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    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
    2.
    发明申请
    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF 审中-公开

    公开(公告)号：WO2017007796A4

    公开(公告)日：2017-01-12

    申请号：PCT/US2016/041055

    申请日：2016-07-06

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： ANDREEV, Julian ,  THAMBI, Nithya ,  DELFINO, Frank ,  MARTIN, Joel ,  THURSTON, Gavin ,  CYGNAR, Katherine ,  PAPADOPOULOS, Nicholas

    IPC: C07K16/28 ,  C07K16/46 ,  C07K16/22 ,  C07K16/12 ,  C07K16/32 ,  C07K16/18 ,  C07K14/435 ,  A61K47/48

    Abstract: The present disclosure provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present disclosure can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the disclosure, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present disclosure results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the disclosure, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present disclosure causes or facilitates the targeted killing of tumor cells.

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