CHROMENE-2 DERIVATIVES AND USE THEREOF IN THE TREATMENT OF FIBROSIS
    1.
    发明申请
    CHROMENE-2 DERIVATIVES AND USE THEREOF IN THE TREATMENT OF FIBROSIS 审中-公开
    色素-2衍生物及其在治疗纤维化中的应用

    公开(公告)号:WO2016072946A1

    公开(公告)日:2016-05-12

    申请号:PCT/TR2015/000156

    申请日:2015-04-17

    CPC classification number: C07D311/04 C07C43/202 C07C43/23 C07C49/84 C07C409/02

    Abstract: The present invention is related to chromene-2 derivatives and use thereof in the treatment of fibrosis. The invention is related to the derivatives of a compound having a main structure of 6,7-dimethoxy-chroinenylium perch!orate (1 ) and phamiaceittical compositions, combinations and pharmaceutically suitable salts thereof for the treatment of fibrosis.

    Abstract translation: 本发明涉及色烯-2衍生物及其在治疗纤维化中的用途。 本发明涉及具有主要结构的6,7-二甲氧基 - 胡萝卜素or酸酯(1)的化合物及其药物组合物及其药学上合适的盐用于治疗纤维化的衍生物。

    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM
    3.
    发明申请
    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM 审中-公开
    通过形成和利用液相薄膜来氧化烃类的非巴法方法

    公开(公告)号:WO2011053818A2

    公开(公告)日:2011-05-05

    申请号:PCT/US2010/054788

    申请日:2010-10-29

    Abstract: The purpose of the present invention is to provide an advantageous non-barbotage method for oxidation of aromatic hydrocarbons, that, when implemented in various embodiments thereof, provides significantly higher selectivity, a greater level of safety, Sower capital costs, etc., than conventional oxidation processes utilizing the barbotage technique. The essence of the inventive non-barbotage oxidation process is ensuring that the oxidizing agent delivered to the process reactor undergoes continued contact only with exposed surfaces of the liquid phase of the hydrocarbons being oxidized configured as at least one of: formed liquid phase thin film(s), liquid phase continuous stream(s), and/or liquid phase globule (e.g., droplets, etc.) stream(s), preferably, with the surface area(s) of the exposed surface(s) being maximized to increase contact with an oxidizing agent being directed thereto, to ensure that the inventive oxidation reaction occurs at the border between liquid and gas phases, such that the oxidation reaction effectively occurs by way of contact of the oxidizing agent (e.g., oxygen) from the gas phase with exposed surface(s) of the liquid phase of the hydrocarbons being oxidized. The inventive non-barbotage oxidation process may be implemented in a single reactor, or in plural sequential reactors, and may be implemented both in a stand-alone configuration, and in combination with various conventional barbotage methods for oxidation of aromatic hydrocarbons.

    Abstract translation: 本发明的目的是提供用于芳族烃氧化的有利的非酒渣法,当在其各种实施方案中实施时,其提供比常规的更高选择性,更高水平的安全性,Sower资本成本等。 利用barbotage技术的氧化过程。 本发明的非酒渣氧化方法的实质是确保输送到工艺反应器的氧化剂仅与被氧化的烃的液相的暴露表面持续接触,构成为以下中的至少一种:形成的液相薄膜( s),液相连续流和/或液相球(例如,液滴等)流,优选地,暴露表面的表面积最大化以增加 与导向其的氧化剂接触,以确保本发明的氧化反应发生在液相和气相之间的边界处,使得氧化反应通过氧化剂(例如氧)与气相接触而有效发生 所述烃的液相的暴露表面被氧化。 本发明的非硼酸盐氧化方法可以在单个反应器中或多个顺序反应器中实施,并且可以以独立构型并结合各种用于芳族烃氧化的常规barbotage方法来实施。

    PROCESS FOR CONCENTRATING A MIXTURE CONTAINING ORGANIC HYDROPEROXIDE
    4.
    发明申请
    PROCESS FOR CONCENTRATING A MIXTURE CONTAINING ORGANIC HYDROPEROXIDE 审中-公开
    浓缩含有机氢过氧化物的混合物的方法

    公开(公告)号:WO2014209578A1

    公开(公告)日:2014-12-31

    申请号:PCT/US2014/041410

    申请日:2014-06-06

    Abstract: Method for concentrating an organic hydroperoxide mixture comprising a hydrocarbon and a hydroperoxide corresponding thereto comprises evaporating a first liquid mixture in a thin- film evaporation device followed by separation in a separation zone. Both the evaporation device and the separation zone operate at a low absolute pressure at a temperature lower than the thermal degradation temperature of the hydroperoxide to prevent thermal decomposition thereof. The process is particularly useful for concentrating an oxidation product made from the oxidation of cyclohexylbenzene.

    Abstract translation: 用于浓缩包含对应于其的烃和氢过氧化物的有机氢过氧化物混合物的方法包括在薄膜蒸发装置中蒸发第一液体混合物,然后在分离区中分离。 蒸发装置和分离区都在低于氢过氧化物的热降解温度的温度下在低绝对压力下操作,以防止其热分解。 该方法对于浓缩由环己基苯氧化制得的氧化产物特别有用。

    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM
    5.
    发明申请
    NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM 审中-公开
    通过形成和利用液相薄膜氧化烃的非大气压方法

    公开(公告)号:WO2011053818A3

    公开(公告)日:2011-09-22

    申请号:PCT/US2010054788

    申请日:2010-10-29

    Abstract: The purpose of the present invention is to provide an advantageous non-barbotage method for oxidation of aromatic hydrocarbons, that, when implemented in various embodiments thereof, provides significantly higher selectivity, a greater level of safety, Sower capital costs, etc., than conventional oxidation processes utilizing the barbotage technique. The essence of the inventive non-barbotage oxidation process is ensuring that the oxidizing agent delivered to the process reactor undergoes continued contact only with exposed surfaces of the liquid phase of the hydrocarbons being oxidized configured as at least one of: formed liquid phase thin film(s), liquid phase continuous stream(s), and/or liquid phase globule (e.g., droplets, etc.) stream(s), preferably, with the surface area(s) of the exposed surface(s) being maximized to increase contact with an oxidizing agent being directed thereto, to ensure that the inventive oxidation reaction occurs at the border between liquid and gas phases, such that the oxidation reaction effectively occurs by way of contact of the oxidizing agent (e.g., oxygen) from the gas phase with exposed surface(s) of the liquid phase of the hydrocarbons being oxidized. The inventive non-barbotage oxidation process may be implemented in a single reactor, or in plural sequential reactors, and may be implemented both in a stand-alone configuration, and in combination with various conventional barbotage methods for oxidation of aromatic hydrocarbons.

    Abstract translation: 本发明的目的是提供用于芳族烃氧化的有利的非阻塞方法,当其在各种实施方案中实施时,与常规方法相比,提供了显着更高的选择性,更高的安全性水平,更低的资金成本等 利用barbotage技术的氧化过程。 本发明的非强制氧化工艺的实质是确保输送到工艺反应器的氧化剂仅与被氧化的烃的液相的暴露表面连续接触,所述暴露表面被配置为形成的液相薄膜( s),液相连续流和/或液相小球(例如液滴等)流,优选地使暴露表面的表面积最大化以增加 与导向其的氧化剂接触,以确保本发明的氧化反应发生在液相和气相之间的边界,使得氧化反应通过氧化剂(例如氧气)与气相接触而有效地发生 烃的液相的暴露表面被氧化。 本发明的非破坏氧化过程可以在单个反应器中或在多个连续反应器中实施,并且可以以独立构造实施并且与用于氧化芳香烃的各种常规破碎方法结合实施。

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