利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

242 records (took 0.023 seconds)

    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES
    91.
    发明申请
    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 审中-公开

    公开(公告)号：WO2020112816A1

    公开(公告)日：2020-06-04

    申请号：PCT/US2019/063311

    申请日：2019-11-26

    Applicant: SURMODICS, INC.

    Inventor： CHAPPA, Ralph A. ,  MILITELLO, Michael

    IPC: A61M25/10 ,  B05B13/04

    Abstract: Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.

    DELIVERY OF HYDROPHOBIC ACTIVE AGENTS FROM HYDROPHILIC POLYETHER BLOCK AMIDE COPOLYMER SURFACES
    92.
    发明申请
    DELIVERY OF HYDROPHOBIC ACTIVE AGENTS FROM HYDROPHILIC POLYETHER BLOCK AMIDE COPOLYMER SURFACES 审中-公开

    公开(公告)号：WO2018118671A1

    公开(公告)日：2018-06-28

    申请号：PCT/US2017/066573

    申请日：2017-12-15

    Applicant: SURMODICS, INC.

    Inventor： KLOKE, Timothy M.

    IPC: A61L29/08 ,  A61L29/16

    Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.

    LUBRICIOUS INSERTION TOOLS FOR MEDICAL DEVICES AND METHODS FOR USING
    93.
    发明申请
    LUBRICIOUS INSERTION TOOLS FOR MEDICAL DEVICES AND METHODS FOR USING 审中-公开
    用于医疗设备的润滑插入工具和使用方法

    公开(公告)号：WO2018053124A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/051555

    申请日：2017-09-14

    Applicant: SURMODICS, INC.

    Inventor： TROCKE, Amy ,  SUTTON, Gregg S. ,  SLAGER, Joram

    IPC: A61M25/06 ,  A61M25/10

    Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.

    Abstract translation: 本公开提供了便于诸如气囊导管之类的医疗装置进入体内并且可以在气囊插入，安全性和药物输送方面提供优点的插入工具和物品。 插入工具包括容纳球囊导管的球囊部分的管状部分，以及管状部分的壁或管状壁中的一个或多个裂缝中的一个或多个分离边缘。 插入工具还包括近侧翼片，该近侧翼片从具有相对于纵向轴线倾斜一角度的部分的第二纵向半部延伸，或者呈固体物品的形式，该固体物品包括固定到 管状部分的第二纵向一半; 或分别从管状部分的第一纵向半部和第二纵向半部延伸的第一凸耳和第二凸耳。

    LUBRICIOUS COATINGS WITH SURFACE SALT GROUPS
    94.
    发明申请
    LUBRICIOUS COATINGS WITH SURFACE SALT GROUPS 审中-公开

    公开(公告)号：WO2017116707A3

    公开(公告)日：2017-07-06

    申请号：PCT/US2016/066559

    申请日：2016-12-14

    Applicant: SURMODICS, INC.

    Inventor： BABCOCK, David E. ,  SLAGER, Joram ,  HERGENROTHER, Robert W.

    IPC: A61L29/08 ,  A61L29/14 ,  B05D1/18 ,  B05D3/00

    Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

    INSERTABLE MEDICAL DEVICE SYSTEM WITH PLAQUE TREATMENT PORTION AND METHODS OF USING
    95.
    发明申请
    INSERTABLE MEDICAL DEVICE SYSTEM WITH PLAQUE TREATMENT PORTION AND METHODS OF USING 审中-公开
    具有PLAQUE处理部分的绝缘医疗装置系统及其使用方法

    公开(公告)号：WO2016138260A1

    公开(公告)日：2016-09-01

    申请号：PCT/US2016/019559

    申请日：2016-02-25

    Applicant: SURMODICS, INC.

    Inventor： OLSON, Charlie

    IPC: A61M25/10 ,  A61B17/3207 ,  A61B17/22

    CPC classification number: A61B17/22 ,  A61B17/320725 ,  A61B2017/00685 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2017/22084 ,  A61B2017/320004 ,  A61B2017/320008 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/109

    Abstract: The disclosure provides plaque treatment catheter assemblies for the treatment of arterial plaques and removal of clots. One assembly includes a second catheter tube movable within a first catheter tube, and an expansion member movable within the second tube. The second catheter tube has one or more distally-disposed and outwardly-expandable plaque treatment portion(s). Another assembly includes a catheter tube and at least one channel(s) within the catheter. The channel includes an elongate member with a distally-disposed plaque scoring or clot retrieval member. Optionally, the assembly includes an expandable member that can cause movement of the scoring member.

    Abstract translation: 本公开提供用于治疗动脉斑块和去除凝块的斑块治疗导管组件。 一个组件包括可在第一导管内移动的第二导管，以及可在第二管内移动的扩张构件。 第二导管具有一个或多个远端布置且向外扩张的斑块处理部分。 另一组件包括导管和导管内的至少一个通道。 通道包括具有远端布置的斑块刻痕或凝块取回构件的细长构件。 可选地，组件包括可引起刻痕构件移动的可扩张构件。

    INSERTION TOOLS FOR MEDICAL DEVICE
    96.
    发明申请
    INSERTION TOOLS FOR MEDICAL DEVICE 审中-公开
    医疗器械插入工具

    公开(公告)号：WO2016115361A1

    公开(公告)日：2016-07-21

    申请号：PCT/US2016/013430

    申请日：2016-01-14

    Applicant: SURMODICS, INC.

    Inventor： JELLE, Bruce ,  SLAGER, Joram ,  MCGONIGLE, Joseph S. ,  MURPHY, Rick ,  BACH, Andrew G. ,  WOODWICK SIDES, Teryl L, ,  ANGAMUTHU, Ambereen ,  LUNDQUIST, Sean ,  OPPERMAN, Gary ,  LOCKWOOD, Nathan A.

    IPC: A61M25/10

    CPC classification number: A61F2/2433 ,  A61M25/0102 ,  A61M25/0668 ,  A61M25/09041 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/1081

    Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.

    Abstract translation: 本公开提供了便于将诸如气囊导管的医疗装置进入体内的插入工具和物品。 在实施例中，插入工具具有细长的中空本体（50），其能够在插入过程期间保护医疗装置的一部分，例如球囊导管的球囊。 在一个实施例中，插入工具具有细长的中空本体（131），锥形远端（135）和在近端处的可固定球囊导管的一部分的锁定机构（133）。 在远端处的开口可以允许球囊在折叠的未膨胀状态下通过。

    LUBRICIOUS MEDICAL DEVICE ELEMENTS
    97.
    发明申请
    LUBRICIOUS MEDICAL DEVICE ELEMENTS 审中-公开
    润滑医疗设备元件

    公开(公告)号：WO2016053831A1

    公开(公告)日：2016-04-07

    申请号：PCT/US2015/052565

    申请日：2015-09-28

    Applicant: SURMODICS, INC.

    Inventor： CHAPPA, Ralph A. ,  LOCKWOOD, Nathan A. ,  MCGONIGLE, Joseph Schmidt

    IPC: A61L29/04 ,  A61L29/08 ,  A61L29/14 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

    CPC classification number: A61L29/14 ,  A61L29/049 ,  A61L29/085 ,  A61L31/041 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/06 ,  C08J3/203 ,  C08J2375/04 ,  C08J2429/10 ,  C08J2437/00 ,  C08L73/02 ,  C08L75/04

    Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties.In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例包括由具有光滑性质的聚合物形成的医疗装置元件。在一个实施例中，包括形成医疗装置元件的方法。 该方法可以包括混合第一聚合物组分和第二聚合物组分以形成聚合物混合物。 该方法还可以包括将聚合物混合物形成到医疗装置元件中。 该方法还可以包括用酸或碱中的至少一种处理聚合物混合物。 在一个实施例中，包括医疗装置。 医疗装置可以包括润滑元件，润滑元件包括第一聚合物组分和第二聚合物组分的混合物。 第二聚合物组分可以包括在形成元素之后用至少一种酸或碱处理的聚合物。 本文还包括其它实施例。

    SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES
    99.
    发明申请
    SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES 审中-公开
    用于制备晶体结构的颗粒，组合物和含有颗粒物的制品的溶剂方法

    公开(公告)号：WO2014201236A1

    公开(公告)日：2014-12-18

    申请号：PCT/US2014/042101

    申请日：2014-06-12

    Applicant: SURMODICS, INC.

    Inventor： SLAGER, Joram ,  KURDYUMOV, Aleksey V. ,  HEYER, Toni M.

    IPC: A61K9/14 ,  A61K31/436 ,  A61L31/16 ,  A61L29/16 ,  A61M25/10

    CPC classification number: A61L29/16 ,  A61K9/0019 ,  A61K9/14 ,  A61K31/436 ,  A61L2300/416 ,  C07D498/18 ,  Y10T428/2982

    Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20 µm or less, or 10 µm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject.

    Abstract translation: 本发明提供治疗性微粒，其包括固体状结晶形式的大环内酯如雷帕霉素，其尺寸为20μm或更小或10μm或更小。 通过制备具有大环内酯和第一（例如二甲苯）和第二（例如醇，丙酮或乙腈）溶剂的组合物来形成颗粒。 在组合物中，大环内酯的最大溶解度大于单独溶解在第一或第二溶剂中的大环内酯的最大溶解度。 然后将第一和第二溶剂从组合物中蒸发以提供大环内酯颗粒。 在另一种方法中，颗粒可以通过包括超声处理和搅拌/蒸发步骤的方法形成，并且颗粒可以从在过程中形成的过饱和溶液获得。 颗粒显示出期望的低多分散性，并且可以用于治疗组合物，或者可以与用于治疗受试者的可植入或可插入的医疗装置相关联。

Patent Agency Ranking