选择的接触位置处的心脏组织的连接装置 。

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