公开(公告)号：WO2004098498A3

公开(公告)日：2005-07-28

申请号：PCT/US2004012959

申请日：2004-04-28

Applicant: BAYER PHARMACEUTICALS CORP ,  MA XIN ,  CANTIN LOUIS-DAVID ,  CHOI SOONGYU ,  CLARK ROGER ,  HENTEMANN MARTIN ,  RUDOLPH JOACHIM ,  LAVOIE RICO ,  ZHANG ZHONGHUA

Inventor： MA XIN ,  CANTIN LOUIS-DAVID ,  CHOI SOONGYU ,  CLARK ROGER ,  HENTEMANN MARTIN ,  RUDOLPH JOACHIM ,  LAVOIE RICO ,  ZHANG ZHONGHUA

IPC: A61K20060101 ,  A61K31/405 ,  C07D209/08 ,  C07D209/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

CPC classification number: C07D403/12 ,  C07D209/08 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.

Abstract translation: 本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的用途。 本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。

公开(公告)号：WO2003027114A1

公开(公告)日：2003-04-03

申请号：PCT/US2002/030541

申请日：2002-09-24

Applicant: BAYER PHARMACEUTICALS CORPORATION ,  SMITH, Roger, A. ,  WONG, Wai, C. ,  O'CONNOR, Stephen, J. ,  CHOI, Soongyu ,  KLUENDER, Harold, C., E. ,  ZHANG, Zhonghua ,  LAVOIE, Rico, C. ,  FAN, Jianmei ,  PODLOGAR, Brent, L.

Inventor： SMITH, Roger, A. ,  WONG, Wai, C. ,  O'CONNOR, Stephen, J. ,  CHOI, Soongyu ,  KLUENDER, Harold, C., E. ,  ZHANG, Zhonghua ,  LAVOIE, Rico, C. ,  FAN, Jianmei ,  PODLOGAR, Brent, L.

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

Abstract translation: 本发明涉及已被发现抑制食欲并引起体重减轻的1,5,6,7-四氢吡咯并[3,2-c]吡啶衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。

公开(公告)号：WO2012173410A3

公开(公告)日：2013-03-28

申请号：PCT/KR2012004703

申请日：2012-06-14

Applicant: GREEN CROSS CORP ,  KIM MIN JU ,  LEE SUK HO ,  CHOI SOONGYU

Inventor： KIM MIN JU ,  LEE SUK HO ,  CHOI SOONGYU

IPC: A61K31/357 ,  A61K31/35 ,  A61P3/00 ,  A61P3/10 ,  C07D493/14

CPC classification number: C07D491/056 ,  C07D493/08

Abstract: The present invention relates to a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

Abstract translation: 本发明涉及一种对肠和肾中存在的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的新型C芳基ansa化合物及其作为活性成分的药物组合物，其可用于 预防或治疗代谢紊乱，特别是糖尿病。 本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。

公开(公告)号：WO2012165914A2

公开(公告)日：2012-12-06

申请号：PCT/KR2012/004366

申请日：2012-06-01

Applicant: GREEN CROSS CORPORATION ,  CHOI, Soongyu ,  SONG, Kwang-Seop ,  LEE, Suk Ho ,  KIM, Min Ju ,  SEO, Hee Jeong ,  PARK, Eun-Jung ,  KONG, Younggyu ,  PARK, So Ok ,  KANG, Hyunku ,  JUNG, Myung Eun ,  LEE, Kinam ,  KIM, Hyun Jung ,  LEE, Jun Sung ,  LEE, Min Woo ,  KIM, Mi-Soon ,  HONG, Dong Ho ,  KANG, Misuk

Inventor： CHOI, Soongyu ,  SONG, Kwang-Seop ,  LEE, Suk Ho ,  KIM, Min Ju ,  SEO, Hee Jeong ,  PARK, Eun-Jung ,  KONG, Younggyu ,  PARK, So Ok ,  KANG, Hyunku ,  JUNG, Myung Eun ,  LEE, Kinam ,  KIM, Hyun Jung ,  LEE, Jun Sung ,  LEE, Min Woo ,  KIM, Mi-Soon ,  HONG, Dong Ho ,  KANG, Misuk

IPC: A61K31/357 ,  A61K31/343 ,  A61K31/35 ,  A61K31/015 ,  A61P3/00

CPC classification number: C07D309/10 ,  C07D405/10 ,  C07D405/14 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D411/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

Abstract translation: 本发明涉及具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物和包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。 本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。

公开(公告)号：WO2010138758A1

公开(公告)日：2010-12-02

申请号：PCT/US2010/036467

申请日：2010-05-27

Applicant: PTC THERAPEUTICS, INC. ,  ALMSTEAD, Neil ,  ARASU, Tamil ,  CHOI, Soongyu ,  CAO, Liangxian ,  CAMPBELL, Jeff ,  CORSON, Don ,  DAVIS, Thomas, W. ,  GRACI, Jason, D. ,  GU, Zhengxian ,  HWANG, Peter, Seongwoo ,  LENNOX, William ,  MIAO, Harry, H. ,  MILLER, Langdon ,  MOON, Young-Choon ,  QI, Hongyan ,  TROTTA, Christopher ,  WEETALL, Marla, L.

Inventor： ALMSTEAD, Neil ,  ARASU, Tamil ,  CHOI, Soongyu ,  CAO, Liangxian ,  CAMPBELL, Jeff ,  CORSON, Don ,  DAVIS, Thomas, W. ,  GRACI, Jason, D. ,  GU, Zhengxian ,  HWANG, Peter, Seongwoo ,  LENNOX, William ,  MIAO, Harry, H. ,  MILLER, Langdon ,  MOON, Young-Choon ,  QI, Hongyan ,  TROTTA, Christopher ,  WEETALL, Marla, L.

IPC: A01N43/42 ,  A61K31/44

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4745 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/401 ,  Y02A50/463 ,  Y02A50/465

Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

Abstract translation: 描述了选择性抑制人血管内皮生长因子（VEGF）的病理生成的化合物和包含这些化合物的组合物。 描述了抑制病毒复制或产生病毒RNA或DNA或病毒蛋白的化合物和包含这些化合物的组合物。 还描述了使用这些化合物还原VEGF的方法以及用于治疗涉及施用这些化合物的癌症和非肿瘤性病症的方法。 进一步描述的是使用这种用于治疗涉及施用这些化合物的病毒感染的化合物和方法来抑制病毒复制或产生病毒RNA或DNA或病毒蛋白质的方法。 化合物可以作为单一药物治疗或与一种或多种另外的治疗组合施用于需要这种治疗的人。

公开(公告)号：WO2006058088A3

公开(公告)日：2006-06-01

申请号：PCT/US2005/042484

申请日：2005-11-23

Applicant: PTC THERAPEUTICS, INC. ,  CAO, Liangxian ,  CHOI, Soongyu ,  MOON, Young-choon ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  LENNOX, William Joseph ,  HWANG, Seongwoo

Inventor： CAO, Liangxian ,  CHOI, Soongyu ,  MOON, Young-choon ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  LENNOX, William Joseph ,  HWANG, Seongwoo

IPC: C07D209/88 ,  C07D495/04 ,  C07D317/66 ,  C07D209/94 ,  C07D261/14 ,  C07D213/82 ,  C07D498/22 ,  C07D271/10 ,  C07D285/06 ,  C07D487/22 ,  C07D307/84 ,  C07D307/68 ,  C07D333/38 ,  C07D263/32 ,  C07D239/42

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds and compositions useful in the inhibition of BEGF production, and/or in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

公开(公告)号：WO2005089764A1

公开(公告)日：2005-09-29

申请号：PCT/US2005/008481

申请日：2005-03-15

Applicant: PTC THERAPEUTICS, INC. ,  MOON, Young-Choon ,  CAO, Liangxian ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  CHOI, Soongyu ,  LENNOX, William Joseph ,  CORSON, Donald Thomas ,  HWANG, Seongwoo

Inventor： MOON, Young-Choon ,  CAO, Liangxian ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  CHOI, Soongyu ,  LENNOX, William Joseph ,  CORSON, Donald Thomas ,  HWANG, Seongwoo

IPC: A61K31/497

CPC classification number: A61K31/506 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  C07D471/04

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

Abstract translation: 根据本发明，已经鉴定了抑制转录后VEGF表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管生成和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。

公开(公告)号：WO2008127274A2

公开(公告)日：2008-10-23

申请号：PCT/US2007/020461

申请日：2007-09-21

Applicant: PTC THERAPEUTICS, INC. ,  CHOI, Soongyu ,  BRANSTROM, Arthur ,  GOTHE, Scott, A. ,  LIPMAN, Richard ,  TAMILARASU, Nadarajan ,  WILDE, Richard, G.

Inventor： CHOI, Soongyu ,  BRANSTROM, Arthur ,  GOTHE, Scott, A. ,  LIPMAN, Richard ,  TAMILARASU, Nadarajan ,  WILDE, Richard, G.

CPC classification number: C07D417/04 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D487/04

Abstract: Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for screening and identifying compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase. In particular, provided herein are assays for the identification of compounds that inhibit or reduce the activity of a bacterial peptidyl tRNA hydrolase. The methods provided herein provide a simple, sensitive assay for high- throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, and managing a bacterial infection or one or more symptoms thereof. Further provided herein are methods for preventing or inhibiting bacterial proliferation as well as methods for preventing, treating, and/or managing a bacterial infection using such compounds and compositions.

Abstract translation: 本文提供调节细菌肽基tRNA水解酶的活性的化合物，包括组合物和包含该化合物的剂型。 本文还提供了筛选和鉴定调节细菌肽基tRNA水解酶活性的化合物的方法。 特别地，本文提供了用于鉴定抑制或降低细菌肽基tRNA水解酶的活性的化合物的测定法。 本文提供的方法提供了用于化合物文库的高通量筛选的简单，灵敏的测定，以鉴定可用于预防，治疗和管理细菌感染或其一种或多种症状的药物引线。 本文还提供了用于预防或抑制细菌增殖的方法以及使用这些化合物和组合物预防，治疗和/或控制细菌感染的方法。

公开(公告)号：WO2006065479A3

公开(公告)日：2006-06-22

申请号：PCT/US2005/042482

申请日：2005-11-23

Applicant: PTC THERAPEUTICS, INC. ,  CHOI, Soongyu ,  MOON, Young-Choon ,  TAMILARASU, Nadarajan

Inventor： CHOI, Soongyu ,  MOON, Young-Choon ,  TAMILARASU, Nadarajan

IPC: A61K31/325 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/444 ,  A61K31/4523 ,  A61K31/472 ,  A61K31/496 ,  A61P35/00 ,  C07D211/66 ,  C07D243/08 ,  C07D209/08 ,  C07D215/20 ,  C07D401/12 ,  C07D491/10 ,  C07D217/24

Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.

公开(公告)号：WO2006065479A2

公开(公告)日：2006-06-22

申请号：PCT/US2005042482

申请日：2005-11-23

Applicant: PTC THERAPEUTICS INC ,  CHOI SOONGYU ,  MOON YOUNG-CHOON ,  TAMILARASU NADARAJAN

Inventor： CHOI SOONGYU ,  MOON YOUNG-CHOON ,  TAMILARASU NADARAJAN

IPC: C07D211/22 ,  A61K31/325 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/444 ,  A61K31/4523 ,  A61K31/472 ,  A61K31/496 ,  A61P35/00 ,  C07C271/44 ,  C07C271/58 ,  C07C311/08 ,  C07D209/08 ,  C07D211/60 ,  C07D211/66 ,  C07D215/08 ,  C07D215/20 ,  C07D217/06 ,  C07D217/24 ,  C07D243/08 ,  C07D295/20 ,  C07D401/12 ,  C07D471/04 ,  C07D491/10

CPC classification number: A61K31/403 ,  A61K31/343 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/424 ,  A61K31/4245 ,  A61K31/506 ,  A61K31/5377 ,  C07D209/08 ,  C07D209/90 ,  C07D471/04

Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.

Abstract translation: 本发明涉及用于抑制血管生成的方法，化合物和组合物。 更具体地说，本发明涉及用于抑制VEGF产生的方法，化合物和组合物。