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    POLYMERIC LABEL MOLECULES
    3.
    发明申请
    POLYMERIC LABEL MOLECULES 审中-公开
    聚合物标签分子

    公开(公告)号：WO03106637A2

    公开(公告)日：2003-12-24

    申请号：PCT/US0318768

    申请日：2003-06-12

    Applicant: DATASCOPE INVESTMENT CORP ,  ZAK S ARIEH ,  KADUSHIN JAMES M ,  GETTS ROBERT C ,  REINHARDT JASON ,  GETTS LORI

    Inventor： ZAK S ARIEH ,  KADUSHIN JAMES M ,  GETTS ROBERT C ,  REINHARDT JASON ,  GETTS LORI

    IPC: C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  C12N

    CPC classification number: C12Q1/682 ,  C12Q1/6813 ,  C12Q2533/107

    Abstract: A method of constructing a highly labeled linear polymeric molecule for use in any desired application, and linear polymeric molecules of such structure. The polymeric molecule is a nucleic acid constructed from a large number of one or more types of monomeric oligonucleotide units that are attached together to form an extended strand. Within each polymer, at least one type of monomeric unit is provided which is bound to or designed to bind to a label moiety, providing a polymer with a large number of repeat sequences designed for labeling purposes, resulting in extremely effective signal carrying molecule of considerable versatility.

    Abstract translation: 构建用于任何所需应用的高度标记的线性聚合物分子的方法，以及这种结构的线性聚合物分子。 聚合物分子是由大量一种或多种类型的单体寡核苷酸单元构成的核酸，其连接在一起以形成延伸的链。 在每个聚合物中，提供至少一种类型的单体单元，其结合或设计成结合标记部分，提供具有大量设计用于标记目的的重复序列的聚合物，导致极其有效的信号携带分子 多功能性。

    DOCKING STATION FOR A TRANSPORTABLE DEVICE
    4.
    发明申请
    DOCKING STATION FOR A TRANSPORTABLE DEVICE 审中-公开

    公开(公告)号：WO2003024301A3

    公开(公告)日：2003-03-27

    申请号：PCT/US2002/029321

    申请日：2002-09-16

    Applicant: DATASCOPE INVESTMENT CORP. ,  KAUSHANSKY, Yefim ,  PACENKA, Edmund, G.

    Inventor： KAUSHANSKY, Yefim ,  PACENKA, Edmund, G.

    IPC: A61M1/10

    Abstract: A mounting device (10) for securing transport patient connected equipment, specifically an intra-aortic balloon pump (IABP) (22), in the typically crowded medical transport vehicle. An engagement stud (20) on the IABP (22) slides into a spring-loaded latch (40) connected to a vehicle mounted base (11). The engagement stud configuration allows the user to engage the IABP (22) from any desired direction, i.e. slide the pump (22) from any of the four sides onto the mount (11). No effort is required from the user beyond the pushing motion for locking the IABP (22) onto the mount (11).

    METHODS FOR BLOCKING NONSPECIFIC HYBRIDIZATIONS OF NUCLEIC ACID SEQUENCES
    5.
    发明申请
    METHODS FOR BLOCKING NONSPECIFIC HYBRIDIZATIONS OF NUCLEIC ACID SEQUENCES 审中-公开

    公开(公告)号：WO2003020902A3

    公开(公告)日：2003-03-13

    申请号：PCT/US2002/027799

    申请日：2002-09-03

    Applicant: DATASCOPE INVESTMENT CORP. ,  KADUSHIN, James, M. ,  GETTS, Robert, C. ,  ZAK, Arieh, S.

    Inventor： KADUSHIN, James, M. ,  GETTS, Robert, C. ,  ZAK, Arieh, S.

    IPC: C12Q1/68

    Abstract: Methods are provided for blocking non-specific and specific hybridization of nucleic acid samples on a microarray. The method of the present invention comprises applying a blocking reagent to the microarray, wherein the blocking reagent comprises modified nucleotide bases, preferably LNA (Locked Nucleic Acid -modified bicyclic monomeric units with a 2'-0- 4'-C methylene bridge). In further embodiments, the method includes applying a mixture including: a) a cDNA reagent obtained from mRNA of a target sample, the cDNA having a capture sequence; b) a dendrimer with a label for emitting a detectable signal and a second nucleotide sequence complementary to the capture sequence; and c) an blocking reagent containing LNA to a microarray, for producing a detectable signal from said label whereby a hybridization pattern is generated on the microarray.

    METHODS FOR BLOCKING NONSPECIFIC HYBRIDIZATIONS OF NUCLEIC ACID SEQUENCES
    6.
    发明申请
    METHODS FOR BLOCKING NONSPECIFIC HYBRIDIZATIONS OF NUCLEIC ACID SEQUENCES 审中-公开
    阻断核酸序列非特异性杂交的方法

    公开(公告)号：WO2003020902A2

    公开(公告)日：2003-03-13

    申请号：PCT/US2002/027799

    申请日：2002-09-03

    Applicant: DATASCOPE INVESTMENT CORP. ,  KADUSHIN, James, M. ,  GETTS, Robert, C. ,  ZAK, Arieh, S.

    Inventor： KADUSHIN, James, M. ,  GETTS, Robert, C. ,  ZAK, Arieh, S.

    IPC: C12N

    CPC classification number: C12Q1/6832 ,  C12Q1/6837 ,  C12Q2565/501 ,  C12Q2549/126 ,  C12Q2525/186 ,  C12Q2525/113

    Abstract: Methods are provided for blocking non-specific and specific hybridization of nucleic acid samples on a microarray. The method of the present invention comprises applying a blocking reagent to the microarray, wherein the blocking reagent comprises modified nucleotide bases, preferably LNA (Locked Nucleic Acid -modified bicyclic monomeric units with a 2'-0- 4'-C methylene bridge). In further embodiments, the method includes applying a mixture including: a) a cDNA reagent obtained from mRNA of a target sample, the cDNA having a capture sequence; b) a dendrimer with a label for emitting a detectable signal and a second nucleotide sequence complementary to the capture sequence; and c) an blocking reagent containing LNA to a microarray, for producing a detectable signal from said label whereby a hybridization pattern is generated on the microarray.

    Abstract translation: 提供了用于阻断核酸样品在微阵列上的非特异性和特异性杂交的方法。 本发明的方法包括向微阵列施加封闭试剂，其中所述封闭试剂包含修饰的核苷酸碱基，优选LNA（具有2'-0-4'-C亚甲基桥的锁定核酸修饰的双环单体单元）。 在另外的实施方案中，所述方法包括施加混合物，所述混合物包括：a）从靶样品的mRNA获得的cDNA试剂，所述cDNA具有捕获序列; b）具有用于发射可检测信号的标记的树枝状大分子和与捕获序列互补的第二核苷酸序列; 和c）含有LNA至微阵列的封闭试剂，用于从所述标记产生可检测信号，从而在微阵列上产生杂交图谱。

    VASCULAR HEMOSTASIS DEVICE AND DEPLOYMENT APPARATUS
    9.
    发明申请
    VASCULAR HEMOSTASIS DEVICE AND DEPLOYMENT APPARATUS 审中-公开
    血管造影装置和部署装置

    公开(公告)号：WO2008121192A1

    公开(公告)日：2008-10-09

    申请号：PCT/US2008/002442

    申请日：2008-02-25

    Applicant: DATASCOPE INVESTMENT CORP. ,  BATES, James, S. ,  HINCHLIFFE, Peter

    Inventor： BATES, James, S. ,  HINCHLIFFE, Peter

    IPC: A61B17/08 ,  A61D1/00

    CPC classification number: A61B17/0057 ,  A61B2017/00407 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659

    Abstract: A hemostasis device (30) for percutaneously sealing a puncture (14) in the wall of a blood vessel (16) includes a rigid post (40), and a foot (60), a seal (80) and a retaining member (100) mounted on the rigid post. The hemostasis device may be deployed in the puncture so that the foot is positioned within the blood vessel. Tension is applied to the rigid post to hold the foot against the inside surface of the blood vessel. The retaining member is then pushed along the length of the rigid post, advancing the seal to a deployed state against the outside surface of the blood vessel. The puncture in the blood vessel is sandwiched between the foot and the seal in the deployed state. The rigid post, foot, seal and retaining member may all be formed from a resorbable polymeric material.

    Abstract translation: 用于在血管（16）的壁中经皮密封穿刺（14）的止血装置（30）包括刚性柱（40）和脚（60），密封件（80）和保持构件（100） ）安装在刚性柱上。 止血装置可以部署在穿刺中，使得脚定位在血管内。 对刚性柱施加张力以将脚保持抵靠血管的内表面。 然后沿着刚性柱的长度推动保持构件，使密封件朝向血管的外表面展开到展开状态。 在展开状态下，血管中的穿刺被夹在脚和密封件之间。 刚性柱，脚，密封和保持构件都可以由可再吸收的聚合物材料形成。

    SURGICAL STAPLING SYSTEM
    10.
    发明申请
    SURGICAL STAPLING SYSTEM 审中-公开
    外科手术系统

    公开(公告)号：WO2005115254A2

    公开(公告)日：2005-12-08

    申请号：PCT/US2005/017211

    申请日：2005-05-17

    Applicant: DATASCOPE INVESTMENT CORP. ,  FONTAYNE, Diego, Y. ,  SEMLER, Mark

    Inventor： FONTAYNE, Diego, Y. ,  SEMLER, Mark

    IPC: A61B17/04

    CPC classification number: A61B17/115 ,  A61B17/072 ,  A61B17/1155 ,  A61B17/12013 ,  A61B2017/1107 ,  A61B2017/1157 ,  A61F2/06 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/9517

    Abstract: A system is provided for joining two tubular structures by a surgical stapling procedure. The system includes a series of sizers (900), a specifically designed graft (10, 50), a loading unit (100) , a wand (300) , a surgical loop (400) and a stapling instrument (500). The sizers are for determining the diameter of a target aorta and the availability of a sufficient transected aortic length to perform a stapling procedure. The loading unit holds the graft in position in the body and deploys a circumferential line of staples (150) through the graft and an overlapping end of the aorta. The graft may include a side port (20) by which the loading unit holds the graft during the stapling procedure, and which may be closed once the stapling procedure has been completed. The wand may be used to introduce the loading unit and graft into the body, to position them within the transected aorta, and to hold them in place during the application of the surgical loop. The surgical loop may include a band (416) formed from a flexible material and having a width greater than its thickness so as to facilitate the formation of an annular loop. With the surgical loop holding the aorta and graft in relative overlapping positions, the wand may be removed from the loading unit and the stapling instrument may be assembled thereto. The stapling instrument includes a plurality of anvils (518a, 518b, 518c) which may be closed to form a circle overlying the aorta, and a trigger mechanism (670, 802) for firing the staples. When fired, the staples are deployed radially outward through the graft and aorta, whereupon their free ends are bent inwardly by staple returns (528) on the anvils. As a result, a plurality of staples may be simultaneously deployed quickly and accurately in a circumferential pattern so as to join together two tubular structures. The system may be used in either an open surgical procedure or laparascopically.

    Abstract translation: 提供了一种通过外科缝合程序连接两个管状结构的系统。 该系统包括一系列的筛分器（900），专门设计的移植物（10,50），加载单元（100），棒（300），手术回路（400）和吻合器械（500）。 筛分器用于确定目标主动脉的直径以及有足够横切的主动脉长度以执行吻合程序。 装载单元将移植物保持在体内的适当位置并且通过移植物和主动脉的重叠端部署周向的缝合线（150）。 移植物可以包括侧端口（20），装订单元在缝合过程期间保持移植物，并且一旦吻合程序完成就可以关闭。 可以使用魔杖将装载单元和移植物引入体内，将其定位在横切的主动脉内，并且在手术环路的应用期间将其保持在适当的位置。 手术环可以包括由柔性材料形成并具有大于其厚度的宽度的带（416），以便于形成环形环。 当外科手术环将主动脉和移植物保持在相对重叠的位置时，可以从装载单元移除魔杖，并且装订器械可以组装到其上。 缝合器械包括多个砧座（518a，518b，518c），其可以被封闭以形成覆盖主动脉的圆圈，以及用于触发钉钉的触发机构（670,802）。 当被发射时，缝钉通过移植物和主动脉径向向外展开，于是它们的自由端通过砧座上的缝合返回（528）向内弯曲。 结果，可以以圆周图案快速且准确地同时展开多个钉，以便将两个管状结构连接在一起。 该系统可以用于开放式外科手术或laparascopically。

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