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    CELL PERMEABLE INHIBITORS OF THE SCAFFOLD PROTEIN PLENTY OF SH3 DOMAINS (POSH) OR SH3RFL
    91.
    发明申请
    CELL PERMEABLE INHIBITORS OF THE SCAFFOLD PROTEIN PLENTY OF SH3 DOMAINS (POSH) OR SH3RFL 审中-公开
    SH3域（POSH）或SH3RFL的SCAFF蛋白质细胞的细胞渗透性抑制剂

    公开(公告)号：WO2015023824A2

    公开(公告)日：2015-02-19

    申请号：PCT/US2014051019

    申请日：2014-08-14

    Applicant: UNIV MISSOURI

    Inventor： DANIELS MARK

    IPC: A61K38/17

    CPC classification number: A61K38/1709 ,  A61K38/00 ,  A61K47/48246 ,  A61K47/64 ,  C07K7/08 ,  C07K14/005 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/10 ,  C12N7/00 ,  C12N2740/16322 ,  C12N2740/16371

    Abstract: Here, we identify Plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multi-protein scaffold network for TCR-mediated JNK1 activation in CD8+ T-cells. Disruption of the POSH/JIP-1 complex led to profound defects in the activation of JNK1, as well as deficient activation or induction of the transcription factors c-Jun, T-bet and Eomesodermin. Furthermore, disruption of the POSH/JIP complex in CD8+ T-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors. Collectively, these data identify a mechanism for the specific regulation of TCR-dependent JNK1 activation and function that is key for CD8+ T-cell responses. The present invention describes a group of compounds that individually or in concert target a common set of biological pathways important in T cell function, activation of innate inflammation, ischemic reperfusion injury, HIV release and oncogenesis.

    Abstract translation: 在这里，我们确定了大量SH3（POSH）和JNK相互作用蛋白1（JIP-1）作为CD8 + T细胞中TCR介导的JNK1激活的多蛋白支架网络。 POSH / JIP-1复合物的破坏导致JNK1激活的深刻缺陷，以及转录因子c-Jun，T-bet和Eomesodermin的活化或诱导不足。 此外，CD8 + T细胞中POSH / JIP复合物的破坏导致增殖受损，细胞因子表达降低，以及不能控制肿瘤。 总的来说，这些数据确定了TCR依赖性JNK1激活和功能的特异性调节机制，这是CD8 + T细胞应答的关键。 本发明描述了一组化合物，其单独地或一致地靶向在T细胞功能，先天性炎症的激活，缺血再灌注损伤，HIV释放和肿瘤发生中重要的常见生物学途径。

    ANTI-VEGF ANTIBODY/FRAGMENT CONJUGATED GOLD NANOPARTICLES, AND FABRICATION AND THERAPEUTIC METHODS
    96.
    发明申请
    ANTI-VEGF ANTIBODY/FRAGMENT CONJUGATED GOLD NANOPARTICLES, AND FABRICATION AND THERAPEUTIC METHODS 审中-公开
    抗VEGF抗体/片段共轭金纳米颗粒，以及制备和治疗方法

    公开(公告)号：WO2012054564A3

    公开(公告)日：2012-07-05

    申请号：PCT/US2011056825

    申请日：2011-10-19

    Applicant: UNIV MISSOURI ,  SHUKLA RAVI ,  HAINSWORTH DEAN P ,  KATTI KATTESH V ,  KANNAN RAGHURAMAN

    Inventor： SHUKLA RAVI ,  HAINSWORTH DEAN P ,  KATTI KATTESH V ,  KANNAN RAGHURAMAN

    IPC: A61K47/48 ,  A61K9/16 ,  A61K39/395 ,  A61K47/02 ,  A61P35/00

    CPC classification number: A61K9/0051 ,  A61K47/6845 ,  A61K47/6923 ,  A61K47/6929 ,  C07K16/22

    Abstract: Preferred embodiments of the invention include gold nanoparticles, preferably less than about 20nm, that are conjugated with biologically active anti- VEGF antibody or a fragment derived therefrom. The particles can be formed by a "one-pot" synthesis method of the invention, in which the biologically active anti-VEGF antibody or a fragment derived therefrom acts to stabilize formed gold nanoparticles while simultaneously retaining biological activity. The method uses a reducing agent of nontoxic trimeric alanine compound that is benign toward the biological activity of the anti-VEGF antibody or a fragment derived therefrom. Therapeutic methods of the invention include injection of a solution of conjugated gold nanoparticles of the invention at vascularisation sites such as cancer sites and intraocular injection.

    Abstract translation: 本发明的优选实施方案包括与生物活性抗VEGF抗体或衍生自其的片段缀合的金纳米颗粒，优选小于约20nm。 颗粒可以通过本发明的“一锅”合成方法形成，其中生物活性抗VEGF抗体或其衍生的片段起着稳定形成的金纳米颗粒的作用，同时保留生物活性。 该方法使用对抗VEGF抗体的生物活性良好的无毒三聚体丙氨酸化合物或其衍生的片段的还原剂。 本发明的治疗方法包括将本发明的共轭金纳米颗粒的溶液注射在诸如癌症部位和眼内注射的血管化位点处。

    VARIABLE PRODUCT AGROCHEMICALS APPLICATION MANAGEMENT
    97.
    发明申请
    VARIABLE PRODUCT AGROCHEMICALS APPLICATION MANAGEMENT 审中-公开
    变量产品农化应用管理

    公开(公告)号：WO2012044833A2

    公开(公告)日：2012-04-05

    申请号：PCT/US2011054031

    申请日：2011-09-29

    Applicant: UNIV MISSOURI

    Inventor： MOTAVALLI PETER P ,  NELSON KELLY A

    IPC: G06F17/00

    CPC classification number: G05D21/02 ,  G06Q10/0631 ,  G06Q50/02

    Abstract: Methods and products are provided for facilitating application of variable- product agrochemicals, such as fertilizer, to an application area, such as a field. The fertilizer or agrochemical may include a single fertilizer or agrochemical type or a mixture. In one embodiment, a fertilizer-application area is divided into application cells, and a fertilizer product is determined for each cell, based on zones of the application area with a similar characteristic, such as topographic wetness index levels. Based on a determined product for each cell, instructions for controlling an agrochemical applicator are automatically generated.

    Abstract translation: 提供方法和产品以便于将诸如肥料的可变产品农用化学品应用到诸如田地的应用领域。 肥料或农用化学品可以包括单一肥料或农用化学品类型或混合物。 在一个实施例中，将肥料施用区域分成施用细胞，并且基于应用区域具有类似特征（诸如地形湿度指数水平）的区域为每个细胞确定肥料产品。 基于每个细胞的确定产品，自动生成用于控制农用化学品施用器的说明书。

    THIN DISK LASER OPERATION WITH UNIQUE THERMAL MANAGEMENT
    98.
    发明申请
    THIN DISK LASER OPERATION WITH UNIQUE THERMAL MANAGEMENT 审中-公开
    薄磁盘激光器具有独特的热管理功能

    公开(公告)号：WO2011091381A3

    公开(公告)日：2012-01-05

    申请号：PCT/US2011022289

    申请日：2011-01-24

    Applicant: INTEGRAL LASER SOLUTIONS LLC ,  UNIV MISSOURI ,  SCHLIE LAVERNE ARTHUR ,  MA HONGBIN ,  SMITH DOUGLAS E ,  GRUZDEV VITALY

    Inventor： SCHLIE LAVERNE ARTHUR ,  MA HONGBIN ,  SMITH DOUGLAS E ,  GRUZDEV VITALY

    IPC: H01S3/04 ,  H01S5/024

    CPC classification number: H01S3/042 ,  H01S3/0604

    Abstract: A thermal management apparatus and method for a thin disk laser system enabling the laser system to have near isothermal temperatures across and throughout a thin disk comprising a mechanically controlled oscillating heat pipe having effective thermal conductivity of 10 - 20,000 W/m*K that promotes near isothermal conditions in lasing of the thin disk, a thin disk lasing crystal or ceramic bonded to the mechanically controlled oscillating heat pipe, and a supporting structure including a surface bonded to the thin disk that matches the CTE (coefficient of thermal expansion) of both materials.

    Abstract translation: 一种用于薄盘激光系统的热管理装置和方法，其使得激光系统能够在整个薄盘上具有接近等温的温度，包括机械控制的振荡热管，其热导率为10-20000W / m * K，其促进近 薄板激光的等温条件，结合到机械控制的振荡热管的薄盘激光晶体或陶瓷，以及支撑结构，其包括与两个材料的CTE（热膨胀系数）匹配的薄盘的表面 。

    HIGH ENERGY-DENSITY RADIOISOTOPE MICRO POWER SOURCES
    99.
    发明申请
    HIGH ENERGY-DENSITY RADIOISOTOPE MICRO POWER SOURCES 审中-公开
    高能量放射性微波功率源

    公开(公告)号：WO2010105163A3

    公开(公告)日：2011-01-13

    申请号：PCT/US2010027148

    申请日：2010-03-12

    Applicant: UNIV MISSOURI ,  KWON JAE WAN ,  WACHARASINDHU TONGTAWEE ,  ROBERTSON JOHN DAVID

    Inventor： KWON JAE WAN ,  WACHARASINDHU TONGTAWEE ,  ROBERTSON JOHN DAVID

    IPC: G21H1/06

    CPC classification number: G21H1/00 ,  G21H1/06

    Abstract: A method of constructing a solid-state energy-density micro radioisotope power source device (10). In such embodiments, the method comprises depositing the pre-voltaic semiconductor composition (38A), comprising a semiconductor material and a radioisotope material, into a micro chamber (28) formed within a power source device body (14). The method additionally includes heating the body (14) to a temperature at which the pre-voltaic semiconductor composition (38A) will liquefy within the micro chamber (28) to provide a liquid state composite mixture (38B). Furthermore, the method includes cooling the body (14) and liquid state composite mixture (38B) such that liquid state composite mixture (38B) solidifies to provide a solid-state composite voltaic semiconductor (38), thereby providing the solid-state high energy-density micro radioisotope power source device (10).

    Abstract translation: 一种构造固态能量密度微放射性同位素电源装置（10）的方法。 在这样的实施例中，该方法包括将包含半导体材料和放射性同位素材料的预伏安半导体组合物（38A）沉积到形成在电源装置主体（14）内的微室（28）中。 该方法另外包括将主体（14）加热到预蒸发半导体组合物（38A）将在微室（28）内液化的温度以提供液态复合混合物（38B）。 此外，该方法包括冷却主体（14）和液态复合混合物（38B），使得液态复合混合物（38B）固化以提供固态复合伏安半导体（38），由此提供固态高能 密度微放射性同位素电源装置（10）。

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