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    PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III
    97.
    发明申请
    PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III 审中-公开
    磺基苯甲酸酯多羟基化合物的方法

    公开(公告)号：WO2013175506A3

    公开(公告)日：2014-06-26

    申请号：PCT/IN2013000325

    申请日：2013-05-21

    Applicant: HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SRINIVASA RAO THUNGATHURTHY ,  VAMSI KRISHNA BANDI

    Inventor： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SRINIVASA RAO THUNGATHURTHY ,  VAMSI KRISHNA BANDI

    IPC: C07D213/78

    CPC classification number: C07D213/81

    Abstract: The present invention provides a novel process for the preparation of sorafenib tosylate polymorph III. The preferred embodiment for the preparation of sorafenib tosylate polymorph III, comprises: providing a solution comprising sorafenib, p-toluenesulfonic acid and a solvent selected from a group consisting of a mixture of dimethyl acetamide and an alcoholic solvent, a mixture of dimethylformamide and an alcoholic solvent and a mixture thereof; adding an alcoholic solvent to the solution obtained; isolating the solid; slurring the solid with an alcoholic solvent; and isolating sorafenib tosylate polymorph III.

    Abstract translation: 本发明提供了制备索拉非尼甲苯磺酸盐多晶型III的新方法。 用于制备索拉非尼甲苯磺酸盐多晶型III的优选实施方案包括：提供包含索拉菲尼，对甲苯磺酸和选自二甲基乙酰胺和醇溶剂的混合物的溶剂，二甲基甲酰胺和醇的混合物 溶剂及其混合物; 向所得溶液中加入醇溶剂; 分离固体; 用醇溶剂捣固固体; 并分离索拉非尼甲苯磺酸盐多晶型III。

    IBANDRONATE SODIUM SOLID DISPERSION
    99.
    发明申请
    IBANDRONATE SODIUM SOLID DISPERSION 审中-公开

    公开(公告)号：WO2013179305A1

    公开(公告)日：2013-12-05

    申请号：PCT/IN2013/000327

    申请日：2013-05-21

    Applicant: HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  SUBASH CHANDER REDDY, Kesireddy ,  VAMSI KRISHNA, Bandi

    Inventor： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  SUBASH CHANDER REDDY, Kesireddy ,  VAMSI KRISHNA, Bandi

    IPC: A61K31/663

    CPC classification number: A61K31/663 ,  A61K9/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

    Abstract: The present invention provides a novel substantially amorphous solid dispersion of ibandronate sodium in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it. In a preferred embodiment the process for the preparation of amorphous solid dispersion of ibandronate sodium in combination with a pharmaceutically acceptable carrier comprises: preparing a solution comprising a mixture of ibandronate sodium and one or more pharmaceutically acceptable carriers selected from copovidone, ethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, span 20 or soluplus in a solvent, water or mixture thereof; and removing the solvent or water to obtain substantially amorphous solid dispersion of ibandronate sodium in combination with a pharmaceutically acceptable carrier.

    Abstract translation: 本发明提供了一种新颖的伊班膦酸钠与药学上可接受的载体组合的基本上无定形的固体分散体，其制备方法和包含它的药物组合物。 在优选的实施方案中，将伊班膦酸钠与药学上可接受的载体组合的无定形固体分散体的制备方法包括：制备包含伊班膦酸钠和一种或多种药学上可接受的载体的混合物的溶液，所述载体选自共聚维酮，乙基纤维素，羟丙基甲基纤维素 ，聚乙二醇，跨度20或溶剂在溶剂中，水或其混合物; 并除去溶剂或水以获得伊班膦酸钠与药学上可接受的载体的基本上无定形的固体分散体。

    IVABRADINE HYDROCHLORIDE SOLID DISPERSION
    100.
    发明申请
    IVABRADINE HYDROCHLORIDE SOLID DISPERSION 审中-公开
    IVABRADINE HYDROCHLORIDE固体分散体

    公开(公告)号：WO2013150544A3

    公开(公告)日：2013-12-05

    申请号：PCT/IN2013000212

    申请日：2013-04-01

    Applicant: HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SRINIVASA RAO THUNGATHURTHY ,  VAMSI KRISHNA BANDI

    Inventor： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SRINIVASA RAO THUNGATHURTHY ,  VAMSI KRISHNA BANDI

    IPC: C07D223/18

    CPC classification number: A61K31/55 ,  A61K9/146 ,  A61K9/1694 ,  C07D223/16

    Abstract: The present invention provides a compound of 7,8-dimethoxy-3-[3-[[(1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl]methylamino]propyl]-1,3-de-hydro-7,8-dimethoxy-2H-3-benzazepin-2-one oxalate (de-hydro ivabradine oxalate salt) and process for its preparation. The present invention also provides a process for the purification of de-hydro ivabradine oxalate salt. The present invention further provides a novel process for the preparation of ivabradine using novel intermediate. The present invention further provides a novel amorphous solid dispersion of ivabradine hydrochloride in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

    Abstract translation: 本发明提供7,8-二甲氧基-3- [3 - [[（1S） - （4,5-二甲氧基苯并环丁烷-1-基）甲基]甲基氨基]丙基] -1,3-脱水 - 7,8-二甲氧基-2H-3-苯并氮杂-2-酮草酸盐（去氢伊伐布拉定草酸盐）及其制备方法。 本发明还提供了一种用于纯化去氢伊伐布拉定草酸盐的方法。 本发明还提供了使用新型中间体制备伊伐布雷丁的新方法。 本发明还提供了与药学上可接受的载体组合的盐酸伊伐布雷德的新型无定形固体分散体，其制备方法和包含其的药物组合物。

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