公开(公告)号：WO2014110407A3

公开(公告)日：2014-07-17

申请号：PCT/US2014/011096

申请日：2014-01-10

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  KURDYUMOV, Aleksey V. ,  MCGONIGLE, Joseph Schmidt ,  HERGENROTHER, Robert W. ,  LOCKWOOD, Nathan A. ,  VENTURA, Joseph ,  STUCKE, Sean M.

IPC: A61B5/04 ,  A61N1/04 ,  A61N1/05 ,  C08G61/12 ,  C07D495/04 ,  C07D519/00 ,  C09D5/24 ,  C08G61/02 ,  C08G73/02 ,  H01B1/12

Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers and polymers are described and electrically conductive coatings that include activatable conductive polymers.

Abstract translation: 本文公开了可活化的导电组合物和制备和使用可活化的导电组合物的方法。 具体而言，描述了可活化的导电单体和聚合物以及包含可活化导电聚合物的导电涂层。

公开(公告)号：WO2017116707A2

公开(公告)日：2017-07-06

申请号：PCT/US2016/066559

申请日：2016-12-14

Applicant: SURMODICS, INC.

Inventor： BABCOCK, David E. ,  SLAGER, Joram ,  HERGENROTHER, Robert W.

CPC classification number: A61L29/085 ,  A61L29/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/007 ,  B05D3/067 ,  B05D5/08 ,  B05D7/02 ,  B05D7/54 ,  C08L5/08 ,  C08L29/04 ,  C08L33/08

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

Abstract translation: 这里的实施方案包括涂布的医疗装置和具有盐基团的涂层。 在一个实施例中，包括涂覆的医疗装置，涂覆的医疗装置包括基底和设置在基底上的聚合物层。 聚合物层包含聚合物并具有外表面。 涂覆的医疗装置还包括与聚合物层的聚合物结合并设置在聚合物层的外表面上的多个盐基团。 盐基团可以是反应性基团与酸或碱的反应产物。 在一个实施例中，包括制造医疗装置的方法。 其他实施例也包括在本文中。

公开(公告)号：WO2017116707A3

公开(公告)日：2017-07-06

申请号：PCT/US2016/066559

申请日：2016-12-14

Applicant: SURMODICS, INC.

Inventor： BABCOCK, David E. ,  SLAGER, Joram ,  HERGENROTHER, Robert W.

IPC: A61L29/08 ,  A61L29/14 ,  B05D1/18 ,  B05D3/00

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

公开(公告)号：WO2015031265A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/052542

申请日：2014-08-25

Applicant: SURMODICS, INC. ,  HENDRICKS, Jeffrey L. ,  RICHARDSON-BURNS, Sarah M. ,  MALLIRES, Kyle ,  SPANNINGA, Sarah A.

Inventor： HENDRICKS, Jeffrey L. ,  RICHARDSON-BURNS, Sarah M. ,  MALLIRES, Kyle ,  SPANNINGA, Sarah A. ,  LOCKWOOD, Nathan A. ,  HERGENROTHER, Robert W. ,  JELLE, Bruce M.

IPC: C09D5/44 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06

CPC classification number: C09D5/24 ,  A61B5/6846 ,  A61B18/12 ,  A61B2018/00071 ,  A61B2018/00136 ,  A61N1/05 ,  C09D5/4476

Abstract: The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.

Abstract translation: 本发明包括导电聚合物涂层，医疗装置，涂层溶液及其制备方法。 用于形成导电聚合物层的涂布溶液可以包括导电单体，至少一种包含阴离子光反应性交联剂或阴离子光反应性亲水性聚合物的光反应性组分和溶剂。 医疗装置可以包括设置在电极上的电极和导电涂层。 导电涂层可以包括导电单体和至少一种光反应组分的反应产物。 本文还包括其他方面。

公开(公告)号：WO2014071387A1

公开(公告)日：2014-05-08

申请号：PCT/US2013/068539

申请日：2013-11-05

Applicant: SURMODICS, INC.

Inventor： VENTURA, Joseph ,  WADMAN, Shannon ,  SLAGER, Joram ,  MCGONIGLE, Joseph Schmidt ,  HERGENROTHER, Robert W.

IPC: A61K47/34 ,  A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  A61K31/337

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

公开(公告)号：WO2011072199A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/059832

申请日：2010-12-10

Applicant: SURMODICS, INC. ,  SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

Inventor： SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

IPC: G03F7/031

CPC classification number: G03F7/031 ,  C07C309/42 ,  C07C333/08 ,  C08F2/50 ,  G03F7/165

Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.

Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。

公开(公告)号：WO2007025059A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/033109

申请日：2006-08-24

Applicant: SURMODICS, INC. ,  HERGENROTHER, Robert W. ,  JELLE, Bruce M.

Inventor： HERGENROTHER, Robert W. ,  JELLE, Bruce M.

IPC: C23C26/00 ,  A61L31/10 ,  C08L65/04

CPC classification number: C23C26/00 ,  A61L27/18 ,  B05D1/38 ,  B05D1/60 ,  B05D3/067 ,  B05D3/107 ,  B05D7/54 ,  C09D165/04 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31931 ,  Y10T428/31935 ,  C08L83/04

Abstract: The invention relates to coating systems having one or more hydrophobic layers bonded to a substrate with a silane composition and methods of making and using the same. In an embodiment, the invention includes an article having a substrate, a base coating layer covalently bonded to the surface of the substrate and a hydrophobic polymer layer disposed on the base coating layer. In an embodiment, the invention includes a method for forming an article including applying a base layer coating solution onto a substrate to form a base layer, applying a hydrophobic polymer layer onto the base layer, and applying actinic energy to the substrate.

Abstract translation: 本发明涉及具有一个或多个用硅烷组合物结合到基底上的疏水层的涂料体系及其制备和使用方法。 在一个实施方案中，本发明包括具有基底，共价结合到基底表面的基底涂层和设置在基底涂层上的疏水性聚合物层的制品。 在一个实施方案中，本发明包括一种用于形成制品的方法，包括将基底涂层溶液施加到基底上以形成基底层，在基底层上施加疏水性聚合物层，以及向基底施加光化能。