公开(公告)号：WO2015121378A1

公开(公告)日：2015-08-20

申请号：PCT/EP2015/053020

申请日：2015-02-12

Applicant: AKER BIOMARINE ANTARCTIC AS

Inventor： HUPFELD, Stefan ,  EVJEN, Tove Julie ,  MYHREN, Finn ,  THØGERSEN, Håvard

IPC: A61K35/612 ,  A23L1/325 ,  A61K31/685

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/12 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4875 ,  A61K31/683 ,  A61K35/612

Abstract: Current krill oil extracts are liquid at room temperature and include only about 45-55% phospholipids. As the purity of phospholipids increases, the extracts become more viscous, making them difficult to handle and process. The invention mixes these pure materials with viscosity-reducing agents to make them amenable to processes such as encapsulation. Thus the invention retains the useful liquid characteristics of known krill extracts while providing much higher concentrations of phospholipids.

Abstract translation: 目前的磷虾油在室温下是液体，仅含约45-55％的磷脂。 随着磷脂的纯度增加，提取物变得更粘稠，使其难以处理和加工。 本发明将这些纯材料与减粘剂混合，使其适用于诸如包封的方法。 因此，本发明保留已知的磷虾提取物的有用的液体特性，同时提供高得多的磷脂浓度。

公开(公告)号：WO2015114368A1

公开(公告)日：2015-08-06

申请号：PCT/GB2015/050245

申请日：2015-01-30

Applicant: ATLAS GENETICS LIMITED

Inventor： PEARCE, David ,  STYLES, David

IPC: C12Q1/68

CPC classification number: C12Q1/6893

Abstract: A method of detecting the presence of Trichomonas vaginalis in a sample. The method involves detecting a target sequence taken from the TVAG_003780 gene in a sequence-specific manner. The method may involve a step of amplifying the target sequence, and may involve hybridising the target sequence to a nucleic acid probe and identifying hybridisation.

Abstract translation: 检测样品中阴道毛滴虫存在的方法。 该方法涉及以序列特异性方式检测从TVAG_003780基因取得的靶序列。 该方法可以包括扩增靶序列的步骤，并且可以包括将靶序列与核酸探针杂交并鉴定杂交。

公开(公告)号：WO2015015181A1

公开(公告)日：2015-02-05

申请号：PCT/GB2014/052310

申请日：2014-07-28

Applicant: ATLAS GENETICS LIMITED

Inventor： TAYLOR, Jay Kendall ,  MULLARKEY, Toby Charles Edward ,  ARLETT, Ben

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502738 ,  B01L2400/0638 ,  F16K99/0015 ,  F16K2099/0071 ,  F16K2099/0084

Abstract: A valve for a fluidic cartridge comprises a valve chamber having first and second openings connected to first and second passageways, respectively;a flexible membrane movable between an open position, in which the flexible membrane is spaced apart from the first and second openings to permit fluid to flow between the passageways and a closed position, in which the flexible membrane seals against at least one of the first and second openings to prevent fluid flow between the passageways; and an actuator configured to act on the flexible membrane to move it from its open position to its closed position, the actuator comprising a latching mechanism configured to latch the actuator such that it maintains the flexible membrane in its closed position.

Abstract translation: 用于流体盒的阀包括分别具有连接到第一和第二通道的第一和第二开口的阀室;可在打开位置之间移动的柔性膜，柔性膜与第一和第二开口间隔开，以允许流体 在所述通道和关闭位置之间流动，其中所述柔性膜密封所述第一和第二开口中的至少一个，以防止流体在所述通道之间流动; 以及致动器，其构造成作用在所述柔性膜上以将其从其打开位置移动到其关闭位置，所述致动器包括闩锁机构，所述闩锁机构构造成闩锁所述致动器，使得其将所述柔性膜保持在其关闭位置。

公开(公告)号：WO2013186753A1

公开(公告)日：2013-12-19

申请号：PCT/IB2013/054886

申请日：2013-06-14

Applicant: NOVARTIS AG ,  INSTITUT PASTEUR

Inventor： PIZZA, Mariagrazia ,  DULL, Peter ,  GIULIANI, Marzia Monica ,  TAHA, Muhamed-Kheir ,  HONG, Eva ,  DEGHMANE, Ala-Eddine

IPC: A61K39/095

CPC classification number: A61K39/095 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/70

Abstract: A method for immunising a subject against serogroup X meningococcus by administering a vaccine comprising one, two or all three of: (i) a meningococcal fHbp antigen; (ii) a meningococcal NHBA antigen; and/or (iii) a meningococcal NadA antigen.The vaccine may also include meningococcal outer membrane vesicles.

Abstract translation: 一种通过施用包含以下的一种，两种或全部三种的疫苗来免疫受试者抵抗血清群X脑膜炎球菌的方法：（i）脑膜炎球菌fHbp抗原; （ii）脑膜炎球菌NHBA抗原; 和/或（iii）脑膜炎球菌NadA抗原。疫苗还可以包括脑膜炎球菌外膜囊泡。

公开(公告)号：WO2013030589A2

公开(公告)日：2013-03-07

申请号：PCT/GB2012/052141

申请日：2012-08-31

Applicant: NOVARTIS AG ,  CHAN, Gerald ,  AKHTER, Asad

Inventor： CHAN, Gerald ,  AKHTER, Asad

IPC: B65B67/00 ,  A61J1/10 ,  A61J1/16

CPC classification number: A61J1/16 ,  A61J1/10 ,  A61J2200/76 ,  B65B67/00

Abstract: A device for filling a sample bag, comprising first and second walls connected so as to define a defined space, the device being designed to receive a sample bag such that the sample bag can be filled to a measured volume. The device is useful for accurately depositing a measured volume in a flexible sample bag when taking in-process and product fluid samples during manufacture, testing, and quantifying of pharmaceutical compositions.

Abstract translation: 一种用于填充样品袋的装置，包括连接以限定限定空间的第一和第二壁，所述装置被设计成接收样品袋，使得样品袋可以填充到测量体积。 该装置可用于在制造，测试和定量药物组合物期间在采集过程中和产品流体样品时精确地沉积在柔性样品袋中的测量体积。

公开(公告)号：WO2013030378A1

公开(公告)日：2013-03-07

申请号：PCT/EP2012/067032

申请日：2012-08-31

Applicant: NOVARTIS AG ,  BAGNOLI, Fabio ,  BAUDNER, Barbara ,  BUFALI, Simone

Inventor： BAGNOLI, Fabio ,  BAUDNER, Barbara ,  BUFALI, Simone

IPC: A61K39/085 ,  A61P31/04

CPC classification number: A61K39/085 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55572

Abstract: The efficacy of S.aureus vaccines can be enhanced by adjuvanting S.aureus antigens with a mixture of a TLR agonist (preferably a TLR7 agonist) and an insoluble metal salt (preferably an aluminium salt). The TLR agonist is typically adsorbed to the metal salt. A S.aureus antigen can also be adsorbed to the metal salt.

Abstract translation: 通过用TLR激动剂（优选TLR7激动剂）和不溶性金属盐（优选铝盐）的混合物佐剂金黄色葡萄球菌抗原来增强金黄色葡萄球菌疫苗的功效。 TLR激动剂通常被吸附到金属盐上。 金黄色葡萄球菌抗原也可以被吸附到金属盐上。

公开(公告)号：WO2012153302A1

公开(公告)日：2012-11-15

申请号：PCT/IB2012/052354

申请日：2012-05-11

Applicant: NOVARTIS AG ,  KIMURA, Alan ,  DULL, Peter

Inventor： KIMURA, Alan ,  DULL, Peter

IPC: A61K35/74 ,  A61K38/16 ,  A61P43/00 ,  A61K31/167

CPC classification number: A61K39/095 ,  A61K35/74 ,  A61K38/164 ,  A61K45/06

Abstract: A method for immunising a human subject, wherein the subject receives (i) an immunogenic composition comprising bacterial vesicles and (ii) an antipyretic, and wherein the immunogenic composition and the antipyretic are administered to the subject within 24 hours of each other. Paracetamol significantly reducesfever rates without negatively affecting the immunogenicity either of a meningococcal vesicle vaccine or of concomitantly-administered antigens.

Abstract translation: 一种用于免疫人受试者的方法，其中所述受试者接受（i）包含细菌囊泡的免疫原性组合物和（ii）解热药，并且其中所述免疫原性组合物和解热药在彼此的24小时内施用于受试者。 对乙酰氨基酚显着降低发病率，而不会对脑膜炎球菌囊泡疫苗或伴随施用的抗原的免疫原性产生负面影响。

公开(公告)号：WO2012117382A1

公开(公告)日：2012-09-07

申请号：PCT/IB2012/051007

申请日：2012-03-02

Applicant: NOVARTIS AG ,  UNIVERSITAET REGENSBURG ,  BROEKER, Michael ,  MODROW, Susanne ,  BREDEL, Simon

Inventor： BROEKER, Michael ,  MODROW, Susanne ,  BREDEL, Simon

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/015 ,  G01N2469/10

Abstract: An improved method for the detection of parvovirus B19 in a sample is provided, the improvement consisting of detecting a parvovirus B19 non-structural protein in said sample.

Abstract translation: 提供了用于检测样品中细小病毒B19的改进方法，该改进包括检测所述样品中的细小病毒B19非结构蛋白。

公开(公告)号：WO2012085668A3

公开(公告)日：2012-06-28

申请号：PCT/IB2011/003244

申请日：2011-12-23

Applicant: NOVARTIS AG ,  COSTANTINO, Paolo ,  ADAMO, Roberto ,  ROMANO, Maria Rosaria ,  DANIEL, Elisa ,  BERTI, Francesco ,  CAPPELLITTI, Emilia ,  LAY, Luigi

Inventor： COSTANTINO, Paolo ,  ADAMO, Roberto ,  ROMANO, Maria Rosaria ,  DANIEL, Elisa ,  BERTI, Francesco ,  CAPPELLITTI, Emilia ,  LAY, Luigi

IPC: C07H15/04 ,  C07H15/18 ,  A61K39/08 ,  C08B37/00 ,  C08L5/00 ,  C12P19/04 ,  A61P1/12 ,  A61P31/04 ,  A61K39/40 ,  A61K39/44 ,  A61K47/48

Abstract: The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.

公开(公告)号：WO2012049662A1

公开(公告)日：2012-04-19

申请号：PCT/IB2011/054569

申请日：2011-10-14

Applicant: NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH SRL ,  MARTIN, Laura ,  SAUL, Allan ,  GERKE, Christiane ,  SA SILVA, Sara

Inventor： MARTIN, Laura ,  SAUL, Allan ,  GERKE, Christiane ,  SA SILVA, Sara

IPC: C12N1/20 ,  C07K14/255

CPC classification number: C07K14/255 ,  A61K39/0275 ,  A61K2039/522 ,  A61K2039/543 ,  C12P1/04 ,  Y02A50/482 ,  Y02A50/484

Abstract: Hyperblebbing Salmonella strains are generated by disrupting one or more components of the Tol-Pal system, such as TolR. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.

Abstract translation: 超嗜性沙门菌属菌株是通过破坏Tol-Pal系统的一种或多种组分，如TolR产生的。 这些菌株的泡沫是免疫接种的有用免疫原。 这些泡中发现的各种蛋白质也可以用作免疫原。