TEMPERATURE-CONTROLLED CONTAINER SYSTEMS FOR USE WITHIN A REFRIGERATION DEVICE
    6.
    发明申请
    TEMPERATURE-CONTROLLED CONTAINER SYSTEMS FOR USE WITHIN A REFRIGERATION DEVICE 审中-公开
    在制冷装置中使用的温度控制容器系统

    公开(公告)号:WO2015081057A1

    公开(公告)日:2015-06-04

    申请号:PCT/US2014/067273

    申请日:2014-11-25

    Applicant: TOKITAE LLC

    Abstract: In some embodiments, a temperature-controlled container for use within a refrigeration device includes: one or more sections of insulation material substantially defining one or more walls of a temperature-controlled container, the temperature-controlled container including an internal region; a thermally-insulated partition dividing the internal region to form a storage region and a phase change material region internal to the container, the thermally-insulated partition including a conduit between the storage region and the phase change material region; a thermal control device within the conduit; an aperture within a section of the insulation material substantially defining the container, the aperture between the phase change material region internal to the container and an external surface of the container; and a unidirectional thermal conductor positioned within the aperture, the unidirectional thermal conductor configured to transmit heat in a direction from the phase change material region to the external surface of the container.

    Abstract translation: 在一些实施例中,用于制冷装置内的温度控制容器包括:绝热材料的一个或多个部分,基本上限定温度控制容器的一个或多个壁,所述温度控制容器包括内部区域; 分隔所述内部区域以形成容器内部的存储区域和相变材料区域的绝热隔板,所述绝热隔板包括在所述存储区域和所述相变材料区域之间的导管; 管道内的热控制装置; 基本上限定容器的绝缘材料的一部分内的孔,容器内部的相变材料区域和容器的外表面之间的孔; 以及定位在所述孔内的单向热导体,所述单向热导体构造成在从所述相变材料区域到所述容器的外表面的方向上传递热量。

    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS
    8.
    发明申请
    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 审中-公开
    包括温度控制容器系统的制冷装置

    公开(公告)号:WO2016179215A1

    公开(公告)日:2016-11-10

    申请号:PCT/US2016/030658

    申请日:2016-05-04

    Applicant: TOKITAE LLC

    CPC classification number: F25D16/00 F25B23/006 F25D11/006

    Abstract: In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

    Abstract translation: 在一些实施例中,制冷装置包括:基本上形成液体不可渗透容器的壁,其构造成将相变材料保持在制冷装置内部; 至少一个主动制冷单元,其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统,其包括具有中空内部的第一组不透气结构,以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器,具有中空内部连接的第二组蒸气不可渗透结构 以形成与基本上形成存储区域的壁热接触的蒸发器,以及具有固定到冷凝器和蒸发器两者的中空内部的连接器,所述连接器在冷凝器的中空内部和所述冷凝器之间形成液体和蒸气流动路径 中空的蒸发器内部。

    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS
    9.
    发明申请
    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
    微型或三维印刷的流感疫苗制剂

    公开(公告)号:WO2015095230A1

    公开(公告)日:2015-06-25

    申请号:PCT/US2014/070664

    申请日:2014-12-16

    Abstract: Emulsion-based and micromolded ("MM") or three dimensional printed ("3DP") polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

    Abstract translation: 已经开发了用于单次注射抗原的乳液基和微成型(“MM”)或三维印刷(“3DP”)聚合物制剂,优选在两个或更多个时间段内释放。 制剂优选由生物相容的可生物降解的聚合物形成。 单独或与其他抗原,佐剂,稳定剂和释放调节剂组合的包封抗原的离散区域存在于制剂中。 抗原优选在给药时或赋形剂的表面存在于赋形剂中,用于立即释放,并且在初始释放抗原后10至45天,任选地以10至90天的间隔,并入引发至制剂内以释放 在一个或多个额外的时间段内释放抗原。 抗原可以通过使用稳定剂例如海藻糖玻璃来稳定。 在用于针对脊髓灰质炎免疫的优选实施方案中,抗原在给药时释放,此后二,四和六个月释放。

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