公开(公告)号：WO2023082005A1

公开(公告)日：2023-05-19

申请号：PCT/CA2022/051661

申请日：2022-11-10

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： VON DER ECKEN, Sebastian ,  WHEELER, Aaron R. ,  CHAMBERLAIN, Michael Dean ,  SKLAVOUNOS, Alexandros

IPC: B81B1/00 ,  B81B7/04 ,  H01L23/48 ,  H01L31/08 ,  H05K1/16

Abstract: A microfluidics device comprises a cover mounted to an addressing structure. The cover has a working surface on one side, and a plurality of electrodes on its other side. The electrodes may be used for manipulation of fluid droplets on the working surface. The electrodes are connected to a voltage source by way of the addressing structure to selectively apply voltage to individual ones of the plurality of electrodes.

公开(公告)号：WO2022243780A1

公开(公告)日：2022-11-24

申请号：PCT/IB2022/054242

申请日：2022-05-07

Applicant: COOLIT SYSTEMS, INC.

Inventor： MOSTAFAVI YAZDI, Seyed Kamaleddin ,  MUTLOW, Sean ,  GOULD, Robert

IPC: F28F9/26 ,  B81B1/00 ,  F25D31/00 ,  F28F3/08 ,  F28F9/00 ,  H01L23/46 ,  H05K7/20

Abstract: A modular heat exchange assembly includes a cold plate defining a finned surface and a corresponding plurality of microchannels. Selected ones of the plurality of microchannel extend from a first end to an opposed second end. A fluid receiver unit defines an inlet port and a first fluid connector fluidically coupled with the inlet port. A fluid transfer unit defines an outlet port and a second fluid connector matingly engageable with and disengageable from the first fluid connector to fluidly couple the fluid receiver unit and the fluid transfer unit together. The fluid transfer unit defines a distribution manifold configured to distribute coolant among the selected microchannels at a position between the first ends and the second ends of the selected microchannels. The fluid transfer unit further defines a collection manifold configured to receive coolant from the selected microchannels. The collection manifold and the outlet port are fluidically coupled together.

公开(公告)号：WO2022216275A1

公开(公告)日：2022-10-13

申请号：PCT/US2021/025896

申请日：2021-04-06

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： DENISON, Carson ,  KORNILOVICH, Pavel ,  SEAVER, Richard W. ,  JEBAKUMAR, Anand Samuel ,  TORNIANEN, Erik D. ,  GOVYADINOV, Alexander

IPC: C12Q1/6806 ,  G01N33/569 ,  B01F3/08 ,  B81B1/00

Abstract: A microfluidic device includes a first channel, second channels, and a transition channel splitting the first channel into the second channels. The transition has a first end fluidically connected to the first channel and a second end fluidically connected to the second channels. The transition channel expands in width from a width of the first channel at the first end to no less than a sum of widths of the second channels at the second end so as to promote fluid flow from the first channel to the second channels.

公开(公告)号：WO2022216274A1

公开(公告)日：2022-10-13

申请号：PCT/US2021/025889

申请日：2021-04-06

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： TORNIANEN, Erik D. ,  DENISON, Carson ,  SEAVER, Richard W. ,  JEBAKUMAR, Anand Samuel ,  KORNILOVICH, Pavel ,  GOVYADINOV, Alexander

IPC: B81B1/00 ,  B81B7/00 ,  F15C1/06 ,  F15D1/02

Abstract: A microfluidic device includes a first channel having a first width and a second channel having a second width greater than the first width. The microfluidic device includes a transition channel having a first end fluidically connected to the first channel and a second end fluidically connected to the second channel. The transition channel expands in width from the first width to the second width so as to promote fluid flow from the first channel to the second channel.

公开(公告)号：WO2022192683A1

公开(公告)日：2022-09-15

申请号：PCT/US2022/019971

申请日：2022-03-11

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： CHENG, Jiangtao ,  HE, Xukun

IPC: B81B1/00

Abstract: This disclosure provides an apparatus, including a first plate having a first transport surface and a second plate having a second transport surface. The second plate is positioned at an acute angle with respect to the first plate such that a first transport surface of the first plate faces the second transport surface of the second plate. The first transport surface and the second transport surface are hydrophobic. The apparatus also includes one or more liquid droplets positioned between and in contact with the first transport surface and the second transport surface. During evaporation, the liquid droplet will automatically move towards the cusp of the first plate and the second plate.

公开(公告)号：WO2022177558A1

公开(公告)日：2022-08-25

申请号：PCT/US2021/018412

申请日：2021-02-17

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： SHKOLNIKOV, Viktor ,  GOVYADINOV, Alexander

IPC: B81B1/00 ,  B81B7/02 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/64 ,  C12M1/02 ,  C12M1/38

Abstract: The present disclosure is drawn to microfluidic nucleic acid amplification systems. The systems can include a microfluidic device and a chamber particle. The microfluidic device can include a microfluidic amplification region and a heating element positioned to heat and directly interface with a fluid when present in the microfluidic amplification region. The chamber particle can have an external diameter of from about 10 µm to about 200 µm and can include chamber particle walls with dried reagent associated therewith. The chamber particle walls can define a chamber therein that can be sized to allow a plurality of nucleic acid molecules to enter the chamber.

公开(公告)号：WO2022159097A1

公开(公告)日：2022-07-28

申请号：PCT/US2021/014591

申请日：2021-01-22

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： DENISON, Carson ,  TORNIAINEN, Erik D. ,  SEAVER, Richard W. ,  KORNILOVICH, Pavel ,  GOVYADINOV, Alexander ,  JEBAKUMAR, Anand Samuel

IPC: C12M1/00 ,  C12M3/06 ,  B81B1/00

Abstract: A microfluidic device includes a chamber having sidewalls, a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has an orientation relative to the inlet defined by a leading surface and a trailing corner opposite the leading corner. The trailing corner has an angle less than a threshold angle that is based on a fluidic contact angle. The orientations of the pillars relative to the inlet promote fluid flow from the inlet throughout the chamber without trapping gas at the sidewalls of the chamber.

公开(公告)号：WO2022147426A1

公开(公告)日：2022-07-07

申请号：PCT/US2021/073114

申请日：2021-12-27

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： MITCHELL, Michael J. ,  ISSADORE, David Aaron ,  YADAVALI, Sagar Prasad ,  SHEPHERD, Sarah J.

IPC: B81B1/00 ,  B81B7/04

Abstract: Provided are scalable, parallelized microfluidic chips that include arrays of microfluidic mixing channels for large-scale production of lipid nanoparticles, among other products. The disclosed chips can operate with a single set of inlets and outlet, and achieve production rates in excess of those achieved by existing methods. The disclosed devices provide large-scale production of formulations while still maintaining the physical properties and potency typical of existing methods of producing such formulations. Also provided are related methods of using the disclosed devices.

公开(公告)号：WO2022125074A1

公开(公告)日：2022-06-16

申请号：PCT/US2020/063756

申请日：2020-12-08

Applicant: HP HEALTH SOLUTIONS INC. [US]/[US]

Inventor： LAHMANN, John Michael ,  FAASE, Kenneth James ,  HAINES, Paul Mark

IPC: G01N1/28 ,  B81B1/00 ,  C12Q1/6806 ,  C12Q1/6809 ,  G01N33/487

Abstract: A fluidic device can include interconnected volumes including a bulk fluid volume fluidically connected in series with a capillary volume to receive a density gradient column, a reservoir of a non-newtonian plugging fluid positioned outside the interconnected volumes, and a plugging fluid injection opening positioned at a location along a length of the interconnected volumes to inject the non-newtonian plugging fluid therein. The non-newtonian plugging fluid can have a sufficient viscosity to partition fluid upstream of the non-newtonian plugging fluid from fluid downstream of the non-newtonian plugging fluid.

公开(公告)号：WO2022109113A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/059856

申请日：2021-11-18

Applicant: CELLFE, INC.

Inventor： HAN, Sewoon ,  SICHER, Ian ,  ALEXEEV, Alexander ,  KIM, Ockchul

IPC: C12M3/00 ,  C12N5/071 ,  B81B1/00 ,  B01L3/00

Abstract: Described herein are methods and systems for mechanoporation-based high-throughput payload delivery into biological cells. For example, one system can process at least 1 billion cells per minute or at least 25 billion cells per minute, which is substantially greater than conventional methods. A cell processing apparatus comprises a processing assembly formed by stacking multiple processing components. Each processing component comprises channels, which may be used for filtration, mechanoporation, and/or separation of cells in the cell media. This functionality depends on the configuration of each channel. For example, each channel comprises one or more ridges such that each ridge forms a processing gap with an adjacent one of the processing components. The ridges may extend to the side walls or form a bypass gap with the wall. The processing gaps can be specially configured to compress cells as the cells pass through these gaps thereby initiating the mechanoporation process.