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1.发明申请
公开(公告)号：WO2023283207A1
公开(公告)日：2023-01-12
申请号：PCT/US2022/036154
申请日：2022-07-05
IPC分类号： C07D307/68 , C07D307/46 , C07B41/12
摘要： An improved process and catalyst are provided for making an FDCA diester monomer product with improved productivity compared to an autocatalyzed esterification but with comparable or at least not greatly diminished color properties compared to the FDCA diester monomer product that would be produced autocatalytically, wherein a heterogeneous tin (II) catalyst is employed to make an esterification product comprising a diester of FDCA with an alcohol, the catalyst being in either a bulk, unsupported form or in the form of a supported tin (II) catalyst, in particular, using a hygroscopic support such as a gamma alumina, a zeolite or a silica, or using a carbon support.
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公开(公告)号：WO2022204080A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021254
申请日：2022-03-22
发明人： ECKELBARGER, Joseph, D. , HEEMSTRA, Ronald, J. , HUNTER, Ricky , KNUEPPEL, Daniel , MARTIN, Timothy, P. , TRULLINGER, Tony, K. , WALSH, Martin, J.
IPC分类号： C07C233/62 , C07D207/16 , C07D213/81 , C07D213/82 , C07D239/28 , C07D263/36 , C07D277/56 , C07D295/15 , C07D307/24 , C07D307/68 , A01N53/00
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).
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公开(公告)号：WO2022012963A1
公开(公告)日：2022-01-20
申请号：PCT/EP2021/068287
申请日：2021-07-02
IPC分类号： C07D307/68
摘要： Die vorliegende Erfindung betrifft 4-Furanamide der allgemeinen Formel (I) sowie ein Verfahren zur Herstellung von diesen Verbindungen und deren Verwendung als wichtige Vorstufen zur Synthese von agrochemischen und pharmazeutischen Wirkstoffen.
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公开(公告)号：WO2020157069A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052053
申请日：2020-01-28
申请人： NODTHERA LIMITED
IPC分类号： A61P3/10 , A61P17/10 , A61P25/28 , A61P29/00 , A61P35/00 , C07D239/42 , C07D249/14 , C07D251/22 , C07D261/18 , C07D263/48 , C07D271/113 , C07D277/56 , C07D307/68 , A61K31/341 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/4245 , A61K31/505 , A61K31/53 , A61K31/5377
摘要： The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory, and autoimmune diseases and cancers.
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公开(公告)号：WO2020051207A3
公开(公告)日：2020-03-12
申请号：PCT/US2019/049502
申请日：2019-09-04
IPC分类号： C07D213/74 , C07D237/20 , C07D239/24 , C07D239/42 , C07D239/48 , C07D239/84 , C07D251/46 , C07D251/48 , C07D253/065 , C07D277/42 , C07D277/82 , C07D295/205 , C07D307/52 , C07D307/68 , C07D401/04 , C07D417/12 , C07D475/08 , C07D487/04 , C07D487/12 , C07D495/04 , C07D513/04 , C07D249/06 , C07D257/04 , C07D401/12 , C07D403/10 , C07D405/04 , C07D413/04 , C07D413/14 , A61P35/00 , A61K31/519 , A61P7/00
摘要： The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.
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公开(公告)号：WO2020051207A2
公开(公告)日：2020-03-12
申请号：PCT/US2019/049502
申请日：2019-09-04
IPC分类号： C07D213/74 , C07D237/20 , C07D239/24 , C07D239/42 , C07D239/48 , C07D239/84 , C07D251/46 , C07D251/48 , C07D253/065 , C07D277/42 , C07D277/82 , C07D295/205 , C07D307/52 , C07D307/68 , C07D401/04 , C07D417/12 , C07D475/08 , C07D487/04 , C07D487/12 , C07D495/04 , C07D513/04 , C07D249/06 , C07D257/04 , C07D401/12 , C07D403/10 , C07D405/04 , C07D413/04 , C07D413/14 , A61P35/00 , A61K31/519 , A61P7/00
摘要： The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.
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公开(公告)号：WO2020005607A1
公开(公告)日：2020-01-02
申请号：PCT/US2019/037427
申请日：2019-06-17
IPC分类号： C07D307/68
摘要： Disclosed herein is a very efficient method to make 5- (alkoxycarbonyl)furan-2-carboxylic acids (ACFC) from feedstocks comprised of furoates. When a feedstock comprised of methyl 5-methylfuran-2- carboxylate (MMFC) is used a product comprised of (5- (methoxycarbonyl)furan-2-carboxylic acid (MCFC) is obtained in high yield.
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8.发明申请
公开(公告)号：WO2019199570A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/025785
申请日：2019-04-04
发明人： BRAZDIL, James , ROGNESS, Donald
IPC分类号： C07D307/68
摘要： Processes are disclosed for the synthesis of 2-substituted furan derivatives from a substrate having a carbonyl functional group (C=O), with hydroxy-substituted carbon atoms at alpha and beta positions, relative to the carbonyl functional group. In one embodiment, an alpha-, beta-dihydroxy carboxylate is dehydrated to form a dicarbonyl intermediate by transformation of the alpha-hydroxy group to a second carbonyl group and removal of the beta-hydroxy group. The dicarbonyl intermediate undergoes cyclization and dehydration to produce the 2-substituted furan derivative. Optionally, a further step of oxidation may be carried out, for example to convert a hydroxymethyl group, as a 5-substituted furan ring, to a carboxy group of 2,5-furan dicarboxylic acid.
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公开(公告)号：WO2019185646A3
公开(公告)日：2019-10-03
申请号：PCT/EP2019/057617
申请日：2019-03-26
发明人： MINES, Paul , LAW, Paul , CARNELL, Andrew , MCKENNA, Shane , BLACKER, John , KAPUR, Nikil
IPC分类号： C12P17/04 , C12M1/40 , C12M1/24 , C07D307/50 , C07D307/68 , B01J14/00 , C08G63/181 , B01F5/06 , B01F5/04 , B01F13/00 , B01F3/08 , C12P7/44
摘要： A process for oxidising a substrate selected from hydroxymethylfurfural (HMF), diformylfuran (DFF), hydroxymethylfurancarboxylic acid (HMFCA) and formylfurancarboxylic acid (FFCA). Said process comprises mixing said substrate with catalase, one or more further enzymes and hydrogen peroxide to form a reaction mixture. Said one or more further enzymes have the ability to catalyse oxidation of said substrate. Said hydrogen peroxide is provided at a total molar ratio of at least about 0.1:1 hydrogen peroxide to substrate.
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公开(公告)号：WO2019132663A1
公开(公告)日：2019-07-04
申请号：PCT/NL2018/050894
申请日：2018-12-31
发明人： ENGEL, Carol Andrea Roa , VAN DER MEER, Johannes , GEERS, Leonard Ferdinand Gerard , CROCKATT, Marc
IPC分类号： C07D307/68
摘要： The invention is based on the finding that when conducting crystallization of FDCA at high temperatures, the formation of significant amounts of colored byproduct can be reduced or even avoided when the FDCA mixture is kept at temperatures above 100 °C for less than 15 minutes. This is achieved by conducting the crystallization process in a continuous reactor. Accordingly, the method comprises the steps of feeding a mixture comprising undissolved FDCA and a solvent to a reactor; and dissolving FDCA by superheating the mixture in the reactor to a temperature of at least 130 °C; and crystallizing FDCA by cooling the mixture in the reactor, wherein the reactor is a continuous reactor and the residence time in the reactor zone wherein the FDCA mixture has a temperature above 100 °C is less than 15 minutes.
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