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    NOVEL CAPSAICIN ANALOGS AND USES THEREOF
    1.
    发明申请
    NOVEL CAPSAICIN ANALOGS AND USES THEREOF 审中-公开

    公开(公告)号：WO2022099284A1

    公开(公告)日：2022-05-12

    申请号：PCT/US2021/072234

    申请日：2021-11-04

    Applicant: YOUNG BIOPHARMA, LLC

    Inventor： SHEN, Young ,  LIU, Junke

    IPC: A61K31/05 ,  A61K31/327 ,  C07C215/46 ,  C07C409/00 ,  C07C409/40

    Abstract: The present invention provides compositions comprising compounds having formulas (I), (II) or (III): and additionally provides methods for the use thereof in the treatment of various disorders including neurological disorders, cancer, diabetes, and obesity, wherein R1-R7, X, A, and Q in (I), R1-R15 in (II) and R1-R15 in (III) are as defined herein. In certain embodiments, methods for the treatment of various disorders including pain and cancer comprise topically, locally or systemically (e.g., IV, IP or orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formulas (I), (II) or (III).

    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM
    3.
    发明申请
    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM 审中-公开
    通过形成和利用液相薄膜氧化烃的非大气压方法

    公开(公告)号：WO2011053818A3

    公开(公告)日：2011-09-22

    申请号：PCT/US2010054788

    申请日：2010-10-29

    Applicant: ILLA INTERNATIONAL LLC ,  ZAKOSHANSKY VLADIMIR

    Inventor： ZAKOSHANSKY VLADIMIR

    IPC: B01J10/00 ,  C07C407/00 ,  C07C409/00

    CPC classification number: B01J10/02 ,  B01J10/002 ,  B01J2219/0004 ,  C07C407/00 ,  C07C409/02 ,  C07C409/08 ,  C07C409/10 ,  C07C409/12

    Abstract: The purpose of the present invention is to provide an advantageous non-barbotage method for oxidation of aromatic hydrocarbons, that, when implemented in various embodiments thereof, provides significantly higher selectivity, a greater level of safety, Sower capital costs, etc., than conventional oxidation processes utilizing the barbotage technique. The essence of the inventive non-barbotage oxidation process is ensuring that the oxidizing agent delivered to the process reactor undergoes continued contact only with exposed surfaces of the liquid phase of the hydrocarbons being oxidized configured as at least one of: formed liquid phase thin film(s), liquid phase continuous stream(s), and/or liquid phase globule (e.g., droplets, etc.) stream(s), preferably, with the surface area(s) of the exposed surface(s) being maximized to increase contact with an oxidizing agent being directed thereto, to ensure that the inventive oxidation reaction occurs at the border between liquid and gas phases, such that the oxidation reaction effectively occurs by way of contact of the oxidizing agent (e.g., oxygen) from the gas phase with exposed surface(s) of the liquid phase of the hydrocarbons being oxidized. The inventive non-barbotage oxidation process may be implemented in a single reactor, or in plural sequential reactors, and may be implemented both in a stand-alone configuration, and in combination with various conventional barbotage methods for oxidation of aromatic hydrocarbons.

    Abstract translation: 本发明的目的是提供用于芳族烃氧化的有利的非阻塞方法，当其在各种实施方案中实施时，与常规方法相比，提供了显着更高的选择性，更高的安全性水平，更低的资金成本等 利用barbotage技术的氧化过程。 本发明的非强制氧化工艺的实质是确保输送到工艺反应器的氧化剂仅与被氧化的烃的液相的暴露表面连续接触，所述暴露表面被配置为形成的液相薄膜（ s），液相连续流和/或液相小球（例如液滴等）流，优选地使暴露表面的表面积最大化以增加 与导向其的氧化剂接触，以确保本发明的氧化反应发生在液相和气相之间的边界，使得氧化反应通过氧化剂（例如氧气）与气相接触而有效地发生 烃的液相的暴露表面被氧化。 本发明的非破坏氧化过程可以在单个反应器中或在多个连续反应器中实施，并且可以以独立构造实施并且与用于氧化芳香烃的各种常规破碎方法结合实施。

    PEROXIDE BLEND COMPOSITIONS AND METHODS FOR CURING POLYESTER RESINS
    5.
    发明申请
    PEROXIDE BLEND COMPOSITIONS AND METHODS FOR CURING POLYESTER RESINS 审中-公开
    过氧化物混合组合物和固化聚酯树脂的方法

    公开(公告)号：WO99057191A1

    公开(公告)日：1999-11-11

    申请号：PCT/US1999/008945

    申请日：1999-04-28

    IPC: C08F2/46 ,  C08F4/38 ,  C08F283/01 ,  C08K5/14 ,  C07C409/00 ,  C08L67/06

    CPC classification number: C08F4/38 ,  C08F283/01 ,  C08F4/28

    Abstract: This invention relates to a method of curing unsaturated polyester resins or mixtures of such resins and a monomer copolymerizable therewith. More particularly, the invention relates to the curing of such resins and mixtures thereof with a composition comprising acetylacetone peroxide (AAP) in an amount of from about 30 to about 35 percent and a high temperature peroxide. Preferably, the high temperature peroxide is t-butyl peroxybenzoate (TBPB) and is present in an amount of from about 5 to about 10 percent of the composition.

    Abstract translation: 本发明涉及一种固化不饱和聚酯树脂或这种树脂的混合物和可与其共聚的单体的方法。 更具体地说，本发明涉及这样的树脂及其混合物与含有约30-约35％量的乙酰丙酮过氧化物（AAP）和高温过氧化物的组合物的固化。 优选地，高温过氧化物是过氧苯甲酸叔丁酯（TBPB），并且其含量为组合物的约5至约10％。

    PROCESS FOR CROSS-LINKING THERMOPLASTIC POLYMERS AND CROSS-LINKING SYSTEM USED THEREIN
    6.
    发明申请
    PROCESS FOR CROSS-LINKING THERMOPLASTIC POLYMERS AND CROSS-LINKING SYSTEM USED THEREIN 审中-公开
    交联热塑性聚合物的方法及其使用的交联体系

    公开(公告)号：WO98050354A1

    公开(公告)日：1998-11-12

    申请号：PCT/US1998/008907

    申请日：1998-05-01

    IPC: C08J3/24 ,  C07C409/00 ,  C08F8/00

    CPC classification number: C08F8/00 ,  C08F110/02

    Abstract: A cross-linking system which includes a 1,2,4-trioxacycloheptane and a crosslink-promoting polyfunctional ethylenically unsaturated compound. This system is employed in a process of cross-linking a thermoplastic polymer. Preferred polymers, useful in this process, include ethylene homopolymers and copolymers.

    Abstract translation: 一种包含1,2,4-三氧杂环庚烷和交联促进多官能烯属不饱和化合物的交联体系。 该系统用于交联热塑性聚合物的方法。 在该方法中有用的优选聚合物包括乙烯均聚物和共聚物。

    PROCESS FOR PRODUCING HYDROGEN PEROXIDE, C1 TO C4 MONOPERCARBOXYLIC ACID AND C4 TO C18 DIPERCARBOXYLIC ACID COMPLEXES BY THE FLUIDISED BED PROCESS
    7.
    发明申请
    PROCESS FOR PRODUCING HYDROGEN PEROXIDE, C1 TO C4 MONOPERCARBOXYLIC ACID AND C4 TO C18 DIPERCARBOXYLIC ACID COMPLEXES BY THE FLUIDISED BED PROCESS 审中-公开
    通过流化床方法生产过氧化氢，C1至C4单羧酸和C4至C18 DIPERCARBOXYLIC酸复合物的方法

    公开(公告)号：WO9517345A3

    公开(公告)日：1995-08-03

    申请号：PCT/EP9404115

    申请日：1994-12-10

    Applicant: BASF AG ,  BREITENBACH JOERG ,  GRABOWSKI SVEN ,  SANNER AXEL

    Inventor： BREITENBACH JOERG ,  GRABOWSKI SVEN ,  SANNER AXEL

    IPC: C07C407/00 ,  C07C409/00 ,  C07C409/24 ,  C07C409/26 ,  C08L5/00 ,  C08L5/16 ,  C08L39/00 ,  C01B15/037 ,  C08K3/20 ,  C08K5/14

    CPC classification number: C07C407/00 ,  C01B15/01 ,  C07C409/24 ,  C07C409/26

    Abstract: The production of hydrogen peroxide, C1 to C4 monopercarboxylic acid and C4 to C18 dipercarboxylic acid complexes by the fluidised bed process by the addition of a solution of hydrogen peroxide, C1 to C4 monopercarboxylic acid, C4 to C18 dipercarboxylic acid or a mixture thereof in water or carboxylic acids to a powdered or pregranulated matrix in or outside the fluidised bed and simultaneously or successively drying of the fluidised bed, in which use is made as a matrix of: A) N-vinyl caprolactam homopolymer, B) N-vinyl caprolactam copolymers with N-vinyl pyrrolidone, N-vinyl imidazole, acryl or methacryl amidopropyl-3-sulphonic acid, acrylic or methacrylic acid or mixtures thereof as comonomers in the proportion by weight of N-vinyl caprolactam to comonomers of 20:1 to 1:20, C) N-vinyl pyrrolidone copolymer with N-vinyl imidazole, acrylic or methacrylic acid or mixtures thereof as comonomers in the proportion by weight of N-vinyl pyrrolidone to comonomers of 20:1 to 1:20, D) N-vinyl imidazole homopolymers which may be substituted in the heterocyclic ring by up to three C1 to C4 alkyl radicals and may be present in C1 to C4 alkyl N-quaternised form, E) mixtures of monosaccharides, oligosaccharides, polysaccharides or derivatives thereof with the polymers A to D in the proportion by weight of 1:99 to 90:10, F) mixtures of monosaccharides, oligosaccharides, starches, starch decomposition products or derivatives thereof with N-vinyl pyrrolidone homopolymers in the proportion by weight of 1:99 to 90:10, G) mixtures of trehalose, saccharose, glucose, α or β or η cyclodextrins or derivatives of said cyclodextrins or mixtures thereof with polymers A to D or with N-vinyl pyrrolidone homopolymers in the proportion by weight of 1:99 to 100:0 or H) in the case of C1 to C4 monopercarboxylic acid and C4 to C18 dipercarboxylic acid complexes, N-vinyl pyrrolidone homopolymers.

    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM
    10.
    发明申请
    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM 审中-公开
    通过形成和利用液相薄膜来氧化烃类的非巴法方法

    公开(公告)号：WO2011053818A2

    公开(公告)日：2011-05-05

    申请号：PCT/US2010/054788

    申请日：2010-10-29

    Applicant: ILLA INTERNATIONAL, LLC ,  ZAKOSHANSKY, Vladimir

    Inventor： ZAKOSHANSKY, Vladimir

    IPC: B01J10/00 ,  C07C407/00 ,  C07C409/00

    CPC classification number: B01J10/02 ,  B01J10/002 ,  B01J2219/0004 ,  C07C407/00 ,  C07C409/02 ,  C07C409/08 ,  C07C409/10 ,  C07C409/12

    Abstract: The purpose of the present invention is to provide an advantageous non-barbotage method for oxidation of aromatic hydrocarbons, that, when implemented in various embodiments thereof, provides significantly higher selectivity, a greater level of safety, Sower capital costs, etc., than conventional oxidation processes utilizing the barbotage technique. The essence of the inventive non-barbotage oxidation process is ensuring that the oxidizing agent delivered to the process reactor undergoes continued contact only with exposed surfaces of the liquid phase of the hydrocarbons being oxidized configured as at least one of: formed liquid phase thin film(s), liquid phase continuous stream(s), and/or liquid phase globule (e.g., droplets, etc.) stream(s), preferably, with the surface area(s) of the exposed surface(s) being maximized to increase contact with an oxidizing agent being directed thereto, to ensure that the inventive oxidation reaction occurs at the border between liquid and gas phases, such that the oxidation reaction effectively occurs by way of contact of the oxidizing agent (e.g., oxygen) from the gas phase with exposed surface(s) of the liquid phase of the hydrocarbons being oxidized. The inventive non-barbotage oxidation process may be implemented in a single reactor, or in plural sequential reactors, and may be implemented both in a stand-alone configuration, and in combination with various conventional barbotage methods for oxidation of aromatic hydrocarbons.

    Abstract translation: 本发明的目的是提供用于芳族烃氧化的有利的非酒渣法，当在其各种实施方案中实施时，其提供比常规的更高选择性，更高水平的安全性，Sower资本成本等。 利用barbotage技术的氧化过程。 本发明的非酒渣氧化方法的实质是确保输送到工艺反应器的氧化剂仅与被氧化的烃的液相的暴露表面持续接触，构成为以下中的至少一种：形成的液相薄膜（ s），液相连续流和/或液相球（例如，液滴等）流，优选地，暴露表面的表面积最大化以增加 与导向其的氧化剂接触，以确保本发明的氧化反应发生在液相和气相之间的边界处，使得氧化反应通过氧化剂（例如氧）与气相接触而有效发生 所述烃的液相的暴露表面被氧化。 本发明的非硼酸盐氧化方法可以在单个反应器中或多个顺序反应器中实施，并且可以以独立构型并结合各种用于芳族烃氧化的常规barbotage方法来实施。

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